Prevalence , morbidity and mortality of hypertriglyceridemic acute pancreatitis in the General Hospital of Playa del Carmen , México . Analysis of five years

Introduction: Hypertriglyceridemia (HTG) is the underlying cause of pancreatitis in 7% of the general population and is the third cause after gallstones and alcohol. HTG may be associated with acute pancreatitis as an epiphenomenon or as a precipitant thereof. Generally, more than 75% of pancreatitis induced by hypertriglyceridemia is due to secondary causes and although these are not sufficient to elevate triglycerides to cause pancreatitis, a preexisting defect is required to obtain a TG>1000 mg/dL to induce acute pancreatitis.

Material and Method:

To identify the prevalence morbidity and mortality of acute pancreatitis due to hypertriglyceridemia, a retrospective and cross-sectional observational clinical study was performed for a period of five years.

Results:

During the study period, 100 cases of acute pancreatitis of various etiologies were collected, 29 (29%) of which corresponded to acute pancreatitis of hypertriglyceridemic origin; history of risk: type 1 Diabetes mellitus one case (3.4%); Type 2 Diabetes mellitus 27 cases (24%); history of alcoholism nine cases (31%); positive smoking 4 cases (13.8%); hypertriglyceridemia 27 cases (94%); obesity 17 cases (59%); lipemic serum 19 cases (65.5%), and In-hospital stays average six days. Mortality in one case.

Discussion:

In the Mexican national survey of ENASUT 2012, it was found by age group that hypercholesterolemia is highest in the age groups of 50-69 years of age. (Table 1) The frequency of hyperlipidemia in patients with pancreatitis ranges from 12 to 38%, and of hypertriglyceridemia, between 4 and 53%; what is important is to define whether its presence is primary or causal, or secondary or consequence of other clinical conditions such as Diabetes mellitus, alcohol abuse, pregnancy or use of medications. The triglycerides were obtained on routine laboratory tests in our hospital and their values were steadily elevated and the hipertrigliceridemic acute pancreatitis is the principal cause instead the alcoholic acute pancreatitis.

Keywords: Pancreatitis acute;Hypertriglyceridemic; Prevalence; Morbidity; Mortality


Introduction
An association between lipid and pancreatic metabolism was observed many years ago.The appearance of milky serum during an acute pancreatitis (AP) attack was first recognized by Speck in 1846 [1].Hypertriglyceridemia (HTG) is the underlying cause of pancreatitis in 7% of the general population and is the third cause after gallstones and alcohol.HTG may be associated with acute pancreatitis as an epiphenomenon or as a precipitant thereof.Generally, more than 75% of pancreatitis induced by hypertriglyceridemia is due to secondary causes and although these are not sufficient to elevate triglycerides (TG) to cause pancreatitis, a preexisting defect is required to obtain a TG>1000 mg / DL to induce acute pancreatitis [2].

Material and Method
In order to identify the incidence of acute pancreatitis due to hypertriglyceridemia, a retrospective and cross-sectional observational clinical study was performed at Playa del Carmen Solidaridad Hospital, Quintana Roo.Mexico, for a period of 5 years (2012-2016).Risk factors for lipemic pancreatitis are diabetes mellitus, hypertriglyceridemia and systemic arterial hypertension.Admission criteria: acute inflammatory process of the pancreas accompanied by triglyceride levels between 500 and 999 m/dL and values>1000 mg/dL.(TG values<500 mg/dL were labeled as epiphenomena).The ultrasound is very deficient to assess the pancreatitis and, in our cases, showed it.As the study of image, we preferred the CTS because we allow staging the degree of pancreatitis.In the classification of the acute pancreatitis we include the Ranson, Acute Physiology and Chronic Health Evaluation II (APACHE II) and Glasgow scales and The CT severity index (CTSI) derived by Balthazar was used for description of CT findings in lipemic acute pancreatitis.The variables observed were: independent variables: diagnosis of pancreatitis, lipemic serum, serum amylase, lipase, triglycerides and total cholesterol.Dependent variables: age, sex, clinical history, severity ratings used, hospitalization days, morbidity and mortality.Statistic analysis Descriptive statistics were used; the qualitative variables were expressed in percentages; and the quantitative variables in means, medians and standard deviation.

Results
During the study period, 100 cases of acute pancreatitis of various etiologies were collected, 29 (29%) of which corresponded to acute pancreatitis of hypertriglyceridemic origin, of which 10 were female (34%) and   3) Admission to the intensive care unit 4 cases (14%).They received medical treatment 27 cases (96%) and surgical treatment in one case (4%); in-hospital stays average six days; morbidity 15 cases (51%) and mortality one case (4%).The hypertriglyceridemic pancreatitis acute obtained second place after of the pancreatitis acute biliary in this population.

