Harnessing the versatility of hydrazones through electrosynthetic oxidative transformations

Hydrazones are important structural motifs in organic synthesis, providing a useful molecular platform for the construction of valuable compounds. Electrooxidative transformations of hydrazones constitute an attractive opportunity to take advantage of the versatility of these reagents. By directly harnessing the electrical current to perform the oxidative process, a large panel of organic molecules can be accessed from readily available hydrazones under mild, safe and oxidant-free reaction conditions. This review presents a comprehensive overview of oxidative electrosynthetic transformations of hydrazones. It includes the construction of azacycles, the C(sp2)−H functionalization of aldehyde-derived hydrazones and the access to diazo compounds as either synthetic intermediates or products. A special attention is paid to the reaction mechanism with the aim to encourage further development in this field.


Introduction
Hydrazones represent an important class of organic compounds.They can be readily prepared through the condensation of hydrazine derivatives with aldehydes or ketones.They have found widespread applications in materials sciences and supramolecular chemistry [1][2][3][4][5].Importantly, they are versatile reagents in organic synthesis.They have for instance been frequently employed for the construction of azacycles through various cyclization protocols or cycloaddition reactions [6][7][8][9][10].Early work in this field includes the well-known Fischer indole synthesis [11].Additionally, they have been harnessed as valu-able intermediates in Wolff-Kishner reduction reactions [12][13][14] or for the synthesis of various olefins via diazo or vinyllithium intermediates in the Bamford-Stevens reaction [15] and Shapiro reaction [16], respectively [17].SAMP/RAMP ((S)/(R)-1amino-2-methoxymethylpyrrolidine)hydrazones could be also key intermediates for the asymmetric synthesis of α-substituted aldehydes and ketones [18,19].Interestingly, depending on the substitution pattern, the C=N bond can feature different electronic properties [20].For instance, various hydrazones have been employed for the asymmetric preparation of chiral amines through the addition of nucleophilic partners [21,22] while the azaenamine character of some aldehyde-derived hydrazones has been demonstrated in the coupling with suitable electrophiles such as Michael acceptors [23,24].Last but not least, the C=N bond of hydrazones can act as radical acceptors for the synthesis of functionalized amines or hydrazones through reductive functionalization [21,25,26] or oxidative C(sp 2 )-H functionalization [27,28], respectively.Consequently, given their rich reactivity profile, exploring new synthetic transformations of hydrazones is of significant importance and can contribute to the formation of novel organic compounds.
Electrosynthesis enables the generation of either radical, radical ionic or ionic species [29] under mild and environmentally friendly reaction conditions [30,31].The direct use of electrical current to drive oxidative and reductive processes precludes the reliance on toxic or dangerous redox reagents [32].The explosive renewal of interest in this technology and the resulting recent achievements have brought it at the forefront of organic synthesis.Electrooxidative transformations of hydrazones offer appealing opportunities to take advantage of the versatility of this reagent.Such an approach can either ameliorate the previous methods in a more sustainable and efficient fashion or provide a mean for the discovery of new reactivity.Herein, this review aims to give an overview of the state of the art in the electrochemical oxidative transformations of hydrazones.It is organized in four main parts: (i) synthesis of azacycles, (ii) synthesis of functionalized hydrazones through C(sp 2 )-H functionalization of aldehyde-derived hydrazones, (iii) access to diazo compounds, and (iv) synthesis of miscellaneous compounds.For reactions carried out under constant current electrolysis, the reported current applied (in A or mA) is depicted.Additionally, when possible, and for better accuracy, the current density (in mA•cm −2 ) has been calculated based on the size of the electrode portion immersed in the solution, as described in the experimental section.This information is provided in brackets.

Review Synthesis of azacycles
Nitrogen-containing heterocyclic compounds possess numerous applications in various domains such as materials science, agrochemistry and medicinal chemistry.Especially, 60% of all FDA-approved drugs in the United States contain at least one azacycle [33].Therefore, the development of gentle and efficient methods for accessing these heterocycles is an ongoing pursuit for synthetic chemists.As mentioned above, with their two nitrogen atoms, hydrazones constitute unique synthons for constructing azacycles.Resorting to electrochemical approaches furnishes original compounds.Although the first report dates back to 1974, this tool has only been seriously considered in the last 15 years.
