Inappropriate use of BI-RADS Category 3 : Learning from mistakes

© www.appliedradiology.com January-February 2019 Breast imaging subspecialists and general radiologists who interpret breast images should adhere to the unique lexicon of the American College of Radiology Breast Imaging Reporting and Data System Atlas (ACR BI-RADS®). The atlas was designed to ensure that breast findings are appropriately analyzed and correctly designated to one of seven BI-RADS categories, each of which implies a specific management recommendation. BI-RADS 3 was created to help reduce the number of false-positive biopsies, while maintaining a high rate of early cancer detection. Five major studies from 1987 to 2001 helped establish that BI-RADS 3 lesions have ≤2% chance of malignancy.1-5 Understanding when it is appropriate to place a finding into the BI-RADS 3 category is essential for radiologists interpreting diagnostic mammograms and ultrasounds. A BIRADS 3 category should only be given after a complete diagnostic work-up, which may include additional mammographic views and often sonographic evaluation. BI-RADS 3 is strongly discouraged as a final assessment from a screening mammogram. Finally, BIRADS 3 is not to be used as a category of uncertainty and should not be used as a safety net to place findings that a radiologist is unsure whether to pass as benign or biopsy.


B
reast imaging subspecialists and general radiologists who interpret breast images should adhere to the unique lexicon of the American College of Radiology Breast Imaging Reporting and Data System Atlas (ACR BI-RADS ® ).The atlas was designed to ensure that breast findings are appropriately analyzed and correctly designated to one of seven BI-RADS categories, each of which implies a specific management recommendation.BI-RADS 3 was created to help reduce the number of false-positive biopsies, while maintaining a high rate of early cancer detection.
2][3][4][5] Understanding when it is appropriate to place a finding into the BI-RADS 3 category is essential for radiologists interpreting diagnostic mammograms and ultrasounds.A BI-RADS 3 category should only be given after a complete diagnostic work-up, which may include additional mammographic views and often sonographic evaluation.BI-RADS 3 is strongly discouraged as a final assessment from a screening mammogram.Finally, BI-RADS 3 is not to be used as a category of uncertainty and should not be used as a safety net to place findings that a radiologist is unsure whether to pass as benign or biopsy.

What is BI-RADS 3?
BI-RADS 3 is a category reserved for specific mammographic findings which have a 0% to ≤ 2% likelihood of malignancy based on robust evidence. 6ccording to the fifth edition of the ACR BI-RADS ® Atlas, there are three mammographic findings (when seen on a baseline mammogram or mam-mogram without comparisons) which meet criteria for a BI-RADS 3 assessment and they include: [6][7][8][9] • noncalcified solid mass with round or oval morphology and at least 75% circumscribed margins; • solitary group of round microcalcifications, and, • focal asymmetry without associated calcifications or architectural distortion.Guidelines also exist for specific, probably-benign sonographic findings, but are less well established in the literature.Supporting evidence ranges from prospective controlled trials to expert opinion.There are six sonographic findings which meet criteria for BI-RADS 3 and they are:  • refraction shadowing without presence of an associated mass; and, • architectural distortion thought to be due to postsurgical scar.The management recommendation after a diagnostic mammogram and/or ultrasound is rendered a final BI-RADS 3 assessment is short-term follow-up.Short-term surveillance should include the modality(ies) which best demonstrated the finding.Surveillance protocols vary across institutions, but are commonly performed at 6, 12, and 24 months, with some extending out to 36 months. 6The finding should be followed until at least two years of stability is documented, with the longest acceptable surveillance protocol being three years. 6nderstanding what can be appropriately placed into BI-RADS category 3 on initial evaluation and objectively reassessing findings at follow-up are essential.At subsequent follow-up, radiologists should be meticulous in reassessing the finding for suspicious characteristics or changes to avoid dangerous pitfalls in diagnostic interpretation.Findings placed in the BI-RADS 3 category are not expected to change in a suspicious manner.They should not grow, develop noncircumscribed margins or suspicious calcifications, or become denser.If the finding is assessed as suspicious at follow-up, it is the responsibility of the interpreting radiologist evaluating the patient at follow-up to acknowledge the change and upgrade the BI-RADS to category 4 or 5 with a recommendation for biopsy. 6