Discusión
It is known that Mexico is suffering from an epidemic of overweight occupying the first places in the world it due to the change in the nutritional habits of an autochthonous feeding based on vegetal abundant in vegetal fiber towards a diet based on fast food rich in fats and sugars.It is well known that dyslipidemia is related to acute pancreatitis as a precipitating factor and as an epiphenomenon and according to Frederickson's classification, it is hyperlipoproteinemia type I or familial chylomicronemia syndrome, which is related to this entity and characterized by Deficiency of lipoprotein lipase (LPL) and apoC-II, which results in alterations in lipolysis and deep elevations in plasma chylomicrons.Under normal conditions chylomicrons are disintegrated and withdrawn from circulation within 12 hours and in patients with LPL deficiency the chylomicrons rich in triglycerides persist in the circulation for several days.In our cases, no diagnosis was included such as Frederickson type I hyperlipoproteinemia [3,4].
The frequency of hyperlipidemia in patients with pancreatitis ranges from 12 to 38%, and of hypertriglyceridemia, between 4 and 53%; what is important is to define whether its presence is primary or causal, or secondary or consequence of other clinical conditions such as Diabetes mellitus, alcohol abuse, pregnancy or use of medications.Thus, in our patients, no distinction was made between hypertriglyceridemia and hyperlipidemia.However, triglycerides were obtained on routine laboratory tests in our hospital and their values were steadily elevated [5,6].
Chengen, et al., [7] in their study on biliary pancreatitis and hypertriglyceridemia, found that when the latter is elevated, the prognosis is poor.In our patients, this association was not observed because when triglycerides were elevated and lipemic sera with negative ultrasound were seen for bile duct lithiasis, we classified them as triglyceride pancreatitis.Nawaz H, et al., [8] report that hypertriglyceridemia is independently associated with multiorgan failure, regardless of the etiology of pancreatitis.However, hypertriglyceridemia itself is an etiology of acute pancreatitis, which does not prevent triglycerides from elevating in cases of pancreatitis of other etiologies as a systemic response to pancreas aggression since normally diabetes mellitus and obesity are strongly associated with pancreatitis of lipemic origin.Regarding the severity of pancreatitis, Xu C, et al., [9] reports that fatty liver affects the severity of pancreatitis, however, in our series we found eight cases (28%) of hepatic steatosis diagnosed by ultrasound without important influence on the development of complications of acute pancreatitis, although it was related to the diagnosis of acute triglyceride pancreatitis.High levels of triglycerides as well as total cholesterol were key for the diagnosis of acute pancreatitis of lipid etiology, however, Tariq H, et al., [10] recommend this laboratory test as a predictor of complications; In our series 15 complicated cases (52%) in this series and one case of mortality, which indicates that this etiology is more serious than those of biliary or alcohol etiology [11].Other authors have apparently found normal laboratory results such as amylase and triglycerides at the beginning of the evaluation and should alert us in this respect not to subdivide this type of cases.[12].The prevalence of hypertriglyceridemic pancreatitis in a private hospital in Mexico City was 10% much lower than that found by us in our study, which was 29% and ranked second in frequency after biliary pancreatitis [13].With respect to the management of these patients Insulinstimulated lipoprotein lipase is known to decrease serum Triglyceride levels.Hence insulin is indicated in these cases [14].In a report by Tamez-Perez et al., [15] they used insulin.The dose used was 0.05 at 2 U/kg of body weight /hour.At an average of 2.5 days until the quantification of triglycerides were <400 mg / dL concluding that Insulin is a resource effective and safe treatment in patients with severe hypertriglyceridemia [16].Other authors handled insulin plus heparin infusion with similar results [17].Plasmapheresis is a treatment for pancreatitis due to hypertriglyceridemia that has shown its benefits in several studies.Same that it is not used routinely in our hospital and only in highly selected cases [18][19][20].On the other hand, one of the late complications of severe acute pancreatitis is the formation of pancreatic pseudocyst and in our case series we find only one case behaving in the same way as the case of Monib SM., et al [21].

Table 1 )
. Ultrasound diagnoses in a poor method for the diagnostic of acute pancreatitis in our hospital (Table2).CTS in 15

Table 1 :
Statistical analysis of laboratory tests in 29 cases of hypertriglyceridemic acute pancreatitis.

Table 2 :
Diagnoses by ultrasonography in 19 patients de 29 cases of hypertriglyceridemic acute pancreatitis.