In 1976, the same group reported the anodic cyclization of chalcone-derived N-phenylhydrazone 3 to pyrazole 4 in a divided cell at constant current (Scheme 2) [37].The obtained poor yield was explained by the formation of dimeric side products.Cyclic voltammetry analysis suggested an initial anodic single electron transfer (SET) to radical cation 5, cyclization and deprotonation.Subsequent SET oxidation in solution by 5 led to cation 7. Final deprotonation furnished aromatic cycle 4.
In 2022, Zhang et al. documented the synthesis of 1H-indazoles 9 via the electrooxidative cyclization of (hetero)aromatic ketones-derived N-phenylhydrazones 8 (Scheme 3) [38].In contrast with the above-mentioned works, the electrolysis was carried out in an undivided cell under galvanostatic conditions.High yields were obtained regardless of the electronic properties of the substituents on the N-phenyl ring.When dissymmetric diaryl ketone-derived substrates were employed, the C-N bond formation occurred selectively on the most electron rich aromatic ring.According to the proposed mechanism, this dehydrogenative cyclization of hydrazones initiated with the SET anodic oxidation of the hydrazone and deprotonation to form the N-centered radical 10.After aza-cyclization on the aromatic ring, a second SET oxidation and deprotonation delivered the heterocycle 9.This mechanism was supported by cyclic voltammetry analysis of a model substrate (1-(diphenylmethylene)-2-(4-nitrophenyl)hydrazine), which displayed three oxidation peaks (0.9, 1.7 and 2.2 V vs Ag + /Ag in HFIP ).The authors assumed that the two first peaks would correspond to the oxidation of 8 to 10 and 11 to 12 and that the oxidation of 10 would be responsible for the final one, which is consistent with the finding of ketone side-product.
In 2018, the group of Zhang established an intramolecular C(sp 2 )-H functionalization of aldehyde-derived N-(2pyridinyl)hydrazones 15 to produce 1,2,4-triazolo [4,3a]pyridines 16 (Scheme 4) [39].Interestingly, the hydrazone was in situ prepared prior to the electrolysis through the condensation of 2-hydrazinopyridine 13 and various aromatic, aliphatic and α,β-unsaturated aldehydes 14.The electrooxidative transformation was performed under constant current at 7 mA in a mixture of acetonitrile and water under heating.From a mechanistic point of view, the authors proposed the formation of N-pyridyl radical 18 through the anodic oxidation of in situgenerated anion 17.Subsequent radical cyclization, second anodic cyclization and deprotonation yielded the fused heterocycle 16.
porting electrolyte in a divided cell equipped with carbon rod anodes and a platinium coil cathode, the transformation would involve cyclization of carbocationic species 25 to form the intermediate 26.From 23a (R 2 = H), the latter would undergo deprotonation delivering the oxadiazole 24a.Alternatively, from 23b (R 2 ≠ H), nucleophilic addition of methanol to oxycarbenium 26b yielded the oxadiazoline 24b (Scheme 6) [41,42].
In 2020, Lei, Zhang and Gao et al. described the electrooxidative cyclization of in situ-generated α-keto acid-derived NH-acylhydrazones to build 1,3,4-oxadiazole derivatives in good yields.The electrolysis was conducted under galvanostatic conditions in methanol using a carbon graphite anode and a platinum cathode.From a mechanistic point of view, in situ condensation of acylhydrazines 28 with α-keto acids 27 produced hydrazones 29.After deprotonation, the authors proposed that the carboxylate anion underwent SET anodic oxidation/decarboxylation/radical cyclization sequence to form radical intermediates 34.Subsequent second anodic oxidation and deprotonation yielded the desired heteroaromatic 5-membered rings 30.Importantly, a control experiment using benzaldehyde-derived N-benzoylhydrazone delivered the corresponding 1,3,4-oxadiazole in only 25% yield.This result indicates that benzaldehyde-derived hydrazone is a less probable reaction intermediate, thereby supporting the proposed mechanism (Scheme 7) [43].
