Coronary Artery Anomalies on CT Angiography

and Introduction


Introduction
The prevalence of coronary artery anomalies is reported to be approximately 1% to 2% in the general population. [1,2]The clinical presentation isvariable and the abnormality may remain clinically occult or it can have life-threatening consequences, such as myocardial infarction, arrhythmia, or even sudden death.Even if the anomalies are asymptomatic, knowledge of their presence is important at cardiac surgery to avoid inadvertent damage to a vessel with an anomalous course.
Various imaging modalities are available for coronary artery assessment.Traditionally, catheter angiography has been used to evaluate the coronary arteries and their anomalies; however, it is an invasive technique, and the exact course of the coronaries can sometimes be difficult to determine precisely.This is because angiography provides a 2-dimensional depiction of coronary anatomy and relies on a limited number of imaging planes, in contrast to cardiac computed tomography (CCT), which is noninvasive and has multiplanar capability.
In addition, the acquired imaging data can be post-processed and viewed in any desired plane.Magnetic resonance imaging (MRI) is another noninvasive technique that can depict the course of proximal coronary arteries, but without ionizing radiation exposure or intravenous contrast.However, it is not as widely available as CT, and is limited in the evaluation of the distal coronary arteries, and can be technically challenging to perform.For these reasons, CCT has recently emerged as the test of choice for diagnosing coronary anomalies. [2,3]In this article, we review the spectrum of coronary artery anomalies, particularly hemodynamically significant anomalies, as revealed by multidetector CT.

Normal Coronary Anatomy
There are left and right principal coronary arteries. [4]The left coronary system comprises the left main artery, which bifurcates into the left anterior descending artery (LAD) and the left circumflex artery (LCX).The right coronary artery (RCA) arises from the right anterior sinus of Valsalva and coursing through the right atrioventricular groove.

Left Coronary Artery and its Branches
The left main artery normally arises from the posteriorly positioned left sinus of Valsalva and bifurcates into the LAD and LCX (Figure 1) after a variable length of 2 to 40 mm. [4]The LAD courses through the anterior interventricular groove and provides diagonal branches to the anterior left >ventricle and septal branches to the anterior interventricular septum.The LCX gives off obtuse marginal branches (OM), which supply the lateralwall of the left ventricle.Occasionally, the left main artery can trifurcate into the LAD, the LCX, and a third vessel between the LAD and LCX termed the ramus intermedius artery.The course and vascular territory of the ramus intermedius artery are similar to those of the diagonal and/or obtuse marginal arteries. [5]

Right Coronary Artery and its Branches
The RCA arises from the anteriorly positioned right sinus of Valsalva (Figure 2) and courses through the right AV groove.The conus artery is the first branch of RCA in 50% of cases, and it supplies the right ventricular infundibulum.In the remaining 50% of cases, the conus artery arises directly from the aorta separately from the RCA. [5]The sinoatrial (SA) nodal branch arises from the RCA in most patients (60%) and courses posteriorly.In the remaining patients it arises as a branch of the LCX.Other branches supply the right atrium and free wall of the right ventricle.The largest of these arises from the RCA at the acute margin of the heart and is termed the acute marginal branch.At the crux of the heart the RCA gives off the posterior descending artery, which supplies the posterior interventricular septum.The posterolateral branch (PLB) is a continuation of the RCA in the posterior atrioventricular groove and supplies the posterior and inferior wall of the left ventricle (Figure 2).

Dominance
Generally, the artery that gives off the posterior descending artery is considered to be the dominant coronary artery. [3]The RCA is dominant in most subjects (85%), while in 7% to 8% of cases the LCX gives rise to the posterior descending artery (PDA), a left dominant system.In the remaining patients, a codominant, or balanced circulation, system exists; examples include a small PDA originating from the RCA with posterolateral branches from the LCX artery, and PDAs from both the RCA and LCX. [1,5]tably, the coronary artery nomenclature is based on the intermediate and distal vascular territory of the artery; this is particularly important when vessels are anomalous.In these circumstances, the proximal course or coronary origin cannot be considered when defining or naming the respective coronary artery. [3,6]For example, a subepicardial artery that courses through the anterior interventricular groove and provides septal branches is termed the LAD, regardless of its origin from the aorta.Similarly, for an artery to be defined as the LCX, it should course through the left atrioventricular sulcus and provide at least one obtuse marginal (OM) branch.The RCA is defined as an artery that runs in the right atrioventricular sulcus and gives off the acute marginal branch. [6]nary Artery Anomalies (CAA) Deviations from normal coronary anatomy are termed as variants or coronary artery anomalies (CAA).It has been proposed that a normalvariant refers to an alternative pattern that is relatively infrequent compared to normal, but is seen in more than 1% of the population; in contrast to an anomaly that is seen in less than 1% of otherwise normal individuals. [4,6,7]In the following discussion the authors review a spectrum of coronary anomalies and variants (for purpose of discussion these have been collectively grouped under "anomalies").][7][8] In this review the CAAs are divided into 4 main groups: [3,5] anomalies of origin, course, termination,and intrinsic (Table 1).Multiple Ostia.Three or more ostia are considered normal variants.This is most commonly due to the conus branch arising directly from the aorta, which is seen in 50% of subjects (Figure 3).The other common cause of multiple ostia is an absent left main artery with separate ostia for the LAD and LCX (estimated to be seen in 0.5% to 8% of population). [5]gle Coronary Ostium.In this rare anomaly only one coronary artery arises from a single ostium (0.0024% to 0.044% of the population). [3] gives rise to the left main and RCA or courses directly to the LAD, LCX, and RCA. [8]One or more arteries can have an anomalous course.This abnormality can have an adverse clinical outcome, particularly if one of the arteries takes an interarterial course (also termed a "malignant"course.See discussion below).

