Mitochondrial K+ Transport: Modulation and Functional Consequences
Abstract
:1. Introduction
2. The K+ Cycle
3. Activating MitoKATP
3.1. Pharmacological MitoKATP Activators
3.2. Physiological MitoKATP Modulation
3.3. Physiological Consequences of MitoKATP Opening
3.4. Beneficial Effects of MitoKATP Activators under Pathological Conditions
4. Inhibiting MitoKATP
5. Modulation of the Mitochondrial K+/H+ Exchanger
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Sample Availability
References
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Compound Name | Effective Concentrations (μM) | References |
---|---|---|
Diazoxide | 30 | Garlid et al., 1997 [15] |
Pinacidil | 100 | Crestanello et al., 2000 [40] |
Nicorandil | 100 | Teshima et al., 2003 [41] |
Cromakalim | 30 | Garlid et al., 1997 [15] |
BMS191095 | 10 | Grover et al., 2001 [38] |
p-diethylaminoetylbenzoate | 100 | Mironova et al., 2004 [39] |
phorbol 12-myristate 13-acetate (PMA) | 0.2 | Sato et al., 1998 [42] |
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Pereira, O., Jr.; Kowaltowski, A.J. Mitochondrial K+ Transport: Modulation and Functional Consequences. Molecules 2021, 26, 2935. https://doi.org/10.3390/molecules26102935
Pereira O Jr., Kowaltowski AJ. Mitochondrial K+ Transport: Modulation and Functional Consequences. Molecules. 2021; 26(10):2935. https://doi.org/10.3390/molecules26102935
Chicago/Turabian StylePereira, Osvaldo, Jr., and Alicia J. Kowaltowski. 2021. "Mitochondrial K+ Transport: Modulation and Functional Consequences" Molecules 26, no. 10: 2935. https://doi.org/10.3390/molecules26102935