In parallel, Sheng and Zhang et al. found that 2-(1,3,4-oxadiazol-2-yl)aniline derivatives 38 could be electrochemically synthesized from isatins 35 and acylhydrazine 36.The transformation was carried out in an undivided cell at high temperature in DMSO using potassium iodide as supporting electrolyte with potassium carbonate as a base and two platinum electrodes.
Mechanistically, condensation of the two reactants formed isatin-derived acylhydrazone 37. Hydrolysis of the latter in the presence of the inorganic base gave rise to potassium carboxylate 39.Meanwhile, two consecutive SET oxidations of the iodide anion generated molecular iodine which reacted with 39 to furnish unstable hypoiodous anhydride 40, thereby triggering the key CO 2 extrusion.The resulting C(sp 2 )-centered radical 42 underwent a SET anodic oxidation/cyclization/deprotonation sequence to yield the oxadiazole derivative 38.As such, the iodide electrolyte served as an electromediator to both promote the decarboxylation process and protect the aniline product from overoxidation.Importantly, a control experiment without electricity but in the presence of molecular iodine instead proceeded smoothly, thereby confirming the critical role of in situ-generated molecular iodine (Scheme 8) [44].

Formal cycloaddition
Hydrazones constitute a versatile building block for the construction of azacycles through formal cycloaddition reactions.Under oxidative electrochemical conditions, either the oxidation of the hydrazone or the partner might be investigated offering numerous possibilities for the assembly of heterocycles.
As early as 1988, Tabaković and Gunić examined the anodic oxidation of aldehyde-derived NH-arylhydrazones 44 in the presence of pyridine and (iso)quinolone derivatives 45 in acetonitrile-tetraethylammonium perchlorate solution under constant potential in a divided cell equipped with platinum gauze anode and nickel cathode.Such a transformation constituted a straightforward route to the corresponding fused s-triazolo perchlorates 46 in moderate to high yield.Coulometric analysis established that the electrolysis was a four-electron oxidative process.Based on this study, the authors proposed the initial anodic oxidation of hydrazone 44 through the loss of two electrons and one proton to form cation 47.Subsequent nucleophilic addition of the azaarene led to new highly acidic cationic species 48.The latter underwent deprotonation and cyclization to form fused system 49.Final two-electron oxidation and deprotonation delivered the ionic product 46 (Scheme 9) [45].
For the construction of non-ionic azacycle from aldehydederived NH-arylhydrazones, the electrolysis is generally conducted in the presence of iodide anion as electromediator.An important challenge is to avoid the competitive formation of the corresponding methoxy(phenylazo)alkane [46,47] or carbonyl compound [48] upon SET anodic oxidation of the hydrazone and subsequent reaction with methanol or water, respectively.In 2018, Yuan and Yang developed a multicomponent synthesis of 1-aryl and 1,5-disubstitued 1,2,4-triazoles using tetrabutylammonium iodide as electromeditor [49].1-Methylene-2- arylhydrazine 52 was in situ generated through the condensation of paraformaldehyde 51 with arylhydrazines 50, while the electrolyte ammonium acetate and the alcoholic solvent acted as N and C1 sources, respectively.The authors proposed the mechanism depicted in Scheme 10.The deprotonation of hydrazone 52 afforded anion 54 which underwent SET anodic oxidation to form radical 55.In parallel, an elusive oxidation of alcohol electromediated by iodine would furnish aldehyde 56.Electrogenerated iodine would further assist the reaction with ammonia to form N-iodo aldimine intermediate 57.Subsequent radical cycloaddition between 56 and 57 would furnish cyclic hydrazinyl radical 58.Finally, the triazole would be obtained Scheme 9: Synthesis of fused s-triazolo perchlorates [45].
after hydrogen atom abstraction by iodide radical and deprotonation.
