Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells134
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Key Words
folate deficiency
L-homocysteine
mRNA-binding protein
posttranscriptional RNA operon
αCP1
poly(C)-binding proteins
glutathione
iron chaperone
folate receptors
nutrition-sensitive
Abbreviations
CAT
chloramphenicol acetyltransferase
FAM
5′6-carboxyfluorescein
GST
glutathione S-transferase
HA
highest affinity
HF
high-folate
hnRNP-E1
heterogeneous nuclear ribonucleoprotein E1
HPV16
human papillomavirus type 16
iron(II)
ferrous sulfate heptahydrate
iron(III)
ferric chloride hexahydrate
JOE
6-carboxy-4′,5′-dichloro-2′,7′-dimethoxyfluorescein
KD
dissociation constant
LF
low-folate;
neurofilament M
neuronal intermediate neurofilament–middle molecular mass
siRNA
small interfering RNA
5′-UTR
5′-untranslated region
Cited by (0)
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HNJ is deceased.
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Supported in part by NIH grants CA120843 and HD39295, and a Veterans Affairs Merit Review Award (to ACA).
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This article reflects the views of one of the authors (DKH) and should not be construed to represent the FDA's views or policies.
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Supplemental Figures 1–5, Supplemental Table 1, Supplemental Methods, Supplemental Results, Supplemental Discussion, and Supplemental References are available from the ‘‘Online Supporting Material’’ link in the online posting of the article and from the same link in the online table of contents at http://jn. nutrition.org.
Copyright © 2017 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.