Eicosapentaenoic Acid Prevents and Reverses Insulin Resistance in High-Fat Diet-Induced Obese Mice via Modulation of Adipose Tissue Inflammation, ,
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Abbreviations used:
AA
arachidonic acid
AUC
area under the glucose curve
BSA
bovine serum albumin
DHA
docosahexaenoic acid
EPA
eicosapentaenoic acid
HF
high saturated fat
HF-EPA-P
high saturated fat eicosapentaenoic acid prevention
HF-EPA-R
high saturated fat eicosapentaenoic acid reversal
HOMA-IR
homeostasis model assessment of insulin resistance
IL-6
interleukin-6
LF
low fat
MCP-1
monocyte chemotactic protein-1
P
prevention
PAI-1
plasminogen activator inhibitor-1
R
reversal
TG
triglyceride
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Supported by USDA, National Institute of Food & Agriculture-National Research Initiative award 2005-35200-15224, an AHA predoctoral fellowship, University of Tennessee Obesity Research Center and AgResearch.
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Author disclosures: N. S. Kalupahana, K. Claycombe, S. J. Newman, T. Stewart, N. Siriwardhana, N. Matthan, A. H. Lichtenstein, and N. Moustaid-Moussa, no conflicts of interest.
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Supplemental Figure 1 is available with the online posting of this paper at jn.nutrition.org.
Copyright © 2010 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.