日本耳鼻咽喉科学会会報
Online ISSN : 1883-0854
Print ISSN : 0030-6622
ISSN-L : 0030-6622
フロセマイドによると思われた難聴の症例
南 吉昇根本 聰彦
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ジャーナル フリー

1985 年 88 巻 9 号 p. 1193-1199

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The patient was a 76-year-old female. Because of heart disease she was administered on 40mg tablets of furosemide, a loop diuretic at the department of internal medicine. During taking furosemide, she noticed bilateral hearing loss, which developed into profound deafness. Therefore furosemide was withdrawn, and started treatment of steroid(Rinderon), MethycobalR and other drugs which were considered appropriate for acute sensorineural deafness. As a result, her hearing recovered. The authors described the course of deafness in this case and reviews in the literature. A search of the literature reveals no clinical case of furosemide-induced deafness in Japan, but in Western countries the following three characteristics of furosemide-induced deafness have been revealed. Briefly, (1) it is liable to occur after an intravenous bolus of 1, 000 to 2, 000mg; (2) hearing loss often occurs immediately or 10 to 20 min. after intravenous administration of the drug; and (3) the disturbance is generally transient, reversible sensorineural deafness that improves toward normal in 4 to 5 hours. Furthermore, the following three factors are considered to be related to the onset of furosemide ototoxicity; (1) dose per unit time, (2) severe renal function impairment, and (3) coadministration of furosemide and an aminoglycoside antibiotics. However, our patient was negative for renal function impairment and aminoglycoside antibiotics, and developed severe deafness after usual oral doses of furosemide. As compared to cases thus far described in the literature, our patient can be considered rather exceptional.

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