Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction

An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed. The process involves kinetic resolution, with the axially chiral aryl monoaldehydes obtained in moderate yields with excellent optical purities. These axially chiral aryl monoaldehydes can be conveniently transformed into functionalized molecules, showing great potential as catalysts in organic chemistry.

We recently converted monoaldehydes to the corresponding nitriles with axial chirality controlled [51].
Here, we disclose that through NHC-catalyzed nitrile formation, a desymmetrization/dynamic kinetic resolution process can be achieved and transfers symmetric dicarbaldehydes to axially chiral aryl monoaldehydes (Fig. 1B).Products from our approach containing cyanide and aldehyde groups are potential catalysts in organocatalysis.In contrast to earlier more conventional aldehyde conversions (such as ester formation), we hope our study encourages further exploration in innovating the NHC-catalyzed aldehyde-to-nitrile process for new applications.

Results
We initially employed biaryl dialdehyde (1a) and readily available p-toluenesulfinate (TsNH 2 , 2) as model substrates to screen reaction conditions for this transformation (Table ).Subsequently, we performed a screening of various indanolderived NHC pre-catalysts in the presence of NHEt 2 in dichloroethane (DCE) solvent (Table, entries 1 to 3).Notably, the utilization of NHC pre-catalyst A [52] featuring the N-Mes group in this process could only generate a trace amount of the axially chiral aryl monoaldehyde 3a (entry 1).However, the product 3a could be given in moderate yields while utilizing NHC pre-catalysts B and C [53,54] (entries 2 and 3).Additionally, we observed the formation of a by-product biaryl dicarbonitrile 4 during this transformation process.Considering the impact of bases on nitrile formation during NHC catalysis, we conducted additional screening of various bases.
However, when NHC pre-catalyst B was employed, the use of alternative bases resulted in a notable decrease on the product enantiomeric ratio (er) values (entries 4 to 7).Regrettably, our attempts to improve the results by screening various nonpolar and polar organic solvents did not yield positive outcomes (entries 8 to 11).However, it is worth noting that increasing the quantity of substrate 2 (TsNH 2 ) resulted in a slight increase in yields and importantly improved the er values of product 3a.Moreover, in these cases, a nonchiral dicarbonitrile by-product 4 was obtained, with yields ranging from 18% to 21% (entries 12 and 13).Finally, when a 4-Å molecular sieve (MS) was used as the additive in the 1.0 mL of DCE, the target axially chiral product 3a was obtained in 63% yield and >99:1 er value (entry 14).
When the optimized reaction condition was obtained (Table, entry 14), we further explored the substrate scope of the atropoenantioselective nitrile formation process using a variety of biaryl dialdehydes 1 (Fig. 2).Whether one or two methyl groups are installed in ring A, with the corresponding aryl monoaldehydes obtained in improved yields with no erosion of the product er values (3b to 3e).However, the electrondonating group 4′-OCH 3 introduced in ring A led to a lower enantioselectivity (3f).The halogen (F, Cl) could be attached to ring A of the benzaldehydes 1 to give corresponding products in moderate yields with retaining high optical purities (3g to 3j).Notably, the presence of 5′-Cl of ring A in the biaryl dialdehyde resulted in a lower er value of aryl aldehyde product 3k, albeit with a moderate yield.The 2′-methyl group on ring A played an important role in restricting axial rotation.For instance, when ethyl, -SMe, or alkenyl groups were incorporated at the 2′-position of ring A, the product yields of the aryl monoaldehydes were slightly changed (3l to 3n).Moreover, an obvious reduction in both product yields and er values could be observed when the 2′-halogen or 2′-phenyl group was introduced to ring A (3o to 3q).Furthermore, the NHCcatalyzed atropoenantioselective reaction exhibited promising performance even in the presence of aromatic fused rings in the dialdehydes, and all the corresponding aryl monoaldehydes could be obtained with excellent optical purities (3r to 3t).However, a slight decrease in the product er value occurred when 2′-CH 3 O-naphthyl was used to replace ring A (3u).In addition, we also tested substrate scope on the dialdehyde aromatic ring (ring B).Electron-donating (OMe) and halogen (F) Table.Optimized conditions.Unless otherwise