Abstract
Damage to medial frontal cortex impaired the performance of rats during DRL 20 acquisition. This deficit was diminished when a feedback stimulus signaled the termination of the required delay. CRF response rates were not affected by frontal damage. It is noted that previous investigations have demonstrated DRL deficits following frontal damage in cat and monkey, but not in rat when frontal-polar cortex is removed. Our results, therefore, support the view that medial frontal cortex, rather than frontal-polar cortex, is the rat homologue to frontal association cortex of more advanced species. The relationship between fronto-limbic connections and response regulation is discussed.
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The research reported in this paper was supported by Grant MH-14182-06 from the United States Public Health Service. We wish to thank Renee Culver and Everett Magagnos for their technical assistance, and Kathleen McGovem and Jean Mackey for help in preparing the manuscript.
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Numan, R., Seifert, A.R. & Lubar, J.F. Effects of medio-cortical frontal lesions on DRL performance in the rat. Psychobiology 3, 390–394 (1975). https://doi.org/10.3758/BF03326847
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DOI: https://doi.org/10.3758/BF03326847