Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease—FLAVURS: a randomized controlled trial12345
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From the Hugh Sinclair Unit of Human Nutrition (ALM, TWG, MFC, DSA, YJ, AV, JPES, OBK, KMT, A-MM, MHG, and JAL), and the Institute for Cardiovascular and Metabolic Research, Department of Food and Nutritional Sciences (ALM and JAL), University of Reading, Reading, Berkshire, United Kingdom.
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ALM and TWG are joint first authors.
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Present address: for TWG, Northumbria University, Faculty of Health and Life Sciences, Newcastle upon Tyne, United Kingdom; for KMT, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all’Adige, Trento, Italy; for A-MM, Norwich Medical School, University of East Anglia, Norwich, United Kingdom; for MFC, Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Singapore.
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Supported by the Food Standards Agency, United Kingdom (project no. N02039/F5234012). Sainsbury’s PLC (supermarket retailer) provided the study foods.
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Address correspondence and requests for reprints to JA Lovegrove, Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, Berkshire RG6 6AP, United Kingdom. E-mail: [email protected].
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Abbreviations used: ABP, ambulatory blood pressure; AIx, augmentation index; AUC, area under the flux versus time curve; BP, blood pressure; CRP, C-reactive protein; CVD, cardiovascular disease; DBP, diastolic blood pressure; DVP, digital volume pulse; eNOS, endothelial nitric oxide synthase; FLAVURS, FLAvonoids and Vascular function at the University of Reading Study; F&V, fruit and vegetable; HF, high-flavonoid; LDI, laser Doppler imaging with iontophoresis; LF, low-flavonoid; NO, nitric oxide; PWA, pulse wave analysis; PWV, pulse wave velocity; SBP, systolic blood pressure; SNP, sodium nitroprusside; VCAM, vascular cell adhesion molecule.