specified, the reactions were carried out using 1a (0.12 mmol), 2 (0.10 mmol), NHC (0.02 mmol), base (0.12 mmol), 4 Å MS (50 mg), and solvent (2.0 ml) at 40  groups were tolerated well and given corresponding aryl monoaldehyde products 3v and 3w in moderate yields and excellent er values.The stereochemical stability of the axially chiral biaryl aldehyde product 3a was then evaluated through the previous experimental approach [55-57] (Fig. 3).The procedure involved stirring the compound in mesitylene at 120 °C for 7 h.Con sequently, a nearly racemic mixture of the targeted product 3a was obtained.By analyzing the rate of change in product enantiomeric excess (ee) values at 120 °C, it was possible to ascertain the rotational barrier to the axially chiral compound 3a.On the basis of the changing rate of product ee values at 120 °C, the rotational barrier of the axially chiral compound 3a was determined (ΔG # = 30.95kcal/mol).Additionally, based on this barrier energy, a half-life to racemization at 120 °C was calculated and the half-life of product 3a is 1.92 h.
It is worth noting that this transformation can be put into practice at 5-mmol scales, resulting in the aryl aldehyde product 3a in 65% yield and >99:1 er value.The enantiomerically enriched axially chiral product 3a, containing both aldehyde and nitrile units, can serve as a potential catalyst in the aldehydecatalyzed asymmetric reaction and could also be easily derived into a variety of functionalized molecules through simple protocols (Fig. 4).Aryl aldehyde product 3a could react with Wittig reagent to generate the axially chiral alkene product 5. Subsequently, the CN group of compound 5 can be reduced to an aldehyde group in 86% yield and >99:1 er value.Moreover, the optically enriched 3a could be efficiently reduced by NaBH 4 to give alcohol 7 in quantitative yield with no erosion of optical purities.Then, the OH group of 7 can be substituted by the chloro group to form an unexpected product 8 in 70% yield with excellent enantioselectivity in this transformation.Furthermore, in the presence of potassium permanganate, compound 3a undergoes oxidation process to give axially chiral carboxylic acid 9 in good yield while maintaining its excellent optical purity.This axially chiral carboxylic acid 9 can be effectively employed as an organic catalyst for acid-catalyzed asymmetric reactions [58][59][60][61][62][63][64].
It is worth noting that the formation of the intermediate (±)-10a is a reversible process from TsNH 2 with aldehydes [65].The formation of by-product 4a could affect the target product er values in this process (Table , entries 2, 12, and 13).Subsequently, we performed a control experiment using (rac)-3a as the starting material under standard conditions.In this control experiment (Fig. 5A), (S)-3a was obtained with a yield of 51% and an 82:18 er value.It is worth noting that by-product 4a was also generated in 45% yield.This result demonstrated that the kinetic resolution is critical for the product optical purity.Based on the experimental observation together with the reported literature [32,[66][67][68][69][70][71], a proposed reaction pathway is depicted in Fig. 5B.First of all, the condensation of biaryl dialdehyde 1a with TsNH 2 is generated to afford a racemic mixture of imines (±)-10a, then (S)-10a undergoes a faster desulfonylation reaction to give the corresponding atropisomeric benzaldehyde product (S)-3a in excellent enantioselectivity enabled by a chiral NHC catalyst.On the other hand, (R)-10a was dynamically hydrolyzed at a slower reaction rate than the starting material 1a.This process is desymmetrization/dynamic kinetic resolution, leading to the formation of the by-product 4a and improved enantioselectivity of product 3a, accompanied by the consumption of (R)-3a.

Discussion
We have developed an atropoenantioselective NHC-catalyzed nitrile formation and desymmetrization reaction.Various substituents can be tolerated well, with the corresponding aryl monoaldehydes afforded in moderate to good yields and good to excellent er values.The stereochemical stability of aryl aldehyde has been assessed using thermal dynamic methods.Notably, this synthetic protocol is well-suited for large-scale synthesis, and the resulting products, containing both aldehyde and nitrile functional groups, can be conveniently transformed into diverse functional molecules without marked loss of optical purities.As we continue our research, we aim to explore further synthetic applications for these atropoisomerically enriched aryl monoaldehydes.
°C under N 2 for 24 h.