Primary mammary angiosarcoma in a male

CASE SUMMARY A 65-year-old male presented with a blue-tinted, palpable mass located lateral to the midline of his left chest. No trauma, rash, or pain was associated with the region. He denied personal or family history of breast cancer. However, the patient had a remote history of squamous cell carcinoma, which was surgically removed several inches from his site of palpable concern. He also underwent radical prostatectomy for prostate cancer. No radiation treatment was used for the described cancers. Imaging studies were obtained and subsequent biopsy revealed primary angiosarcoma.


IMAGING FINDINGS
Mammography of the left breast demonstrated a 1.5 × 0.8 cm uncalcified, oval mass at the 9-10 o'clock position, which corresponded to the site of palpable abnormality (Figure 1A).Ultrasound revealed a correlating 1.3 × 0.5 × 0.8 cm isoechoic mass that was subsequently biopsied (Figure 1B).Staging computed tomography (CT) with intravenous and oral contrast showed no evidence of metastatic disease.

DISCUSSION
Angiosarcoma of the breast is a rare malignancy of vascular endothelial cells that accounts for less than 1 percent of primary breast cancer in women, and is exceedingly uncommon in men. 1,2Mammary angiosarcomas are classified as either primary or secondary. 3,4Primary angiosarcoma generally afflict younger women (40-50 years of age) without predisposing risk factors.They typically present as a rapidly growing, painless, palpable mass that may demonstrate bluish skin discoloration.Secondary angiosarcoma usually develops in older patients with a history of breast cancer treated with local radiation therapy and/or chronic post-operative lymphedema, also known as Stewart-Treves syndrome. 3,5The prototypical appearance is a violaceous, red rash, which may delay correct diagnosis when mistaken for bruising or post-radiation skin changes. 3,4,5iagnosing angiosarcoma is challenging due to the rarity of these tumors as well as their nonspecific and variable presentation across different imaging modalities.Mammographic findings for primary angiosarcoma include an ill-defined, noncalcified mass or focal asymmetry. 2,4,5,6Secondary angiosarcoma may demonstrate skin thickening, which is difficult to discriminate from expected post-irradiation skin changes. 5onographically, primary angiosarcomas may appear hyperechoic, hypoechoic, or heterogeneous with well-circumscribed to ill-defined margins.Hypervascularity on Doppler and disruption of normal breast architecture are also common.Skin thickening may be the only detectable abnormality for secondary angiosarcoma on ultrasound.

Primary mammary angiosarcoma in a male
Lisa B. Awan, MD; Geetha Bhandarkar, MD; Jessica Kim, DO; and Tayson Lin Histological features of angiosarcoma depend on tumor grade. 7Grade I, low-grade, angiosarcomas are characterized by anastomosing vascular channels containing pleomorphic round to oval proliferating endothelial cells with hyperchromatic nuclei (Fig-ure 2).Grade II angiosarcoma contain more admixed endothelial elements projecting into the vascular lumen and increasing evidence of mitoses.Grade III, high-grade, angiosarcoma are more undifferentiated and demonstrate malignant spindle, polygonal endothelial cells, with more defined papillary projections.Vascular elements are less recognizable.Mitoses, necrosis, and hemorrhage are also typical.Lower grade angiosarcoma may be differentiated based on histologic characterization alone.However,

FIGURE 2. Histopathology of ultrasound-guided core needle biopsy. (A) This photomicrograph captures prominent freely anastomosing vascular channels characteristic of low-grade angiosarcoma. (B) Higher magnification image demonstrates vascular proliferation lined by pleomorphic round to oval cells with hyperchromatic nuclei. Low mitotic rate (2-3 per 10 high power fields) and hemorrhage was observed.
However, no necrosis was demonstrated.Taken together, these findings are consistent with grade I angiosarcoma.immunohistochemical stains, including epithelial markers (EMA, cytokeratins) and vascular markers (CD31, Factor VIII, CD34), are often necessary to distinguish a high-grade angiosarcoma between stromal sarcomas, metaplastic carcinomas, fibrosarcomas, and liposarcomas. 2,4,6urgical resection with mastectomy, or to negative margins, is the mainstay of treatment for both primary and secondary forms of angiosarcoma. 1,3here are no clearly defined adjuvant chemotherapy or radiation regimens for mammary angiosarcoma.However, studies have shown that doxorubicin or paclitaxel treatments demonstrate some benefit. 1,3Hyperfractioned radiation in conjunction with chemotherapy may prevent recurrence in cases of secondary high-grade lesions. 2,8Axillary dissection is typically not indicated as metastatic nodal involvement is rare.

FIGURE 1. Diagnostic spot compression mammography and ultrasound. (A) Spot compression mammography revealed a circumscribed, oval mass at the 9-10 o'clock position. (B) Ultrasound showed an well-defined, isoechoic mass without any associated calcifications or skin thickening. Investigations of the right breast showed no abnormal findings.
Prognosis may be dependent on tumor grade, but is poor overall for both primary and secondary angiosarcomas. 3,7Five-year, disease-free survival for low-grade tumors may be as high as 76 percent, but as low as 15 percent for high-grade tumors. 9Unfortunately, both local and distant recurrences within five or as late as 20 years are common for both primary and secondary angiosarcomas. 10Hematogenous metastasis frequently affects bones, lungs, skin, and liver, and may even spread to the contralateral breast. 9

CONCLUSION
Mammary angiosarcoma is a rare, aggressive neoplasm of vascular or endothelial origin.Most accounts of mammary angiosarcoma are in females.This case is unique as there are only a few other documented cases of primary angiosarcoma of the male breast in the literature.Diagnosis of angiosarcomas is difficult due to their nonspecific, variable presentation on clinical and imaging studies.Mammographic findings for primary angiosarcoma may include a solid, noncalcified mass, or focal asymmetry.On ultrasound, primary angiosarcoma may appear as a hypoechoic, hyperechoic, or heterogeneous mass.Secondary angiosarcoma may only present as skin thickening on mammogram and ultrasound.For a definitive diagnosis, tissue sampling and subsequent histological studies are required.Surgical excision is the mainstay of treatment for mammary angiosarcoma, but adjuvant chemotherapy and hyperfractioned radiation therapy may improve patient outcome particularly in high-grade cases.
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