Clinical Presentation and Risk Assessment of Ovarian Tumors in Baghdadian Women

Background: Ovarian cancer is the fourth leading cause of cancer death in women; median age at diagnosis is 63 years. It is highly curable if diagnosed at an early stage, but 75% of its present with stage III or IV disease. Many risk factors have been identified for ovarian cancer like the lifetime ovulatory cycles. The study aimed to define the different presenting signs and symptoms for ovarian cancer, outline the main risk factors responsible for ovarian cancer, and discuss the important points helpful for the prevention and decrease incidence.


INTRODUCTION
Ovarian cancer is primarily a disease of postmenopausal women, with the large majority of cases occurring in women between 50 and 75 years old. The incidence of ovarian cancer increases with age and peaks at a rate of 61.5 per 100,000 women in the 75-79-year-old age group [1]. The etiology of ovarian cancer is not fully understood, and numerous studies have attempted to demonstrate possible links between environmental, dietary, reproductive, endocrine, viral, and hereditary factors and the risk of developing ovarian cancer.
So far, the strongest risk factor for ovarian cancer is a familial pattern, reported in about 7% of women with the disease [2].
These tumours usually present late and only one-third are localized at the time of diagnosis. Early ovarian cancer is often asymptomatic. When symptoms occur they are often vague and are overlooked by patients, even when the tumour is locally advanced and abdominal distension has become obvious.
Lower abdominal pain, bloating and anorexia are common, but often insufficient to raise suspicion [3]. The CA 125 serum level is elevated in more than 80% of serous epithelial ovarian cancers. However, it is not a reliable diagnostic test, since it can also be elevated in a variety of benign gynecologic conditions (such as endometriosis, pelvic inflammatory disease, or pregnancy) and non-gynecologic malignancies (such as breast, lung, and gastrointestinal cancers). Transvaginal ultrasonography (TVU) is an important diagnostic tool in the evaluation of patients with a pelvic mass [4]. Computed tomography (CT) or magnetic resonance imaging (MRI) may sometimes be helpful in defining the extent of peritoneal disease in patients with suspected ovarian cancer. Chest radiographs may sometimes be performed to evaluate the presence of pleural effusions, which occur in 10% of patients with epithelial ovarian cancer at diagnosis [5]. However, there is currently no proven role for positron emission tomography (PET) in the diagnosis or subsequent follow-up of patients with ovarian cancer [6].
The majority of ovarian malignancies, 65% to 70%, are epithelial, with germ cell tumors (25%), sex cord stromal (5%), and metastases to the ovary (5%) accounting for the remainder. Serous tumors are most common, comprising 40% to 50% of epithelial tumors. Clinically, the mucinous tumors can be very large and can be associated with mucinous tumors of the appendix; therefore, appendectomy is recommended, particularly if the tumor is right-sided [7].
For both early-and advanced-stage ovarian cancer, surgery is the mainstay of diagnosis and initial treatment and this can be accomplished via laparotomy or via minimally invasive techniques (laparoscopy, robotic assistance). Upfront maximal cyto-reduction with the goal of no residual disease should be undertaken, and when primary cyto-reductive surgery is not possible, it should be considered after three to five cycles of chemotherapy in patients who do not have progressive disease [8].
Numerous studies suggest that patients with low-risk, lowgrade, early-stage disease do not require adjuvant therapy after definitive surgery has been performed. However, this is a small percent of the women who present with epithelial ovarian cancer, and in all other women, surgery alone is not curative. Platinum compounds offer improved survival rates over non-platinum regimens [9].
Because of the unique intraperitoneal dissemination of epithelial ovarian cancer, there has been a significant interest in evaluating intraperitoneal administration of chemotherapy [10].
Regarding management of non-epithelial tumors pretreatment alpha fetoprotein (AFP) and B-human chorionic gonadotropin (B-hCG) levels are of particular importance in diagnosis and treatment. Variations in surgical management and adjuvant chemotherapy and radiation do exist among the non-epithelial tumors. Treatments should consider the patient's desire to maintain fertility while offering the greatest chance for cure [11].

Study design and setting
In this retrospective study, thirty one female patients with history of ovarian cancer were studied for the variations in clinical presentations and for the assessment of the main risk factors of ovarian cancer.
These patients were seen in Alamal National Hospital for Cancer Management by many oncologists in this hospital in the period between September 2012 and June 2013 and this is the duration of this study.