Solitary group of round microcalcifications
A screening mammogram performed on an asymptomatic 60-year-old woman demonstrated grouped round and amorphous calcifications in the upper outer quadrant of the left breast.An associated focal asymmetry was noted to be stable for several years.The screening exam was assessed BI-RADS 0, with recommendation for additional evaluation with magnification views.Magnification views (Figure 1A) demonstrated grouped round and amorphous calcifications, with a final assessment of BI-RADS 3, probably benign and short-term follow-up in 6 months recommended.The 6-month follow-up diagnostic mammogram (Figure 1B) showed unchanged, but persistent, grouped round and amorphous calcifications, and the diagnosis was upgraded to BI-RADS 4A, low suspicion for malignancy, with biopsy recommended.Stereotactic biopsy was performed and pathology returned ductal carcinoma in situ.
In this case, amorphous and new round calcifications were present.A solitary group of round calcifications can be assessed BI-RADS 3 after complete diagnostic evaluation when initially seen on a baseline mammogram or without prior exams for comparison, 6 but new round calcifications and amorphous calcifications do not meet these criteria.The presence of new calcifications initially should have prompted biopsy.Furthermore, assessment of microcalcifications should be based on the most worrisome morphology or distribution, and it is the most suspicious finding which should prompt action. 6he positive predictive value (PPV) of malignancy for amorphous calcifications is approximately 20%, based on review of multiple single-institution consecutive-case series, 6 and this exceeds the maximum 2% chance of malignancy that defines the BI-RADS 3 category.Although round calcifications on a baseline may meet criteria for category 3 assessment, the presence of new round or amorphous calcifications merit a BI-RADS 4 assessment with recom-  This case exemplifies the importance of calcification morphology and ascribing the appropriate BI-RADS assessment.A problematic, well-known reality in breast imaging is interobserver variability when describing microcalcifications. 10 To account for this, it is essential for the interpreting radiologist to re-evaluate all follow-up studies, as well as the initial study, to ensure appropriate BI-RADS assessment.The radiologist who interpreted the 6-month follow-up exam in this case correctly acted on the finding of amorphous microcalcifications with recommendation for biopsy.

One-view asymmetry with comparison
A screening mammogram on an asymptomatic 80-year-old woman demonstrated a new one view asymmetry in the lateral right breast (Figure 2A).The screening exam was assessed BI-RADS 0, with additional evaluation requested.At diagnostic follow-up, a magnified CC view was performed in which the asymmetry, although low density, did not efface.Sonographic evaluation of the entire lateral right breast was normal.The final assessment from the diagnostic work-up was BI-RADS 3, probably benign, with short-term follow-up in 6 months recommended.The follow-up diagnostic mammogram (Figure 2B) showed the one-view asymmetry had increased in density.On repeat ultrasound (Figure 2C), an irregular indistinct and microlobulated mass was identified, and the BI-RADS score was upgraded to 4B, with biopsy recommended.Ultrasound-guided core biopsy pathology returned invasive mucinous carcinoma.
This case illustrates the difficulty in evaluating one-view asymmetries and the importance of attention to change at follow-up.Any new or enlarging asymmetry that cannot be attributed to summation artifact should be considered suspicious, with biopsy recommended instead of follow-up. 11Although Sickles has established that over 80% of one-view asymmetries are related to summation artifact, those determined to be real through recall with additional projections have similar imaging and clinical outcomes as other findings recalled for additional assessment. 8[14]

