초록

Biphasic calcium phosphate (BCP) bone grafts were successfully synthesized using the 45 ppi polyurethane sponge coatingmethod. XRD results revealed that the BCP scaffolds were mainly composed of hydroxyapatite and β-tricalcium phosphate(β-TCP). As the number of BCP coatings increased from 1 to 5, the pore size and the wall size decreased from 480 ± 93 μmto 306 ± 120 μm and increased from 104 ± 25 μm to 186 ± 40 μm, respectively. The BCP scaffolds coated once, twice, threetimes, four times and five times, exhibited average cell viability of 106%, 109%, 114%, 107%, and 93%. The BCP scaffoldsshowed no evidence of causing cell lysis or toxicity. In addition, the cell proliferation results suggested that L-929 cells adheredwell to the BCP scaffolds and proliferated continuously with increasing time, indicating that the BCP powders are highlyapplicable to the synthetic bone grafts.

키워드

Hydroxyapatite (HP), β-tricalcium phosphate (β-TCP), Biphasic calcium phosphate (BCP), Scaffold, Cytotoxicity

참고문헌(8)open

  1. [학술지] 송호연 / 2007 / 마이크로웨이브법에 의해 제조된 HAp 및 BCP 분말이 뼈모세포 및 파골세포의 활성에 미치는 영향 / 한국재료학회지 17 (12) : 669 ~ 675

  2. [학술지] 김영희 / 2008 / Effects of Macrophage on Biodegradation of β-tricalcium Phosphate Bone Graft Substitute / 한국세라믹학회지 45 (10) : 618 ~ 624

  3. [학술지] 장명철 / 2016 / Use of Wet Chemical Method to Prepare β Tri-Calcium Phosphates having Macro- and Nano-crystallites for Artificial Bone / 한국세라믹학회지 53 (6) : 670 ~ 675

  4. [학술지] 강태성 / 2017 / Fabrication of Calcium Phosphate Glass Using Eggshell and its Crystallization Behavior / 한국세라믹학회지 54 (5) : 395 ~ 399

  5. [학술지] 김진태 / 2015 / Effect of surface-treatments on flexibility and guided bone regeneration of titanium barrier membrane / 한국결정성장학회지 25 (3) : 98 ~ 104

  6. [학술지] 손시원 / 2015 / 다공성 폴리(ε-카프로락톤)/실리카 복합체의 제조 및 특성평가 / 폴리머 39 (2) : 323 ~ 328

  7. [학술지] 김예나 / 2016 / Effect of PEG Addition on Pore Morphology and Biocompatibility of PLLA Scaffolds Prepared by Freeze Drying / Biomedical Engineering Letters (BMEL) 6 (4) : 287 ~ 295

  8. [학술지] 설보경 / 2017 / 전기방사법으로 제조한 PU/PEG 복합 지지체의 특성 / 의공학회지 38 (5) : 248 ~ 255