Asymmetric Transfer Hydrogenation of Arylketones Catalyzed by Enantiopure Ruthenium(II)/Pybox Complexes Containing Achiral Phosphonite and Phosphinite Ligands

A family of complexes of the formula trans-[RuCl2(L)(R-pybox)] (R-pybox = (S,S)-iPr-pybox, (R,R)-Ph-pybox, L = monodentate phosphonite, PPh(OR)2, and phosphinite, L = PPh2(OR), ligands) were screened in the catalytic asymmetric transfer hydrogenation of acetophenone, observing a strong influence of the nature of both the R-pybox substituents and the L ligand in the process. The best results were obtained with complex trans-[RuCl2{PPh2(OEt)}{(R,R)-Ph-pybox}] (2c), which provided high conversion and enantioselectivity (up to 96% enantiomeric excess, e.e.) for the reduction of a variety of aromatic ketones, affording the (S)-benzylalcohols.

We have also made some contributions in this field, particularly on the synthesis and catalytic activity of group 8 metal complexes based on enantiopure N,N,N-ligands, lacking the N-H functionality. In this context, we reported the complexes cis-[MCl 2 (L)(R-pybox)] (M = Ru, Os, L = phosphane) and trans-[MCl 2 (L)(R-pybox)] (M = Ru, L = phosphane, phosphite; M = Os, L = phosphite) and studied their catalytic activity toward the asymmetric transfer hydrogenation of aryl ketones. Interestingly, the efficiency of these catalysts depends not only on the metal and the chiral ligand but also on the nature of the auxiliary P-donor ligand [19,20]. Thus, we found that the reduction of different aryl ketones was best achieved using the combination of Ru(II)/(R,R)-Ph-pybox/phosphane (95%-99% conversion; up to and studied their catalytic activity toward the asymmetric transfer hydrogenation of aryl ketones. Interestingly, the efficiency of these catalysts depends not only on the metal and the chiral ligand but also on the nature of the auxiliary P-donor ligand [19,20]. Thus, we found that the reduction of different aryl ketones was best achieved using the combination of Ru(II)/(R,R)-Ph-pybox/phosphane (95%-99% conversion; up to 95% e.e.) and Os(II)/(S,S)i Pr-pybox)/phosphite (96%-99% conversion; up to 94% e.e.). However, the corresponding phosphite ruthenium and phosphane osmium complexes led to lower enantiomeric excess. The influence of the P-donor ligand was also analyzed by Beller and col. using mixtures of [RuCl2(η 6 -C6H6)]/pybim and monodentate or bidentate phosphanes as the catalyst [15]. In the light of these findings, we found of interest to move to explore further combinations of ruthenium/osmium complexes with other phosphorous ligands with different electronic demand and steric requirement.
Moreover, this stereochemistry had been confirmed by single-crystal X-ray analysis for complexes 1a and 2c. An ORTEP-type view of these complexes is shown in Figure 1 (thermal ellipsoids were Molecules 2020, 25, 990 3 of 9 shown at the 30% probability level, and hydrogen atoms were omitted for clarity), and selected bonding data are collected in the Table S1 (Supporting Information).

Catalytic Asymmetric Transfer Hydrogenation of Ketones
Then, the above-reported complexes were tested towards the ATH of acetophenone. Thus, Table 1 summarizes the conversion of acetophenone into enriched 1-phenylethanol using the ruthenium(II) (S,S)-i Pr-pybox) (1) and (R,R)-Ph-pybox (2) catalysts. The electronic nature and steric demand [24,25] (Tolman electronic parameter (TEP) and cone angles) of the achiral auxiliary phosphonite and phosphinite ligands used in this report were between those of the phosphane and phosphite ligands, already studied by us in the ATH of ketones [19]. ellipsoids were shown at the 30% probability level, and hydrogen atoms were omitted for clarity), and selected bonding data are collected in the Table S1 (Supporting Information).

