Analysis of dengue transmission using fractional order scheme

: In this paper, we will check the existence and stability of the dengue internal transmission model with fraction order derivative as well as analyze it qualitatively. The solution has been determined using Atangana-Baleanu in Caputo sense (ABC) with the help of Sumudu transform (ST). Atangana-Toufik (AT) and fractal fractional operator are used to analyze the dengue transmission which is an advanced approach for such types of biological models. Existence theory and uniqueness for the equilibrium solution are provided via nonlinear functional analysis and fixed point theory. Global stability of the system was also proved by using the Lyapunov function. Such kind of study helps us to analyze dengue transmission which shows the actual effect of dengue transmission in society, also will be helpful in future analysis and control


Introduction
Dengue is a multifaceted disease with affects human health badly. The dengue fever symptoms start to appear in 2 to 7 days [1][2][3]. It is during this period that differentiating dengue from other febrile diseases proves troublesome [4]. Most people do not give attention to this disease and do self-medication which does not effective for this disease. Secondary dengue infection increases the risk of disease harshness [5,6]. Unfortunately at a time, there is no specific vaccine exists for dengue treatment [7][8][9]. Dengue fever is similar to flu which can affect all age groups [10], the fever spread due to a mosquito named Aedes. When an infected mosquito bites a normal person the virus is entered into the body of a human through the skin. Hence, the most severe clinical presentation during the infection course does not correlate with a high viral load [11]. According to WHO, dengue-infected people can be divided into two groups uncomplicated and severe [12]. The people who suffer severe conditions are associated with organ impairment or harsh plasma escape and the left are considered uncomplicated [13].
The generalization of classical calculus is called fractional calculus which is concerned with the operation of integration and differentiation of fractional order. In the 19th century by using fractional calculus mathematicians introduce fractional differential equations, fractional dynamics, and fractional geometry. Fractional calculus is used in almost every field of science. It is used to model physical as well as engineering processes. The standard mathematical model of integer order does not work properly. Due to this reason, fractional calculus made a major contribution to the field of mechanics, chemistry, biology, and image processing. By using fractional calculus several physical problems are solved. By using integer-order derivatives the system shows many problems such as history and nonlocal effect. Primarily, all the studies were depending on Caputo fractional-order and Reimann-Liouville fractional derivatives (RLFD). Now a day it had been highlighted that these derivatives have an issue and the issue is they have a singular kernel. That is the reason so many new definitions were presented in the studies [18][19][20]. These new definitions were very impactful because they have nonsingular kernels which are according to their needs. Caputo fractional derivatives [21], the Caputo-Fabrizio derivative, and AB [22] fractional derivative e have differed from each other only because Caputo is defined by a power law, Fabrizio is defined by using exponential decay law, and ABC is defined by Mittage-Leffler (ML) law. Tateishi et al. describe the role of fractional time operator derivative in a study of anomalous diffusion [23]. We extended the nutrient-phytoplankton-zooplankton model involving variable-order fractional differential operators in [24]. To analyze the dynamics of the fractional calcium oscillation model, powerful techniques are applied to the governing non-linear fractional studied in [25] and some other applications of real-world problems are also studied in [26][27][28]. In [27] authors used Caputo derivative which kernel is singular and nonlocal properties. But we used ABC operator which is non-singular and nonlocal kernels.
This paper is organized as follows: In sections 1 and 2 consists of an introduction and basic definitions for analysis. Section 3 is for the stability and uniqueness of the proposed scheme with fixed pint theory. Gloabal stablitity was also proved with Lyapunov function. A numerical algorithm for results is developed with the AT scheme and Fractal fractional operator by using the Mittag Leffler function in sections 4 and 5. Conclusions of results are described in section 6.