conventional methods for the generation of the nitrile imine involved the use of unstable hydrazonoyl halides or the oxidation of aldehyde-derived hydrazones under harsh reaction conditions.In 2023, the group of Waldvogel presented a formal electrooxidative (3 + 2)-cycloaddition between aldehydederived hydrazones 72 and alkenes 73 to yield a large range of N-arylpyrazolines 74 under mild reaction conditions (Scheme 14) [58].A biphasic system (aqueous/organic) was engineered during which the oxidation of the iodide mediator took place in the aqueous place, thereby protecting sensitive dipolarophiles such as styrenes from side reactions (e.g., overoxidation or polymerisation) in the organic phase.Ethyl acetate was employed as organic solvent for ethyl glyoxylate phenylhydrazone 72a while methyl tert-butyl ether was preferred for aromatic and aliphatic aldehyde-derived hydrazones 72b.Styrenes, enamines as well as electron poor aliphatic alkenes were all suitable dipolarophiles.From a mechanistic point of view, the authors proposed the electrogeneration of iodine in the aqueous phase.Under high stirring, the latter would react with NH-arylhydrazones 72 in the organic phase to furnish the N-iodo hydrazonium 75 and ultimately the nitrile imine 76 under basic conditions provided by the cathodic process.The critical role of the in situ cathodic generation of the base was supported by a control experiment in a divided cell, where no conversion was achieved.Given its abundance, stability, and low price, elemental sufur (S 8 ) is an ideal source of sulfur atom to produce thiacycles [62].
using ammonium iodide as electrocatalyst.Interestingly, no additional electrolyte was required.The transformation accommodated various substituents on the aromatic moiety regardless of their electronic properties.However, 4,5-disubstituted 1,2,3thiadiazoles could not be accessed with this methodology.Mechanistically, control experiments with radical trapping agent such as TEMPO ((2,2,6,6-tetramethylpiperidin-1-yl)oxyl) or 1,1-diphenylethylene proceeded with similar efficiency, thereby excluding any radical pathway.As such, it was proposed that the catalytic electrooxidation of iodide (E NH4I = 0.41 V and 0.75 V vs Ag/AgCl in dimethylacetamide for I − /I 3− and I 3− /I 2 redox couples) into iodine provided a green and mild tool to in situ generate the α-iodo ketone-derived NH-tosylhydrazone 92 and ultimately the azadiene 93 upon elimination of HI.In agreement with a previous report [63], further formal (4 + 1) cycloaddition with S 8 followed by elimination of S 7 and sulfinic acid gave rise to the aromatic cycle 91 (Scheme 17) [64].
The direct C(sp 2 )-H functionalization of aldehyde-derived N,Ndialkylhydrazones has been also explored for constructing
cient tool for accessing various hydrazones under mild reaction conditions and, to some extent, broadening the scope of more conventional radical approaches.Typically, two mechanistic pathways can be proposed depending on the oxidation potentials of each partner.If the hydrazone is the most readily species to be oxidized, initial SET anodic oxidation of the hydrazone furnishes the highly electrophilic radical cation species D, which undergo nucleophilic addition of the second partner and deprotonation to produce hydrazinyl radical F (route a).Alternatively, if the partner possesses a lower oxidation potential than the hydrazone, then the transformation initiates with the anodic generation of radical species Y • , that adds to the hydrazone leading ultimately to hydrazinyl radical F as well (route b).In both cases, a second SET anodic oxidation and deprotonation yields the functionalized hydrazone (Scheme 20).

Initial SET oxidation of the hydrazone
In 1973, Barbey and Caullet have shown that the benzaldehydederived N,N-diphenylhydrazone 107 dimerized upon electrochemical oxidation on platinum electrode [68].The following year, they demonstrated that in the presence of an excess of pyridine, triphenylphosphine or tetraethylammonium cyanide, the corresponding pyridium 109, phosphonium 111 and cyano hydrazones 113 were obtained, respectively (Scheme 21) [69].
In 2020, Ruan and Sun et al. communicated the electrochemical dehydrogenative coupling between (hetero)aromatic or aliphatic aldehyde-derived hydrazones 114 and diarylphosphine oxide 115.The phosphorylation proceeded with slightly higher yield in the presence of a catalytic amount of manganese dibromide but its role was not clearly identified.Cyclic voltammetry analysis supported the initial oxidation of the hydrazone (E p/2 of 4-methylbenzaldehyde-derived hydrazone = 0.89 V vs Ag/AgCl in CH 3 CN and E p/2 of diphenylphosphine oxide > 0.89 V vs Ag/AgCl in CH 3 CN) (Scheme 22) [70].Similar yields were previously obtained for the same transformation using a substoichiometric amount of potassium persulfate as oxidant [71].