Anomalous Location of Ostium in
Relation to the Appropriate Coronary Sinus.a. High ostium.This refers to a coronary ostium (either left or right) that is at least 1 cm above the sinotubular junction (instead of being at the aortic sinus) [4,7] (Figure 4).Rarely, the coronary artery can arise from the aortic arch, the brachiocephalic artery, the internal mammary,bronchial, or subclavian arteries, or even the descending aorta.These situations are usually well tolerated and asymptomatic, but they may cause difficulties in cannulation during coronary angiography and cardiac bypass surgery. [1,7]Commissural Ostium.When the ostium is located within 5 mm of the commissure between 2 sinuses, it is termed a commissural ostium.[4,7] 3. Anomalous Origin of the Coronary Artery from Opposite Sinus.In this anatomy, the coronary artery arises anomalously from the opposite sinus and then takes one of the 4 paths described below.The precise path taken by the artery is important clinically.An interarterial course (previously called a malignant course) carries a high risk of sudden cardiac death, while the other 3 courses are considered nonmalignant or relatively benign.
a. Interarterial.In this case, a coronary artery (such as the RCA, left main, LAD or LCX) arises from the opposite sinus and courses between the aortic root and pulmonary artery/right ventricular outflow tract (Figures 5 and 6).This anomaly has been linked with sudden cardiac death.Several pathologic processes have been implicated; they include a narrow slit-like orifice, an acute angle of the ostium witha tangential proximal course of the ectopic coronary artery, and an intramural course where the coronary artery exits the aortic lumen and courses into the aortic wall before emerging on the surface.A consequence of this anomaly is lateral arterial compression, which worsens in systole, and the artery appears ovoid in cross-section. [2,3,6]The flow can be further compromised during exercise due to aortic dilatation.b.Transseptal (subpulmonic).This refers to the left main or LAD taking a subpulmonic course.The artery traverses anteriorly and inferiorly through the interventricular septum and takes an intramyocardial course, giving off septal branches and finally emerging at its normal epicardial position.It is considered a relatively benign anomaly, though in some cases of sudden and unexpected cardiac death it has been found to be the only reported abnormality (Figure 7). [9]

Inverted Coronary Arteries.
In this rare anomaly, the LCA arises from the right aortic sinus, and the RCA arises from the left aortic sinus.The anomaly can become hemodynamically significant if the anomalous artery courses interarterially. [10]omalous origin of the coronary artery from noncoronary sinus.Either the RCA or the left main can arise from the noncoronary sinus.This is a rare anomaly and may have no clinical relevance (Figure 10). [3]However, there are reports of cases that can be symptomatic, particularly if the proximal part of the artery has an intramural course inside the aortic wall and is hypoplastic. [11]gure 10.Anomalous origin of the left main artery from noncoronary sinus (black arrow) as seen on axial-CT (A) and volume-rendered image (B).(R, L, N refer to right, left and noncoronary sinuses).

Anomalous Origin of the Coronary Artery from Pulmonary Artery (ALCAPA)
. This is one of the most serious anomalies, with a 90% mortality rate in the first year of life. [2,3] ost patients are symptomatic in infancy and early childhood.Either the RCA (Figure 11) or the LCA can arise from the pulmonary artery.ALCAPA appears more common (0.008% versus 0.002% for RCA).It is conceivable that this apparent difference may be due to the fact that ALCAPA carries a worse prognosis and is more likely to come to clinical attention.In rare instances the LCX or both the RCA and the LCA can take origin from the pulmonary artery.Coronary artery origin from the pulmonary artery can occur as an isolated finding, though an associated cardiac abnormality, such as ASD, VSD, tetralogy of Fallot, aortic coarctation, double outlet right ventricle, and patent ductus arteriosus, can be seen in 5% of cases. [2,12]In the most common form of this anomaly, the LCA arises from the pulmonary trunk, and the RCA arises normally from the aorta (Bland-White-Garland syndrome).Extensive intercoronary collaterals develop that are often dilated and tortuous.Symptoms usually occur due to coronary steal phenomenon caused by the flow of blood from the higher pressure coronary arterial system to the lower pressure pulmonary arteries.Surgical treatment is usually recommended for these anomalies.

