Abstract
Naloxone hydrochloride, in doses of.5 to 10 mg/kg intraperitoneally, reduced water consumption by rats fluid deprived for 24 h. Administered intracerebroventricularly, 100 micrograms of naloxone produced similar effects while doses of 50 micrograms or less had no effect. Naloxone (10 mg/kg) also reduced consumption of a palatable solution (10% sucrose, weight/volume) by nondeprived rats. Morphine sulfate (.5 to 2 mg/kg) failed to increase consumption.
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This work was supported by Grant DA02044 from the National Institute on Drug Abuse. Naloxone hydrochloride was provided courtesy of Endo Laboratories.
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Stapleton, J.M., Ostrowski, N.L., Merriman, V.J. et al. Naloxone reduces fluid consumption in water-deprived and nondeprived rats. Bull. Psychon. Soc. 13, 237–239 (1979). https://doi.org/10.3758/BF03335069
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DOI: https://doi.org/10.3758/BF03335069