In 2022, the group of Huang employed aromatic azoles 118 as additional suitable nucleophilic partners for C(sp 2 )-H functionalization of aldehyde-derived N,N-disubstituted hydrazones 117.A wide range of aldehyde-derived hydrazones reacted smoothly with various azoles including pyrazole derivatives, imidazole, pyrazole and triazoles (Scheme 23) [72].Cyclic voltammetry studies confirmed that the azoles were redox inactive in the scan window while benzaldehyde-derived morpholino hydrazone could be readily oxidized at 1.18 V vs SCE in CH 3 CN supporting the route (a) of the general mechanism in Scheme 20.

Initial SET oxidation of the partner
As mentioned above, if the partner is more readily oxidized than the hydrazone, then the general mechanism of the process Scheme 22: Phosphorylation of aldehyde-derived hydrazones [70].
is as described in Scheme 20, following route (b) for the first anodic oxidation.While investigating the electrochemical oxidative C(sp 2 )-H thiocyanation of ketene dithioacetals, Wang and Yang et al. mentioned one example of thiocyanation of benzaldehyde-derived hydrazone 120 using potassium thiocyanate as a source of thiocyanate radical.The electrolysis was conducted in the presence of two equivalents of water in acetonitrile with lithium perchlorate as electrolyte.It is interesting to notice that the isomerization of the product and subsequent ring closure discussed above (see Scheme 17) did not occur under these conditions (Scheme 24) [73].
electrodes.Aromatic and aliphatic sodium sulfinates 124 were employed as sources of sulfinate radicals under electrolyte-free reaction conditions.The targeted product was obtained in high yield regardless of the electronic properties of the substituents on the aromatic ring of either the hydrazone or the sulfinate salt (Scheme 25) [74].In parallel, a similar transformation was developed by Guo and Yang et al.Using two platinum electrodes and n-Bu 4 NBF 4 as supporting electrolyte in a 1:1 mixture of acetonitrile/water, heteroromatic aldehyde-derived hydrazones as well as heteroaromatic sodium sulfinate salts were additional compatible reagents [75].
In 2022, Xie et al. achieved the electrochemical C(sp 2 )-H trifluoromethylation of (hetero)aromatic aldehyde-derived hydrazones.The galvanostatic electrolysis was performed with two carbone graphite electrodes.The Togni reagent 127 was chosen as a source of trifluoromethyl radical with redox neutral and electron-rich hydrazones through a paired electrolysis.In contrast, the Langlois reagent 128 was preferred for electronpoor substrates through an electrooxidative process (Scheme 26) [76].

Electrochemical access to diazo compounds
Diazo compounds are highly useful synthetic reagents in organic chemistry.For instance, they are regularly utilized as 1,3-dipoles in cycloaddition reactions or as precursor of carbenes under thermal, photochemical, and catalytic transitionmetal-based transformations.However, their use is significantly hampered by their inherent instability and hazardous nature.Therefore, it is endlessly highly demanding to find a new mode of generation of diazo compounds from stable and safe precursors.The third part of this review is dedicated to electrochemical synthesis of diazo compounds from hydrazones.Transformations involving diazo compounds as either products or intermediates are covered.
While investigating the electrochemical oxidation of benzophenone hydrazones 130, Chiba et al. discovered that several products were obtained depending on the reaction conditions.For instance, the use of lithium perchlorate as supporting electrolyte in acetonitrile at room temperature in a divided cell equipped with two platinum electrodes led exclusively to diazines 131 in good yields.In contrast, when the electrolysis was conducted in methanol containing sodium methoxide in an undivided cell, three main products (namely benzophenone dimethyl acetals 133, diphenylmethyl methyl ethers 134 and diphenylmethanes 135) were obtained, the ratio of which was influenced by the electrode materials, the temperature and the amount of sodium methoxide.The range of isolated yields of the major products obtained under the appropriate reaction conditions is shown in Scheme 27.Based on control experiments, the authors proposed that 133-135 came from diazo intermediates 132, which could not be isolated [77].
