Bile Acids Induce Glucagon-Like Peptide 2 Secretion with Limited Effects on Intestinal Adaptation in Early Weaned Pigs1,2,2
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Abbreviations
Actb
β-actin
ASBT
sodium-dependent bile acid transporter
BSE
β-sitoesterol
CD
cluster of differentiation
CDC
chenodeoxycholic acid
EW
early weaning/weaned
FXR
farnesoid X receptor
Gcg
proglucagon
GLP
glucagon-like peptide
GLP-2R
glucagon-like peptide 2 receptor
GPCR
guanosine protein–coupled receptor
Il
interleukin
Lif
leukemia inhibitory factor
TGR5
guanosine protein–coupled bile acid receptor
Tbp
TATA-box binding protein
Tnf
tumor necrosis factor
TPN
total parenteral nutrition
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Supported by research grant IDI-20111330 from Centro para el Desarrollo Tecnológico Industrial (CDTI), Ministerio de Economĺa y Competitividad, España.
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Author disclosures: I. R. Ipharraguerre, G. Tedó, D. Menoyo, N. de Diego Cabero, J. J. Holst, M. Nofrarías, A. Mereu, and D. G. Burrin, no conflicts of interest.
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Supplemental Table 1, Supplemental Table 2, Supplemental Table 3 and Supplemental Figure 1, Supplemental Figure 2 are available from the “Online Supporting Material” link in the online posting of the article and from the same link in the online table of contents at http://jn.nutrition.org.
Copyright © 2013 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.