One-view asymmetry without comparison
A 66-year-old asymptomatic woman presented for baseline screening mammography, which demonstrated a one-view asymmetry in the medial right breast (Figure 3A).The exam was assessed a BI-RADS 0 for additional evaluation.The diagnostic spot magnification view showed the asymmetry persisted, but ultrasound evaluation was negative.The diagnostic study was assessed a BI-RADS 0, with recommendation for further evaluation with MRI.The patient's insurance company denied the MRI, so an addendum was made to change the BI-RADS assessment to 3, with recommendation for short-term followup.The 6-month follow-up diagnostic exam (Figure 3B) demonstrated the medial asymmetry had enlarged and was now identified on two views.Sonographic evaluation at follow-up demonstrated a 3-cm irregular, spiculated mass (Figure 3C).The BI-RADS assessment was upgraded to 5, highly suggestive of malignancy.The patient subsequently underwent ultrasound guided core biopsy, which revealed invasive lobular carcinoma.Any asymmetry seen on a baseline screening mammogram, or an exam without comparisons that is confirmed with diagnostic mammography and is without ultrasound correlate, can be considered for short-term follow-up, stereotactic biopsy, or surgical excision. 15These three options are quite different, and the final recommendation partly depends on the radiologist's level of suspicion and experience.
In this case, attention to suspicious changes at follow-up led to the correct assessment and a BI-RADS upgrade, with recommendation for biopsy.This case also illustrates why the BI-RADS ® Atlas specifically cautions against assigning diagnostic breast imaging exams a final BI-RADS assessment of 0 for the recommendation of additional imaging with breast MRI. 6A breast MRI may be recommended and can be helpful in evaluating difficult one-view findings. 16owever, the recommended MRI may never be performed due to insurance or financial restrictions, contraindications related to renal disease, or implanted foreign devices among other reasons.Furthermore, the MRI may not resolve or aid clarification of the finding.For these reasons, the interpreting radiologist should issue a final BI-RADS assessment to the diagnostic mammogram or ultrasound.

Architectural distortion
Architectural distortion without a correlative history of surgical scar is considered suspicious and should be biopsied. 6The only scenario in which it can be appropriate to follow architectural distortion is when it is most consistent with a postsurgical scar. 6Skin markers can help correlate with the site of scarring.Without the appropriate history for a scar, the differential diagnosis is limited to cancer or complex sclerosing lesions/radial scar, and tissue diagnosis is the most appropriate action. 6 screening mammogram performed on a 45-year-old asymptomatic woman  showed an area of architectural distortion in the right breast near 12 o'clock, for which BI-RADS assessment 0 was made for additional imaging.Spot magnification views (Figure 4A) showed persistent architectural distortion with no sonographic correlate, and the finding was assessed BI-RADS 3, probably benign, with short-term follow-up recommended.The follow-up diagnostic mammogram (Figure 4B) showed a persistent, but stable area of architectural distortion at 12 o'clock, again without a sonographic correlate.Final BI-RADS assessment of 4C, high suspicion for malignancy, was made with surgical excision recommended.Pathology returned a complex sclerosing lesion.
Although the architectural distortion was stable at short-term follow-up, the interpreting radiologist made the most correct decision to biopsy the finding as this patient had no history of breast surgery.6][17] Partyka et al showed that digital breast tomosynthesis makes subtle findings of architectural distortion more conspicuous and increases detection when used as an adjunct as part of the screening mammogram. 17This is especially advantageous due to the high PPV of malignancy reported for architectural distortion that is tomosynthesis-detected, but sonographically occult. 18Architectural distortion can only be considered for BI-RADS 3 short-term follow-up when there is history compatible with a surgical scar.

Palpable mass
Scrutinizing mass shape and margins is crucial in gauging suspicion of malignancy.Even a small mass seen with ultrasound should be considered suspicious if the margins are non-circumscribed.For a mass to be called "circumscribed" on ultrasound, all margins should be well defined or sharply defined. 6 39-year-old woman presented with a palpable area of concern in the left breast.There was no mammographic correlate, but a small mass on ultrasound (Figure 5A) correlated with the palpable area.This 7-mm correlative mass was characterized as oval and non-circumscribed, was assigned BI-RADS category 3, and short-term follow-up was recommended.Followup ultrasound (Figures 5B) showed a 2-cm irregular mass with microlobulated and angular margins.Additionally, a left axillary lymph node with eccentric cortical thickening was identified (Figure 5C).The final BI-RADS assessment was upgraded to 5, highly suggestive of malignancy, with biopsy recommended.Ultrasound-guided core biopsy of the mass was performed, with pathology returning invasive ductal carcinoma and metastatic involvement of the axillary lymph node.
As discussed previously, negative ultrasound findings should not deter recommendation for biopsy of a suspicious mammographic finding.Likewise, a negative mammogram should not deter biopsy recommendation of a suspicious ultrasound finding.In this case, the initial mammogram was noncontributory, but the mass was seen with ultrasound.Furthermore, the margins of mass were described as "non-circumscribed."Only solid masses that are circumscribed, oval, parallel to the skin, hypoechoic, and with minimal posterior enhancement or without posterior features, can be considered for follow-up in the probably benign category. 60][21][22][23] However, strict adherence to BI-RADS category 3 criteria is crucial to avoiding a delay in cancer diagnosis.

