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QSAR Models towards Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease

QSAR Models towards Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease

C. Gopi Mohan, Shikhar Gupta
Copyright: © 2017 |Pages: 46
ISBN13: 9781522505495|ISBN10: 1522505490|EISBN13: 9781522506386
DOI: 10.4018/978-1-5225-0549-5.ch022
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MLA

Mohan, C. Gopi, and Shikhar Gupta. "QSAR Models towards Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease." Oncology: Breakthroughs in Research and Practice, edited by Information Resources Management Association, IGI Global, 2017, pp. 591-636. https://doi.org/10.4018/978-1-5225-0549-5.ch022

APA

Mohan, C. G. & Gupta, S. (2017). QSAR Models towards Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease. In I. Management Association (Ed.), Oncology: Breakthroughs in Research and Practice (pp. 591-636). IGI Global. https://doi.org/10.4018/978-1-5225-0549-5.ch022

Chicago

Mohan, C. Gopi, and Shikhar Gupta. "QSAR Models towards Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease." In Oncology: Breakthroughs in Research and Practice, edited by Information Resources Management Association, 591-636. Hershey, PA: IGI Global, 2017. https://doi.org/10.4018/978-1-5225-0549-5.ch022

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Abstract

Alzheimer's Disease (AD) is a multifactorial neurological syndrome with the combination of aging, genetic, and environmental factors triggering the pathological decline. Interestingly, the importance of the Acetylcholinesterase (AChE) enzyme has increased due to its involvement in the ß-amyloid peptide fibril formation during AD pathogenesis. In silico technique, QSAR has proven its usefulness in pharmaceutical research for the design/optimization of new chemical entities. Further, QSAR method advanced the scope of rational drug design and the search for the mechanism of drug action. It is a well-established fact that the chemical and pharmaceutical effects of a compound are closely related to its physico-chemical properties, which can be calculated by various methods from the compound structure. This chapter focuses on different Quantitative Structure-Activity Relationship (QSAR) studies carried out for a variety of cholinesterase inhibitors for the treatment of AD. These predictive models will be potentially used for further designing better and safer drugs against AD.

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