Catalytic Asymmetric Transfer Hydrogenation of Ketones
Then, the above-reported complexes were tested towards the ATH of acetophenone. Thus, Table  1 summarizes the conversion of acetophenone into enriched 1-phenylethanol using the ruthenium(II) (S,S)i Pr-pybox) (1) and (R,R)-Ph-pybox (2) catalysts. The electronic nature and steric demand [24,25] (Tolman electronic parameter (TEP) and cone angles) of the achiral auxiliary phosphonite and phosphinite ligands used in this report were between those of the phosphane and phosphite ligands, already studied by us in the ATH of ketones [19].
In a typical experiment, the ruthenium catalyst precursor 1,2 (0.01 mmol, 0.2 mol%) was added to a solution containing 5 mmol of acetophenone in 45 mL of 2-propanol under an argon atmosphere, and the solution was stirred initially for 15 min at 82 °C. After this time, a solution of 0.24 mmol of KO t Bu in 5 mL of 2-propanol (ketone/catalyst/KO t Bu ratio = 500:1:24) was added, and the resulting mixture was heated for 15 min and then monitored by gas chromatography using a chromatograph with a Supelco β-DEX 120 chiral capillary column (90 min of stirring time was used in some instances; see Table 1, entries 2,6,8). In a typical experiment, the ruthenium catalyst precursor 1,2 (0.01 mmol, 0.2 mol%) was added to a solution containing 5 mmol of acetophenone in 45 mL of 2-propanol under an argon atmosphere, and the solution was stirred initially for 15 min at 82 • C. After this time, a solution of 0.24 mmol of KO t Bu in 5 mL of 2-propanol (ketone/catalyst/KO t Bu ratio = 500:1:24) was added, and the resulting mixture was heated for 15 min and then monitored by gas chromatography using a chromatograph with a Supelco β-DEX 120 chiral capillary column (90 min of stirring time was used in some instances; see Table 1, entries 2, 6,8).
Therefore, once the basic reaction conditions were defined, we carried out the optimization of the reduction of acetophenone using the complex [RuCl 2 {PPh 2 (OEt)}(Ph-pybox)] (2c) as catalyst ( Table 2). The following parameters were explored: i) Catalyst loading (entries 1-4): First of all, the amount of catalyst was varied in the range of 0.1-0.4 mol% (entries 1-4), starting from the basic reaction conditions (entry 1; ketone/KO t Bu ratio of 500:24; 50 mL of 2-propanol). The highest e.e. value was obtained when 0.3 mol% of catalyst was employed (entry 3). Lower ratio of catalyst (0.2 and 0.1 mol%; entries 1-2) required longer reaction times and/or led to poorer enantiomeric excess, while a little decrease of the e.e. was observed with 0.4 mol% of catalyst (entry 4). ii) Concentration (entries 5, 6): Then, we studied the effect of the amount of 2-propanol and found a notable improvement of both conversion and enantioselectivity as the total amount of 2-propanol increased from 50 mL (entry 3) to 75 mL (entries 5, 6). iii) Base (entries 5-11): Taking the entries 5, 6 as the reference, some other bases were explored (entries 7-11). We found that KO t Bu, NaOH, and NaO t Bu behaved more efficiently than KOH and Cs 2 CO 3 (entries 5-9 vs. 10, 11). Among the former, the base NaO t Bu seemed to be slightly superior (entries: 8, 9 vs. 5, 6). iv) Ketone/catalyst/NaO t Bu ratio (entries 8, 12, 13): Decreasing the ratio of base from 500:1.5:24 (entry 8) to either 500:1.5:12 or 500:1.5:6 (entries 12, 13) resulted in a slightly higher e.e. a Reactions were carried out at 82 • C using 5 mmol of acetophenone. b Determined by GC with a Supelco β-DEX 120 chiral capillary column.
