Techniques for Formulation of Nanoemulsion Drug Delivery System: A Review

Manish Kumar; Ram Singh Bishnoi; Ajay Kumar Shukla; Chandra Prakash Jain

doi:10.3746/pnf.2019.24.3.225

주제분류

...

저널정보

한국식품영양과학회
Preventive Nutrition and Food Science 학술저널
Preventive Nutrition and Food Science Vol.24 No.3
2019.9 225 - 234 (10page)
DOI : 10.3746/pnf.2019.24.3.225

저자정보

Manish Kumar (Mohanlal Sukhadia University)
Ram Singh Bishnoi (Mohanlal Sukhadia University)
Ajay Kumar Shukla (Mohanlal Sukhadia University)
Chandra Prakash Jain (Mohanlal Sukhadia University)

이용수
내서재: 0

내서재에 추가
되었습니다. 내서재에서
삭제되었습니다.

초록·키워드

오류제보하기

Nanoemulsion drug delivery systems are advanced modes for delivering and improving the bioavailability of hydrophobic drugs and the drug which have high first pass metabolism. The nanoemulsion can be prepared by both high energy and low energy methods. High energy method includes high-pressure homogenization, microfluidization, and ultrasonication whereas low energy methods include the phase inversion emulsification method and the self-nanoemulsification method. Low energy methods should be preferred over high energy methods as these methods require less energy, so are more efficient and do not require any sophisticated instruments. However high energy methods are more favorable for food grade emulsion as they require lower quantities of surfactant than low energy methods. Techniques for formulation of nanoemulsion drug delivery system are overlapping in nature, especially in the case of low energy methods. In this review, we have classified different methods for formulation of nanoemulsion systems based on energy requirements, nature of phase inversion, and self-emulsification.

#nanoemulsion #drug delivery #high energy method #low energy method #phase inversion methods