Samiha M. Gawish¹, Amina A. Gamal El Din², Hanaa H. Ahmed³, Abdel Razik H. Farrag^2*, Amira Abou-El Kheir<sup>1

1</sup>Textile Division, National Research Centre, Cairo, Egypt; ²Pathololgy Department, National Research Centre, Cairo, Egypt; 3Hormones Department, National Research Centre, Cairo, Egypt
 

AIM: The present work aimed to investigate the effect of the antimicrobial nano Ag/polypropylene (PP\Ag) dressing on incisional wound healing on the experimental level.

MATERIALS AND METHODS: Male albino rats were divided into, control, PP/Ag dressing, Silver Sulfadiazine (Ag-SD) cream, blank PP dressing and undressed groups. Animals were sacrificed after 5, 10 and 15 days of incisional wound event.

RESULTS: Reduction was found in incision wound length in PP/Ag dressed rats, Ag-SD cream treated rats, and blank PP dressed rats after 5, 10 and 15 days compared to undressed rats. Skin of PP/Ag group showed less adverse histopathological changes, enhanced granulation tissue formation, enhanced angiogenesis, accelerated re-epithelialization and quick complete healing; compared to all other groups. Significant decrease in TGF-β level was recorded in PP\Ag and Ag-SD cream groups as compared to blank PP group on day 5. While, significant decrease in TGF-β level was detected in PP\Ag group when compared with undressed and blank PP groups on day 10. TGF-β showed significant in PP\Ag group as compared to undressed, Ag-SD cream and blank PP groups on day 15.

CONCLUSION: The present results suggest that PP/Ag dressing enhances, promotes and plays an important role in wound healing.
 

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Citation: Gawish SM, El Din AAG, Ahmed HH, Farrag ARH, Abou-El Kheir A. Effect of Newly Synthesized Polypropylene/Silver Nonwoven Fabric Dressing on Incisional Wound Healing in Rats. Maced J Med Sci. 2014 Sep 15; 7(3):395-403. http://dx.doi.org/10.3889/MJMS.1857-5773.2014.0407.
Key words: Polypropylene/Silver; Nonwoven; Dressing; Wound healing; Rats.
*Correspondence: Prof. Abdel Razik H. Farrag. National Research Centre, Pathology, 33 Elbohooth St. Dokki Cairo, Egypt 12622, Egypt. E-Mail: abdelrazikfarrag@yahoo.co.uk
Received: 03-Mar-2014; Revised: 11-May-2014; Accepted: 12-May-2014; Online first: 18-Jun-2014
Copyright: © 2014 Gawish et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing Interests: The authors have declared that no competing interests exist.

 

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