Once the reduction of acetophenone was optimized using 2c as a catalyst [26], the ATH of a number of aryl ketones was studied, and the results are gathered in Table 3. In most cases, the reaction required short reaction time (5-10 min) and took place with high conversion (around 90%) and excellent enantioselectivity (87%-96% e.e.). Thus, this pattern was observed for acetophenone, propiophenone, and 2-acetonaphthone (entries 1, 2 and 3), as well as for electron-rich 3-and 4-methoxyacetophenone (entries 4 and 5) (3000-4000 TOF) [27]. On the other hand, increasing the steric demand of the substrate, particularly that of the aryl group, had a great impact on the process in terms of both conversion and enantiomeric excess. Thus, although the reduction of 2-methoxyacetophenone (entries 6 and 7) was rather inefficient, isobutyrophenone could be transformed into the alcohol with high enantiomeric excess and moderate (entry 8) or good conversion (entry 9). terms of both conversion and enantiomeric excess. Thus, although the reduction of 2methoxyacetophenone (entries 6 and 7) was rather inefficient, isobutyrophenone could be transformed into the alcohol with high enantiomeric excess and moderate (entry 8) or good conversion (entry 9). Complexes 1 and 2 fulfilled the requirement to be precursors of active species in the catalytic asymmetric transfer hydrogenation of ketones by hydrogen transfer from i PrOH/base. Regarding the stereochemical outcome, the observed results were in accordance with the established reaction pathway [28][29][30][31]. Thus, the hydrogen transfer step had been proposed to occur through a fourmembered cyclic transition state, involving the metal-hydride and the ketone. Such a transition state would result from i) chloride extraction and metal isopropoxide formation, ii) generation of metal hydride by β-elimination of propanone (an inner-sphere mechanism), iii) loss of the second chloride to generate a 16-electron metal hydride, iv) coordination of metal hydride and ketone. Then, the approach of the ketone to the metal-hydride complex could occur in two ways, involving the re-face or si-face of the ketone. Figure 2 illustrates the transition states in the case of (R,R)-pybox complexes, showing that the steric repulsions of the oxazoline-and ketone-phenyl groups make transition state A lower in energy than transition state B, providing the (S)-alcohols preferentially [19,32]. terms of both conversion and enantiomeric excess. Thus, although the reduction of 2methoxyacetophenone (entries 6 and 7) was rather inefficient, isobutyrophenone could be transformed into the alcohol with high enantiomeric excess and moderate (entry 8) or good conversion (entry 9). Complexes 1 and 2 fulfilled the requirement to be precursors of active species in the catalytic asymmetric transfer hydrogenation of ketones by hydrogen transfer from i PrOH/base. Regarding the stereochemical outcome, the observed results were in accordance with the established reaction pathway [28][29][30][31]. Thus, the hydrogen transfer step had been proposed to occur through a fourmembered cyclic transition state, involving the metal-hydride and the ketone. Such a transition state would result from i) chloride extraction and metal isopropoxide formation, ii) generation of metal hydride by β-elimination of propanone (an inner-sphere mechanism), iii) loss of the second chloride to generate a 16-electron metal hydride, iv) coordination of metal hydride and ketone. Then, the approach of the ketone to the metal-hydride complex could occur in two ways, involving the re-face or si-face of the ketone. Figure 2 illustrates the transition states in the case of (R,R)-pybox complexes, showing that the steric repulsions of the oxazoline-and ketone-phenyl groups make transition state A lower in energy than transition state B, providing the (S)-alcohols preferentially [19,32]. terms of both conversion and enantiomeric excess. Thus, although the reduction of 2methoxyacetophenone (entries 6 and 7) was rather inefficient, isobutyrophenone could be transformed into the alcohol with high enantiomeric excess and moderate (entry 8) or good conversion (entry 9). Complexes 1 and 2 fulfilled the requirement to be precursors of active species in the catalytic asymmetric transfer hydrogenation of ketones by hydrogen transfer from i PrOH/base. Regarding the stereochemical outcome, the observed results were in accordance