Building on this study and considering the high ability of diazo compounds to react with alkenes, Chiba et al. developed the electrochemical construction of diphenylcyclopropanes 137 from benzophenone hydrazones 130 and methacrylic acid derivatives 136.The transformation was conducted on a large scale (60 mmol) in an undivided cell using graphite anode and platinum cathode materials at 55 °C with a minimal amount of sodium methoxide, thereby limiting side products formation such as 133-135 or some oligomers of ethylenes (Scheme 28) [77].
In 2002, Okimoto et al. reported the indirect electrochemical oxidation of benzilhydrazones 138 using potassium iodide as electromediator for synthesising α-diazoketones 139 in good yields.The electrolysis was performed at low temperature in a divided cell equipped with a platinum anode and a nickel cathode.It was not possible to isolate the diazo compounds arising from the electrooxidation of 4,4'-dimethylbenzilhydra-zone and 4,4'-dimethoxybenzilhydrazone (X = H, Cl).In these cases, the diazo compounds directly underwent both Wolff rearrangement and overoxidations to yield a mixture of the corresponding diphenyl acetal and benzil dimethyl acetal (akin to the conversion of 132 into 133 in Scheme 27), respectively (Scheme 29) [78].Using a similar procedure, the same authors subsequently reported the electrochemical oxidation of dibenzoylbenzene dihydrazones into the corresponding bisdiazo compounds [79].
In 2022, Ollevier and Lam et al. undertook an in-depth study for accessing stabilized diazo compounds through anodic oxidation of simple unsubstituted hydrazones 140.After intensive parameter optimizations, good yields were achieved under galvanostatic conditions in a simple divided cell equipped with cheap carbon graphite anode and nickel cathode using potassium iodide and ammonium acetate as electrolyte.Cyclic voltammetry analysis suggested that potassium iodide would serve as an electromediator to oxidize the hydrazone through an innersphere electron transfer.Moreover, the electrolysis proceeded more efficiently in the presence of ammonium acetate since (i) the acetate anion would serve as a base to facilitate the oxidation of the hydrazone and (ii) the ammonium cation would provide a performant proton source to counterbalance the overall process, thereby protecting the diazo product from cathodic reduction (akin to the conversion of 132 into 135 in Scheme 27).Based on these studies, the authors proposed the initial anodic formation of the iodonium species [(CH 3 CN) 2 I + ], which would react with the hydrazone to furnish the protonated diazo compound 143 via the N-iodo hydrazone intermediate 142.Further acetate anion-assisted deprotonation ultimately led to the desired diazo compounds 141 (Scheme 30) [80].A nice application of this procedure involved the (3 + 2)-cycloaddition reaction between electrogenerated diphenyldiazomethane and methyl acrylate delivering the corresponding pyrazoline in good yield (68%).
Olefins are highly common structural motifs in natural and synthetic organic compounds.They are also often employed as pivotal element during the total synthesis of natural products.Therefore, the development of mild and efficient methods to undergo SET reduction from an electron donor to furnish the olefin product 148.In the cathodic chamber, reduction of the acidic proton of TFA counterbalance the overall transformation.A wide range of carbonyl compounds including aromatic and aliphatic aldehydes and ketones as well as various alkene partners were compatible.Of note, the most thermodynamically stable distonic radical was formed, thereby allowing the formation of only one isomer of the olefin product (Scheme 31) [81].

Miscellaneous
In 1990, Chiba and Okimoto established an electrosynthetic procedure to convert the carbonyl group of aliphatic ketones 153 into a cyanomethylene group.Condensation of 153 with methyl carbazate (154) furnished the corresponding methoxycarbonylhydrazone 155.The latter was charged in the anolyte compartment of a divided cell containing sodium cyanide and acetic acid in methanol and was allowed to stand for several days in the dark in the absence of an electrical current, thus allowing the addition of in situ-generated HCN to the hydrazone 155.After addition of a second equivalent of sodium cyanide, the resulting HCN adduct 156 was electrolyzed under constant current to form diazene 157, which subsequently underwent addition of methanol/fragmentation and extrusion of nitrogen to yield the nitrile derivative 159.The transformation proceeded neither with aldehydes nor with aromatic ketones (Scheme 32) [82].