Anomalies Involving the Angle of Origin.
Normally the coronary artery arises perpendicularly to the aortic wall.However, the angle between the aortic wall and the proximal coronary artery can be quite variable.In its most extreme form, the origin can be slit-like or tangential,limiting coronary arterial flow. [4]omalies of Course 1. Myocardial Bridge.In this anomaly, a portion of the coronary artery that is normally epicardial traverses through the myocardium.The myocardial tissue covering the artery is called a myocardial bridge, and the artery itself is called a tunneled segment. [13]The bridging can be superficial or deep and has been most commonly described in the mid LAD-80% (Figure 12). [2]The myocardial bridge is diagnosed on catheterangiography by observing systolic compression of the artery, or the so-called "milking effect."Angiography may be somewhat insensitive to superficial bridging that does not cause significant systolic compression.However, coronary CTA can demonstrate the coronary artery directly(not just the lumen) and its relationship to the adjacent myocardium.The length and depth of tunneled segment can be accurately determined by CT.Additional indirect signs (such as systolic compression) can also be seen using retrospectively-gated coronary CT through different phases of the cardiac cycle.This capability of CT may explain the higher prevalence of myocardial bridging reported on CT (26%) compared to conventional angiography (0.5% to 4.5%). [13]Though myocardial bridging can be seen as a normal variant, without being clinically overt in a large proportion of cases, it has been infrequently linked with ischemia, tachycardia-induced ischemia, conduction disturbances, myocardial infarctions, and even sudden cardiac death. [2,7,13,14]Additionally, the coronary segment proximal to the tunneled artery is vulnerable to atherosclerotic disease presumably due to low-wall shear stress, while the tunneled segment itself may be protected because of high-wall shear stress. [13]re 12.Myocardial bridging (black arrow) as seen on a curved planar reformatted image of the LAD (A).Note the decrease in caliber of the artery in systole (C) compared to diastole (B) on a cross-sectional orthogonal view of the LAD.

2.
Duplication.This anomaly refers to 2 LAD arteries: one short LAD, which terminates in the anterior interventricular groove without reaching the apex, and one long LAD, which originates from the LAD proper or anomalously from the RCA/opposite sinus, enters the distalanterior interventricular groove, and terminates at the apex.Care should be taken to avoid mistaking a long LAD for a parallel diagonal branch.The differentiation is relatively straightforward, since a diagonal artery does not enter the anterior interventricular groove (Figure 13). [3]Knowledge of this anomaly is important for planning surgical vascularization and to avoid mistaking a short LAD artery for a mid-LAD occlusion.

Anomalies of Termination
1. Coronary Arteriovenous Fistula.This is an abnormal communication between a coronary artery and a cardiac chamber, coronary sinus, superior vena cava, or pulmonary artery.The prevalence is reported to be 0.002%. [10]Various etiologies are known; they include traumatic, infectious, and iatrogenic causes.The involved fistulous artery is often dilated and tortuous.Drainage is important to recognize and determines the hemodynamic abnormality.The most common site of drainage is the right ventricle creating a left to right shunt.
There may be steal phenomenon with consequent myocardial ischemia.Drainage to a left-sided heart chamber causes a hemodynamic state similar to aortic regurgitation.
Clinical symptoms are based on the induced hemodynamic abnormality.If the patient is symptomatic, treatment options include closing the fistula, either by coil embolization or by ligation of the fistula with or without coronary artery bypass graft (Figure 14). [2,10,15]Coronary Arcade.This is defined as angiographically evident connections between the RCA and LCA in the absence of coronary stenosis.Though small connections between the RCA and LCA are normal, these are not normally large enough to be visible on angiography.These connections differ from collaterals by virtue of straight connections between the coronaries in the absence of significant coronary artery disease.Coronary arcades are mainly seen near the crux of the heart.[3,16,17] 3. Extracardiac connections.Coronary arteries may have connections to extracardiac arteries, such as the bronchial, internal mammary,pericardial, superior and inferior pherenic, intercostals, and esophageal branches of the aorta.[17] These connections become significant with the development of coronary artery disease.

Intrinsic Coronary Arterial Abnormalities
1. Coronary stenosis.Though coronary stenosis is mostly acquired, congenital coronary stenosis has been described [2] and can be ostial (due to a valve-like ridge of the aortic wall or fusion of the aortic leaflets and aortic wall) or peripheral.