with the established reaction pathway [28][29][30][31]. Thus, the hydrogen transfer step had been proposed to occur through a fourmembered cyclic transition state, involving the metal-hydride and the ketone. Such a transition state would result from i) chloride extraction and metal isopropoxide formation, ii) generation of metal hydride by β-elimination of propanone (an inner-sphere mechanism), iii) loss of the second chloride to generate a 16-electron metal hydride, iv) coordination of metal hydride and ketone. Then, the approach of the ketone to the metal-hydride complex could occur in two ways, involving the re-face or si-face of the ketone. Figure 2 illustrates the transition states in the case of (R,R)-pybox complexes, showing that the steric repulsions of the oxazoline-and ketone-phenyl groups make transition state A lower in energy than transition state B, providing the (S)-alcohols preferentially [19,32]. terms of both conversion and enantiomeric excess. Thus, although the reduction of 2methoxyacetophenone (entries 6 and 7) was rather inefficient, isobutyrophenone could be transformed into the alcohol with high enantiomeric excess and moderate (entry 8) or good conversion (entry 9). Complexes 1 and 2 fulfilled the requirement to be precursors of active species in the catalytic asymmetric transfer hydrogenation of ketones by hydrogen transfer from i PrOH/base. Regarding the stereochemical outcome, the observed results were in accordance with the established reaction pathway [28][29][30][31]. Thus, the hydrogen transfer step had been proposed to occur through a fourmembered cyclic transition state, involving the metal-hydride and the ketone. Such a transition state would result from i) chloride extraction and metal isopropoxide formation, ii) generation of metal hydride by β-elimination of propanone (an inner-sphere mechanism), iii) loss of the second chloride to generate a 16-electron metal hydride, iv) coordination of metal hydride and ketone. Then, the approach of the ketone to the metal-hydride complex could occur in two ways, involving the re-face or si-face of the ketone. Figure 2 illustrates the transition states in the case of (R,R)-pybox complexes, showing that the steric repulsions of the oxazoline-and ketone-phenyl groups make transition state A lower in energy than transition state B, providing the (S)-alcohols preferentially [19,32]. terms of both conversion and enantiomeric excess. Thus, although the reduction of 2methoxyacetophenone (entries 6 and 7) was rather inefficient, isobutyrophenone could be transformed into the alcohol with high enantiomeric excess and moderate (entry 8) or good conversion (entry 9). Complexes 1 and 2 fulfilled the requirement to be precursors of active species in the catalytic asymmetric transfer hydrogenation of ketones by hydrogen transfer from i PrOH/base. Regarding the stereochemical outcome, the observed results were in accordance with the established reaction pathway [28][29][30][31]. Thus, the hydrogen transfer step had been proposed to occur through a fourmembered cyclic transition state, involving the metal-hydride and the ketone. Such a transition state would result from i) chloride extraction and metal isopropoxide formation, ii) generation of metal hydride by β-elimination of propanone (an inner-sphere mechanism), iii) loss of the second chloride to generate a 16-electron metal hydride, iv) coordination of metal hydride and ketone. Then, the approach of the ketone to the metal-hydride complex could occur in two ways, involving the re-face or si-face of the ketone. Figure 2 illustrates the transition states in the case of (R,R)-pybox complexes, showing that the steric repulsions of the oxazoline-and ketone-phenyl groups make transition state A lower in energy than transition state B, providing the (S)-alcohols preferentially [19,32]. terms of both conversion and enantiomeric excess. Thus, although the reduction of 2methoxyacetophenone (entries 6 and 7) was rather inefficient, isobutyrophenone could be transformed into the alcohol with high enantiomeric excess and moderate (entry 8) or good conversion (entry 9). Complexes 1 and 2 fulfilled the requirement to be precursors of active species in the catalytic asymmetric transfer hydrogenation of ketones by hydrogen transfer from i PrOH/base. Regarding the stereochemical outcome, the observed results were in accordance with the established reaction