In 2008, Okimoto et al. reported the electrochemical oxidation of ketone-derived NH-allylhydrazones 160 into the corresponding azines 161.The electrolysis was conducted in a divided cell equipped with a nickel coil cathode and a platinum anode under constant current in methanol.Both potassium iodide and sodium methoxide were required as electrolyte supports to achieve high efficiency.The former would assist the oxidation of the hydrazone through the in situ generation of iodonium as oxidant while the latter would facilitate the deprotonation of iodoammonium 162 and the elimination of HI from N-iodo intermediate 163.The best yields were obtained with aromatic ketonederived hydrazones (Scheme 33) [83].

Conclusion
Given the rich reactivity profile of hydrazones, the electrooxidative transformations of such a molecular building block provides a fascinating route to valuable compounds under mild and safe reaction conditions.Alone, the electrooxidation of NH-aryl, -tosyl, and -acylhydrazones triggered the cyclization of a radical cation intermediate enabling the construction of pyrazole, triazole and oxadiazole derivatives, while the electrooxidation of unprotected NH 2 hydrazones constitutes a useful mean to access to relevant diazo compounds as products or synthetic intermediates.When coupled with a second reactant, electrooxidative processes gave rise to various azacycles or to functionalized hydrazones through C(sp 2 )−H functionalization of aldehyde-derived hydrazones.In both cases, transformations involving either the initial oxidation of the hydrazone or the partner have been demonstrated by carefully adapting the reaction conditions to selectively oxidize the desired compound.In some cases, the use of an electromediatior such as an iodide anion helped in achieving the desired selectivity.In line with the continuing increasing interest for both electrosynthetic Scheme 33: Electrochemical oxidation of ketone-derived NH-allylhydrazone [83].
organic transformations and the chemistry of hydrazones, coupling with other partners or examination of different hydrazones, such trifluoromethylated hydrazones, should enable the straightforward access to diversely functionalized molecules.Hopefully, this review will stimulate further development in this area which could eventually find useful applications in industry.

Funding
The CNRS and ICSN are gratefully acknowledged for financial support.

Final formal ( 3 + 2 )-cycloaddition with the dipolarophiles 73 delivered the pyrazolines 74 .
It is interesting to note that a complementary(3 + 2)-cycloaddition between aldehyde hydrazones and alkenes for the preparation of pyrazolines was proposed by Tong, Song, et al., achieving similar efficiency using oxone/KBr as an environmentally friendly oxidative system[59].Most recently, Zhou and Ma et al. described the electrochemical access to 3-aminopyrazoles 79 from arylpropynal-derived NH-arylhydrazones 77 and secondary amines 78 in moderate to good yields.Potassium iodide was employed as electrolyte and mediator in ethanol in an undivided cell equipped with a carbon graphite and a platinium cathode.The transformation initiated with the electrochemical generation of iodonium through a two-electron process.Subsequent reaction with the hydrazone and deprotonation formed the N-iodo hydrazone intermediate 80, triggering the reaction with the amine 78 through cationic species 81.Final cyclization delivered the desired pyrazole 79 (Scheme 15)[60].The group of D. Tang engaged aromatic aldehyde-derived NH-tosylhydrazones 83 in an iodide-catalyzed electrochemical formal (3 + 2)-cycloaddition with quinolines 84 to build[1,2,4]triazolo[4,3-a]quinoline derivatives 85.Better yields were obtained with hydrazones bearing an electron-rich substituent on the aromatic ring.The reaction initiated with anodic formation of iodine.The latter would react with hydrazone 83 to form the zwitterionic species 86 under basic conditions.Subsequent formal (3 + 2)-cycloaddition with the quinoline 84 formed fused system 87 which underwent elimination of iodide and sulfinic acid to furnish the aromatic product 85, thereby regenerating the catalyst (Scheme 16)[61].