Conclusion
Many BI-RADS 3 lesions are diagnostically challenging cases.A BI-RADS 3 final assessment should not be given for a screening exam.Category 3 is reserved for cases only after a complete diagnostic imaging work-up has been performed and the finding has been shown to meet probably benign criteria.During breast imaging interpretation, it is paramount to remember that the BI-RADS 3 category is not an acrossthe-board catch-all in which to place nonspecific imaging findings.When faced with a difficult imaging scenario in which one may consider placing a finding into this follow-up category, reviewing BI-RADS 3 criteria can provide insight.Additionally, the ACR Appropriateness Criteria ® can offer direction to radiologists faced with a difficult case.As shown in these examples, zealous attention to detail is required at follow-up, as one should reconsider the appropriateness of the initial BI-RADS 3 assessment while concurrently searching for suspicious changes or new suspicious findings.

FIGURE 1 .
FIGURE 1. (A) Screening mammogram showed new grouped round and amorphous calcifications in the left upper outer quadrant, which were assessed a BI-RADS 0 for magnification views.Associated focal asymmetry at this location was stable for many years.Diagnostic magnification ML and exaggerated CC views pictured show the grouped round (open arrow) and amorphous (closed arrow) calcifications in the upper outer quadrant.Final assessment was BI-RADS 3, with short-term follow-up recommended.(B) Diagnostic magnification views of the left breast show persistent grouped round (open arrow) and amorphous (closed arrow)calcifications assessed BI-RADS 4A, low suspicion for malignancy.

FIGURE 2 (
FIGURE 2 (A) Screening mammogram showed a new one view asymmetry in the lateral right breast, which was assessed BI-RADS 0, needs additional imaging.The diagnostic mammogram, pictured, again shows the one view asymmetry in the lateral right breast (circle), without a sonographic correlate.Final assessment was BI-RADS 3, with recommendation for short-term follow-up.(B) Mammogram shows persistent asymmetry in the lateral right breast, but the asymmetry is increased in density (arrow).(C) Correlate on grayscale ultrasound demonstrates an irregular, indistinct, and microlobulated mass at 10:00, 5 cm from the nipple.Final BI-RADS assessment was changed to 4B, moderate suspicion for malignancy.

FIGURE 3 .
FIGURE 3. (A) Screening mammogram shows a one-view asymmetry in the medial right breast (circle), which was assessed BI-RADS 0, additional imaging recommended.Spot magnification MLO of the right breast showed the asymmetry persisted and there was no sonographic correlate.Final BI-RADS was assessed a 0, additional evaluation recommended with MRI.(B) Follow-up diagnostic mammogram of the right breast shows the asymmetry, now seen in two views (circle).(C) A 3-cm irregular, indistinct and spiculatedshadowing mass at 9:30, 1-2 cm from the nipple on grayscale ultrasound correlated to the mammographic finding.Final BI-RADS was assessed a 5, highly suggestive of malignancy, biopsy recommended.

FIGURE 4 .
FIGURE 4. (A) Screening mammogram demonstrated architectural distortion in the right breast, which was assessed BI-RADS 0. Pictured spot magnification views show persistent architectural distortion (arrows).There was no sonographic correlate.Final BI-RADS assessment was a 3, probably benign, short-term follow-up recommended.(B) Spot magnification views of the right breast show persistent architectural distortion at 12:00 with increased density (arrow) and no sonographic correlate.Final BI-RADS assessment was a 4C, high suspicion for malignancy.

FIGURE 5 .
FIGURE 5. (A) Grayscale sonogram shows a 7-mm microlobulated mass without mammographic correlate.At initial evaluation, the shape was called oval, but in retrospect and as seen on this static ultrasound image, the shape is irregular.Final BI-RADS assessment of 3, probably benign, with short-term follow-up recommended.(B) Follow-up diagnostic grayscale ultrasound image now demonstrates a 2-cm irregular mass with microlobulated and angular margins at the palpable area in the left breast.(C) Grayscale ultrasound shows a left axillary lymph node with eccentric cortical thickening.Final BI-RADS assessment of 5, highly suggestive of malignancy. 6