pathway [28][29][30][31]. Thus, the hydrogen transfer step had been proposed to occur through a fourmembered cyclic transition state, involving the metal-hydride and the ketone. Such a transition state would result from i) chloride extraction and metal isopropoxide formation, ii) generation of metal hydride by β-elimination of propanone (an inner-sphere mechanism), iii) loss of the second chloride to generate a 16-electron metal hydride, iv) coordination of metal hydride and ketone. Then, the approach of the ketone to the metal-hydride complex could occur in two ways, involving the re-face or si-face of the ketone. Figure 2 illustrates the transition states in the case of (R,R)-pybox complexes, showing that the steric repulsions of the oxazoline-and ketone-phenyl groups make transition state A lower in energy than transition state B, providing the (S)-alcohols preferentially [19,32]. terms of both conversion and enantiomeric excess. Thus, although the reduction of 2methoxyacetophenone (entries 6 and 7) was rather inefficient, isobutyrophenone could be transformed into the alcohol with high enantiomeric excess and moderate (entry 8) or good conversion (entry 9). Complexes 1 and 2 fulfilled the requirement to be precursors of active species in the catalytic asymmetric transfer hydrogenation of ketones by hydrogen transfer from i PrOH/base. Regarding the stereochemical outcome, the observed results were in accordance with the established reaction pathway [28][29][30][31]. Thus, the hydrogen transfer step had been proposed to occur through a fourmembered cyclic transition state, involving the metal-hydride and the ketone. Such a transition state would result from i) chloride extraction and metal isopropoxide formation, ii) generation of metal hydride by β-elimination of propanone (an inner-sphere mechanism), iii) loss of the second chloride to generate a 16-electron metal hydride, iv) coordination of metal hydride and ketone. Then, the approach of the ketone to the metal-hydride complex could occur in two ways, involving the re-face or si-face of the ketone. Figure 2 illustrates the transition states in the case of (R,R)-pybox complexes, showing that the steric repulsions of the oxazoline-and ketone-phenyl groups make transition state A lower in energy than transition state B, providing the (S)-alcohols preferentially [19,32]. terms of both conversion and enantiomeric excess. Thus, although the reduction of 2methoxyacetophenone (entries 6 and 7) was rather inefficient, isobutyrophenone could be transformed into the alcohol with high enantiomeric excess and moderate (entry 8) or good conversion (entry 9). a Reactions were carried out at 82 °C using 5 mmol of ketone and 2-propanol (75 mL), 0.015 mmol (0.3 mol %) catalyst, and NaO t Bu (acetophenone/catalyst/NaO t Bu 500:1.5:12). b Calculated TOF (turnover frequency) values at t = 5 min. c Determined by GC with a Supelco β-DEX 120 chiral capillary column.
Complexes 1 and 2 fulfilled the requirement to be precursors of active species in the catalytic asymmetric transfer hydrogenation of ketones by hydrogen transfer from i PrOH/base. Regarding the stereochemical outcome, the observed results were in accordance with the established reaction pathway [28][29][30][31]. Thus, the hydrogen transfer step had been proposed to occur through a fourmembered cyclic transition state, involving the metal-hydride and the ketone. Such a transition state would result from i) chloride extraction and metal isopropoxide formation, ii) generation of metal hydride by β-elimination of propanone (an inner-sphere mechanism), iii) loss of the second chloride to generate a 16-electron metal hydride, iv) coordination of metal hydride and ketone. Then, the approach of the ketone to the metal-hydride complex could occur in two ways, involving the re-face or si-face of the ketone. Figure 2 illustrates the transition states in the case of (R,R)-pybox complexes, showing that the steric repulsions of the oxazoline-and ketone-phenyl groups make transition state A lower in energy than transition state B, providing the (S)-alcohols preferentially [19,32]. a Reactions were carried out at 82 • C using 5 mmol of ketone and 2-propanol (75 mL), 0.015 mmol (0.3 mol %) catalyst, and NaO t Bu (acetophenone/catalyst/NaO t Bu 500:1.5:12). b Calculated TOF (turnover frequency) values at t = 5 min. c Determined by GC with a Supelco β-DEX 120 chiral capillary column.