Congenital Atresia of the Left Main Coronary Artery.
In this condition there is complete atresia of the left coronary ostium, so the entire coronary arterial supply to the heart is derived from the RCA and its branches.
The LAD and LCX are seen in their respective locations,but they receive blood from the RCA.This is an extremely rare condition and differs from a single RCA because some of the branches fill retrograde through the RCA. [2]The collateral circulation from the right to the left coronary system is usually not sufficient so almost all patients eventually develop myocardial ischemia.Surgical reconstruction of a 2-coronary system by coronary artery bypass graft is performed in these patients.

Coronary Artery Ectasia or
Aneurysm.This lesion is defined as a coronary artery with a diameter of more than 1.5 times the adjacent normal segment and can be either focal or diffuse.Coronary aneurysms may be congenital or acquired; in the acquired group, Kawasaki disease is the most common cause of aneurysms worldwide. [5]Congenital aneurysms are more commonly described in the RCA. [2]Possible complications include myocardial infarction from embolization of thrombus. [5,18]

Figure 1 .
Figure 1.Normal coronary anatomy.3-dimensional volume-rendered CT image shows the left coronary artery system comprising the left main (LM), left anterior descending artery (LAD), and left circumflex artery.Note the diagonal (curved arrow) and obtuse marginal (straight white arrow) branches of LAD and LCX respectively.

Figure 2 .
Figure 2. Right coronary artery (RCA) anatomy on 3-dimensional volume-rendered CT image.(A) Note the normal origin of RCA and its course in the right AV groove.(B) Note the posterior descending artery (PDA) and posterior lateral branch (PLB) in a right dominant coronary artery system.

Anomalies of origin 1 . 1 .
Number of ostia: Multiple (>2), single 2. Anomalous location of ostium in the appropriate coronary sinus 3. Origin from opposite coronary sinus 4. Origin from noncoronary sinus 5. Origin from pulmonary artery 6. Abnormalities of angle of origin Anomalies of course (normal origin) Number of Coronary Ostia.Normally there are 2 coronary ostia (one for the right main coronary artery and one for the left).

Figure 3 .
Figure 3. (A and B) Multiple coronary ostia.Note the separate origin of the conus artery from the aorta (curved black arrow) on 3-dimensional volume-rendered and multiplanar reformatted CT image.

Figure 4 .
Figure 4. 3-dimensional volume-rendered image of coronary tree shows a high origin of the right coronary artery (black curved arrow) above the sinotubular junction.

Figure 5 .
Figure 5. Axial contrast-enhanced CT image shows an interarterial 'malignant' left main coronary artery (arrow) coursing between aorta and right ventricle outflow tract.There is a single ostium in right sinus of Valsalva with common origin of the right coronary artery and left main coronary artery.

Figure 6 .
Figure 6.Single vessel (straight white arrow) originating from left sinus of Valsalva with interarterial 'malignant' course of RCA (curved black arrow).

Figure 7 .
Figure 7. Transseptal or subpulmonic course of the LAD (black arrow) arising from right coronary sinus as seen on multiplanar reformatted image (A) and volume rendered image (B).The RCA in the case was normal in its origin and course (white arrow) while the LCX (curved arrow) was anomalous.It arose from the right sinus of Valsalva and followed a retroaortic course.c.Retroaortic..= This is the most common coronary artery anomaly, seen in 0.9% of the population.The ectopic coronary artery (more commonly the LCX) runs posteriorly between the aortic root and the left atrium (Figure8).

Figure 8 .
Figure 8. Anomalous retroaortic course of the left circumflex artery (LCX) (black arrow) arising from right coronary artery in two separate subjects as seen on volume-rendered (A) and axial contrast-enhanced CT image (B).(LA: left atrium).
d. Prepulmonic.The ectopic coronary artery runs anterior to the pulmonary artery or right ventricular outflow tract (Figure9).

Figure 9 .
Figure 9. Axial contrast-enhanced CT image showing anomalous LAD and LCX arising from the right sinus of Valsalva.The LAD courses anterior to the right ventricular outflow tract (i.e.prepulmonic) while the LCX courses posterior to the aortic root (retroaortic).

Figure 11 .
Figure 11.Anomalous origin of the right coronary artery (black arrow) from pulmonary artery.Note the dilated tortuous coronary artery and multiple collaterals.

Figure 13 .
Figure 13.Duplication of LAD seen on volume-rendered image of the heart (A) and coronary tree image (B).Note a short LAD (black arrow), which terminates high in the anterior interventricular groove without reaching the apex and a long LAD (white arrow) which courses parallel to the short LAD, enters the distal anterior interventricular groove and supplies the apex.

Figure 14 .
Figure 14.Right coronary artery to right ventricle fistula (arrow) as seen on volume-rendered images (A, B) and an oblique reformatted image (C).Note the dilatation and tortuosity of the fistulous vessel.