Participants and data collection
The patients were diagnosed with ovarian cancer depending on the histopathological tests and the patients were subjected to different types of surgical intervention as part of the common type of ovarian cancer and of which serous subtype considered the main subtype.

Statistical analysis
The statistical analysis was performed using descriptive methods for normal distribution data by obtained frequencies, and percentage.

Socio-demographic variables
In our study, 31 female already diagnosed with ovarian cancer were studied for the presenting signs and symptoms and for the main risk factors for the development of ovarian cancer.
Age distribution in the studied group of patients was divided into 2 groups and the age limit was 50 years as shown in Table 1. Regarding menstrual history in the studied group of patients, the age of menarche for all patients was in the range of (11-14) years while only 1 patient had a history of irregular menstrual cycle. In the studied sample of patients, 10 patients are nullipara while the remaining are multipara, as shown in Table 2. Family history of ovarian cancer was positive in 3 patients in the study as shown in Table 3. The use of hormonal treatment in the form of contraceptive pills was found in 13 patients of the studied sample as shown in Table 4.

Ovarian cancer variables
The presenting signs and symptoms in the studied sample of patients were divided depending on history taken from the patients as shown in Table 5. In this study the number of patients that had metastasis at time of diagnosis was 17 as shown in Table 6. Depending on histopathological reports of the primary tumor of the studied sample of patients, different tumor types appeared as shown in Table 7.

DISCUSSION
This study was a retrospective study which mainly concentrated on the clinical presentation and main risk factors of ovarian cancer and in this study the age distribution for ovarian cancer was mainly in the age group of ≥ 50 years as there were sixteen patients (51.6%) in this age group and this result is consistent with a study conducted by Stephen C.
and colleagues which stated that Ovarian cancer is primarily a disease of postmenopausal women, with the large majority of cases occurring in women between 50 and 75 years old [1].
Another study published in the National Cancer Intelligence Network which stated that the age-specific incidence rates rise steadily with age, peaking among women in their 70s and 80s. The numbers of cases are highest among women in their 60s and 70s, accounting for almost half the diagnoses [12].
Nulliparity was found to be a risk factor for the incidence of ovarian cancer in the studied group of patients as ten patients were nullipara (32.3%) and this result disagreed with a study done by Bristow et al. which stated that nulliparity is associated with an increased risk of ovarian cancer [13].
Three patients (9.68%) in this study had a family history of ovarian cancer, and this is inconsistent with a study conducted by Cook, 2002 which stated that Women with one first-degree relative with ovarian cancer have a 5 % lifetime risk and women with two or more first-degree relatives have a 7 % risk. The risk is greater for the sisters and daughters than for the mother [14]. Another study done by Risch et al. confirmed this result and it stated that after controlling for age, the strongest risk factor for ovarian cancer is a family history of ovarian cancer and the incidence of ovarian cancer attributable to genetic factors is estimated to be in the range of 5 to 10% [15].
The use of oral contraceptive pills is considered as a protective factor against the development of ovarian cancer and in our study eighteen patients (58.0 %) with ovarian cancer were not using contraceptive pills and this result is confirmed by a study conducted by Purdie et al. which stated that The association between female reproductive organ cancer and use of OCP has been studied for decades, with OCP consistently shown to reduce the risk of ovarian cancer. Ever use of OCP has been shown to decrease ovarian cancer risk by 40 to 50% compared with never use [16]. Another study which confirmed this issue was conducted by Schlesselman and colleagues and it stated that the risk of ovarian cancer is reduced by 40%, 53%, and 60% with oral contraceptive use for 4, 8, and 12 years, respectively [17]. involving the pelvis and upper abdomen [24,25].

CONCLUSIONS
The incidence of ovarian cancer was mainly in the age group of ≥ 50 years. Nulliparity was found in (32.3%), thus, it was considered a risk factor for the development of ovarian cancer.
The use of OCP is considered a protective factor against the development of ovarian cancer. Most of the cases presented in advanced stage at time of diagnosis as metastatic ovarian cancer. Epithelial tumors comprise the most common type of ovarian cancer and of which serous subtype considered the main subtype.

Encouraging women for continuous gynecologic evaluation
for early detection of any ovarian tumor especially for patients with family history of ovarian cancer.
2. Encouraging women for child bearing as nulliparity is considered a risk factor for ovarian cancer.

Conflict of interest
There is no conflict of interest and this research has not been funded by any organization.