Nanomaterials such as hydroxyapatite have been extensively researched, thanks to their unsual properties, which are similarin chemical composition to bone tissue. In addition, hydroxyapatite nanoparticles offer a wide range of possibilities forfunctionalization which make it an interesting material for target drug delivery applications, showing strong potential forcoupling natural substances such as curcumin to improve the antitumor effect of this substance in the fight against cancer.
Curcumin has been researched over the years, thanks to its anticancer properties. Hydroxyapatite also allows the incorporationof paramagnetic elements into their structure, such as gadolinium (Gd), allowing the production of a probe for diagnosticimaging using nuclear magnetic resonance imaging systems. In this work, hydroxyapatite nanorods (HA) doped withGd were synthesized to produce folic acid (FA) functionalized nanostructures for targeted delivery of curcumin (CM). Thesamples were characterized using various techniques, including Fourier transform infrared spectroscopy (FTIR), UV-visiblespectroscopy (UV-Vis), X-ray diffraction (XRD), thermogravimetric analysis (TGA), zeta potential analysis (ζ), transmissionelectron microscopy (TEM), and vibrating samples magnetometry (VSM). The results indicated a successful obtaining ofparamagnetic HA-Gd nanostructures functionalized with FA and CM, exhibiting characteristics that credit this system forfuture biological assays in order to evaluate their efficiency in the treatment and diagnosis of osteosarcoma
KCI 등재
A dual-functional gadolinium-conjugated hydroxyapatite nanoparticle-containing curcumin as a potential nanoplatform for bioapplications
Journal of Ceramic Processing Research
약어 : J. Ceram. Process. Res.
2023 vol.24, no.6, pp.983 - 991
DOI : 10.36410/jcpr.2023.24.6.983
발행기관 : 한양대학교 청정에너지연구소
연구분야 : 재료공학
Copyright © 한양대학교 청정에너지연구소
약어 : J. Ceram. Process. Res.
2023 vol.24, no.6, pp.983 - 991
DOI : 10.36410/jcpr.2023.24.6.983
발행기관 : 한양대학교 청정에너지연구소
연구분야 : 재료공학
Copyright © 한양대학교 청정에너지연구소
Jéssica Pauline Nunes Marinho
1
,
Marcelo Fernandes Cipreste
2
,
Alisson Krohling
3
,
Edésia Martins Barros Sousa
4
1Centro de Desenvolvimento da Tecnologia Nuclear
2JHS Biomateriais. Rua Ouro Branco
3Centro de Desenvolvimento da Tecnologia Nuclear
4Centro de Desenvolvimento da Tecnologia Nuclear
Hydroxyapatite nanorods, Folate functionalization, Theranostics, Magnetic properties, Curcumin
* 2023년 이후 발행 논문의 참고문헌은 현재 구축 중입니다.
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A dual-functional gadolinium-conjugated hydroxyapatite nanoparticle-containing curcumin as a potential nanoplatform for bioapplications
@article{ART003033200},
author={
Jéssica Pauline Nunes Marinho
and
Marcelo Fernandes Cipreste
and
Alisson Krohling
and
Edésia Martins Barros Sousa
},
title={
A dual-functional gadolinium-conjugated hydroxyapatite nanoparticle-containing curcumin as a potential nanoplatform for bioapplications
},
journal={
Journal of Ceramic Processing Research
},
issn={1229-9162},
year={2023},
number={6},
pages={983 - 991},
doi={10.36410/jcpr.2023.24.6.983},
url={http://dx.doi.org/10.36410/jcpr.2023.24.6.983}
TY - JOUR
AU - Jéssica Pauline Nunes Marinho
AU - Marcelo Fernandes Cipreste
AU - Alisson Krohling
AU - Edésia Martins Barros Sousa
TI - A dual-functional gadolinium-conjugated hydroxyapatite nanoparticle-containing curcumin as a potential nanoplatform for bioapplications
T2 - Journal of Ceramic Processing Research
PY - 2023
VL - 24
IS - 6
PB - 한양대학교 청정에너지연구소
SP - 983 - 991
SN - 1229-9162
AB - Nanomaterials such as hydroxyapatite have been extensively researched, thanks to their unsual properties, which are similarin chemical composition to bone tissue. In addition, hydroxyapatite nanoparticles offer a wide range of possibilities forfunctionalization which make it an interesting material for target drug delivery applications, showing strong potential forcoupling natural substances such as curcumin to improve the antitumor effect of this substance in the fight against cancer.
Curcumin has been researched over the years, thanks to its anticancer properties. Hydroxyapatite also allows the incorporationof paramagnetic elements into their structure, such as gadolinium (Gd), allowing the production of a probe for diagnosticimaging using nuclear magnetic resonance imaging systems. In this work, hydroxyapatite nanorods (HA) doped withGd were synthesized to produce folic acid (FA) functionalized nanostructures for targeted delivery of curcumin (CM). Thesamples were characterized using various techniques, including Fourier transform infrared spectroscopy (FTIR), UV-visiblespectroscopy (UV-Vis), X-ray diffraction (XRD), thermogravimetric analysis (TGA), zeta potential analysis (ζ), transmissionelectron microscopy (TEM), and vibrating samples magnetometry (VSM). The results indicated a successful obtaining ofparamagnetic HA-Gd nanostructures functionalized with FA and CM, exhibiting characteristics that credit this system forfuture biological assays in order to evaluate their efficiency in the treatment and diagnosis of osteosarcoma
KW - Hydroxyapatite nanorods, Folate functionalization, Theranostics, Magnetic properties, Curcumin
DO - 10.36410/jcpr.2023.24.6.983
UR - http://dx.doi.org/10.36410/jcpr.2023.24.6.983
ER -
Jéssica Pauline Nunes Marinho , Marcelo Fernandes Cipreste , Alisson Krohling and Edésia Martins Barros Sousa (2023). A dual-functional gadolinium-conjugated hydroxyapatite nanoparticle-containing curcumin as a potential nanoplatform for bioapplications. Journal of Ceramic Processing Research, 24(6), 983 - 991.
Jéssica Pauline Nunes Marinho , Marcelo Fernandes Cipreste , Alisson Krohling and Edésia Martins Barros Sousa . 2023, “A dual-functional gadolinium-conjugated hydroxyapatite nanoparticle-containing curcumin as a potential nanoplatform for bioapplications”, vol.24, no.6, pp. 983 - 991. Available from: doi:10.36410/jcpr.2023.24.6.983
Jéssica Pauline Nunes Marinho 외. “A dual-functional gadolinium-conjugated hydroxyapatite nanoparticle-containing curcumin as a potential nanoplatform for bioapplications“ Journal of Ceramic Processing Research 24.6 pp. 983 - 991. (2023): 983.
Jéssica Pauline Nunes Marinho , Marcelo Fernandes Cipreste , Alisson Krohling , Edésia Martins Barros Sousa . A dual-functional gadolinium-conjugated hydroxyapatite nanoparticle-containing curcumin as a potential nanoplatform for bioapplications Journal of Ceramic Processing Research [Internet]. 2023; 24(6), : 983 - 991. Available from: doi:10.36410/jcpr.2023.24.6.983
Jéssica Pauline Nunes Marinho , Marcelo Fernandes Cipreste , Alisson Krohling and Edésia Martins Barros Sousa . “A dual-functional gadolinium-conjugated hydroxyapatite nanoparticle-containing curcumin as a potential nanoplatform for bioapplications“ Journal of Ceramic Processing Research 24, no.6, (2023): 983 - 991. doi: :10.36410/jcpr.2023.24.6.983