Abstract
Two new indirubin-3′-oxime derivatives, indirubin-3′-[O-(3-bromoprop-1-yl)-oxime] (2) and indirubin-3′-[O-(methoxycarbonylmethyl)-oxime] (3) were synthesized. Their structures were confirmed by ESI-MS and NMR spectroscopic method. Both of them (5 μg/mL) significantly caused a elevation of cell growth, alkaline phosphate activity, and mineralization in osteoblastic MC3T3-E1 cells (p<0.05).
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Cuong, N.M., Tai, B.H., Hoan, D.H. et al. Synthesis and anti-osteoporosis potential of two new indirubin-3′-oxime derivatives. J. Korean Soc. Appl. Biol. Chem. 53, 22–26 (2010). https://doi.org/10.3839/jksabc.2010.004
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DOI: https://doi.org/10.3839/jksabc.2010.004