Mathematical model
To develop the equation the dengue viruses are virulent and no other microorganism that about the human body. Initially, macrophages, monocytes, and other cells of the reticuloendothelial organ are a major source of dengue. The susceptible cell is denoted by , the infected cell by , and the free virus by is shown in Figure 1. By transforming the model in [29], with ABC is as follows: In the given model, we will suppose that all the parameters are taken as positive. By using the greenest supposition that α shows the growth of susceptible cells and at the rate ( ) they expire. Free virus particles infect susceptible cells at a rate corresponding to the product of their plenitudes ( ) ( ). The viability of the process is shown by . Septic cells yield free virus at a rate proportional to their plenitude ( ), with n being the multiplication rate, and free infection particles are expelled from the system at a rate ( 1 + 2 ) ( ), where 1 is the natural demise rate of the virus and 2 is the death rate of the virus by T-cells. The free virus also moves to the susceptible cells compartment as ( ) ( ) and infected cells bite the dust at a rate ( ).

Equilibrium points of model
The equilibrium point of (5) is attained by cracking the non-linear algebraic equations System (5) has a disease-free equilibrium point 0 ( / , 0,0) if 0 < 1, while if 0 > 1, there is in addition to 0 , a positive endemic equilibrium * ( * , * , * ) and the values of * , * and * are as follows: where 0 is the basic reproduction number defined in [29] as follows: .
The value that 0 takes can signpost the situations where an epidemic is conceivable. Threshold quantity ( 0 ) is used to analyze the stability of the system (5) and the values of the following parameters given in Table 1. Applying ST on the proposed model given in (5) we get Rearranging, we get Now using the inverse ST on Eq (8), we have We next obtain the following recursive formula.
And the solution of (9) is provided by Therefore, applying the derivative respect to t on both sides yields Now, we can write their values for derivatives as follows Putting = − * , = − * , = − * leads to We can organize the above as follows To avoid the complexity, the above can be written as It is concluded that if Σ < Ω, this yields, < 0, however when, = * , = * , = * 0 = Σ − Ω ⇒ = 0.
We can see that the largest compact invariant set for the suggested model in is the point { * } the endemic equilibrium of the considered model. By the help of the Lasalles invariance concept, it follows that * is globally asymptotically stable in Γ if Σ < Ω. Theorem 3.2. Let ( , |. |) be a Banach space and a self-map of satisfying Proof. Define K be a self-map [30] is given by Applying the properties of the norm and triangular inequality, we get Hence K is Picard K-stable. Theorem 3.3. The special solution of Eq (5) using the iteration method is the unique singular solution.
Where (  This completes the proof of uniqueness.

Advanced numerical scheme (AT method)
Applying the advanced numerical scheme AT method on system given in Eq (5) and fundamental theorem of fractional calculus, we get At a given point τ +1 , = 0,1,2,3, …, the above equation is reformulated as By using equation above equations, we have Thus integrating equation (21) and Eq (22), and replacing them in equations of the system (23) we get

Dengue model fractal-fractional
We have the following model with fractal fraction operator in ABC sense is given as 0, 0, with initial conditions (6).

Numerical procedure with fractal fractional
We present the numerical algorithm for the fractal-fractional Dengue model (5). The following is obtained by integrating the system (5).
Using Eq (29) into the above system, we have Writing further above system, we have Now, calculating the integrals in above system, we get Inserting them into a system (31), we get  Finally, we have the following approximation:

Results and discussion
To identify the potential effectiveness of the dengue transmission in the Community, the dengue fractional-order model is presented to analyze its effect in society. That's why; we have used ABC with ST, advanced AT scheme, and fractal fractional derivative techniques for fractional-order dengue model. The various numerical methods identify the mechanical features of the fractional-order model with the time-fractional parameters. The results of the nonlinear system memory were also detected with the help of fractional values.

Conclusions
In this manuscript, we have investigated a non-integer order dengue internal transmission model with the help of the Picard successive approximation technique and Banach contraction theorem. The arbitrary derivative of fractional order and has been taken ABC with MLK. The concerned results have been handled by coupling ST with mentioned iterative techniques. Also, an algorithm was developed with AT and fractal fractional techniques for numerical results. Existence theory and uniqueness for the equilibrium solution are provided via nonlinear functional analysis and fixed point theory. Global stability of the system was also proved by using the Lyapunov function. The arbitrary derivative of fractional order has been taken in the ABC and fractal fractional Atangana-Baleanu with Mittag-Leffler kernel. Non-linear fractional differential equations were raised from the derivative with the help of a non-singular and non-local kernel within the fractional derivative framework. This kind of study is helpful for a physician for planning and decision-making for the treatment of the disease.