Complexes 1 and 2 fulfilled the requirement to be precursors of active species in the catalytic asymmetric transfer hydrogenation of ketones by hydrogen transfer from i PrOH/base. Regarding the stereochemical outcome, the observed results were in accordance with the established reaction pathway [28][29][30][31]. Thus, the hydrogen transfer step had been proposed to occur through a four-membered cyclic transition state, involving the metal-hydride and the ketone. Such a transition state would result from i) chloride extraction and metal isopropoxide formation, ii) generation of metal hydride by β-elimination of propanone (an inner-sphere mechanism), iii) loss of the second chloride to generate a 16-electron metal hydride, iv) coordination of metal hydride and ketone. Then, the approach of the ketone to the metal-hydride complex could occur in two ways, involving the re-face or si-face of the ketone. Figure 2 illustrates the transition states in the case of (R,R)-pybox complexes, showing that the steric repulsions of the oxazoline-and ketone-phenyl groups make transition state A lower in energy than transition state B, providing the (S)-alcohols preferentially [19,32]. Conversely, the use of (S,S)-pybox complexes favored the formation of the corresponding (R)-alcohols. Conversely, the use of (S,S)-pybox complexes favored the formation of the corresponding (R)alcohols.

X-Ray Crystal Structure Determination of Complexes 1a·2CHCl3 and 2c·2.5CH2Cl2
Suitable crystals for X-ray diffraction analysis were obtained by slow diffusion of n-hexane into a solution of the complexes in chloroform (1a) or dichloromethane (2c). The most relevant crystal and refinement data are collected in Table S2 in the Supporting Information.
The diffraction data of both complexes were recorded on an Oxford Diffraction Xcalibur Nova (Agilent, Santa Clara, CA, USA) single-crystal diffractometer, using Cu-Kα radiation (λ = 1.5418 Å). Images were collected at a 62 mm fixed crystal-detector distance, using the oscillation method, with 1° oscillation and variable exposure time per image (6.5-35 s (for 1a) and 30-110 s (for 2c)). The data collection strategy was calculated with the program CrysAlis Pro CCD [35]. Data reduction and cell refinement were performed with the program CrysAlis Pro RED [35]. Empirical absorption correction was applied using the SCALE3 ABSPACK algorithm, as implemented in the program CrysAlis Pro RED [35].
The software package WINGX [36] was used for space-group determination, structure solution, and refinement. The structures were solved by Patterson interpretation and phase expansion using DIRDIF [37]. In the crystals of 1a and 2c, 2CHCl3 (for 1a) or 2.5CH2Cl2 solvent molecules (for 2c) per unit formula of the complex were present. For complex 2c also, other highly disordered solvent molecules were found, which were impossible to refine using conventional discrete-atom models. To resolve these issues, the contribution of solvent electron density was removed by SQUEEZE/PLATON [38]. Isotropic least-squares refinement on F 2 using SHELXL2013 [39] was performed. During the final stages of the refinements, all the positional parameters and the anisotropic temperature factors of all the non-H atoms were refined. The H atoms were geometrically placed, riding on their parent atoms with isotropic displacement parameters set to 1.2 times the Ueq of the atoms to which they were attached (1.5 for methyl groups). For both complexes, the maximum residual electron density was located near heavy atoms.

X-ray Crystal Structure Determination of Complexes 1a·2CHCl 3 and 2c·2.5CH 2 Cl 2
Suitable crystals for X-ray diffraction analysis were obtained by slow diffusion of n-hexane into a solution of the complexes in chloroform (1a) or dichloromethane (2c). The most relevant crystal and refinement data are collected in Table S2 in the Supporting Information.
The diffraction data of both complexes were recorded on an Oxford Diffraction Xcalibur Nova (Agilent, Santa Clara, CA, USA) single-crystal diffractometer, using Cu-Kα radiation (λ = 1.5418 Å). Images were collected at a 62 mm fixed crystal-detector distance, using the oscillation method, with 1 • oscillation and variable exposure time per image (6.5-35 s (for 1a) and 30-110 s (for 2c)). The data collection strategy was calculated with the program CrysAlis Pro CCD [35]. Data reduction and cell refinement were performed with the program CrysAlis Pro RED [35]. Empirical absorption correction was applied using the SCALE3 ABSPACK algorithm, as implemented in the program CrysAlis Pro RED [35].
The software package WINGX [36] was used for space-group determination, structure solution, and refinement. The structures were solved by Patterson interpretation and phase expansion using DIRDIF [37]. In the crystals of 1a and 2c, 2CHCl 3 (for 1a) or 2.5CH 2 Cl 2 solvent molecules (for 2c) per unit formula of the complex were present. For complex 2c also, other highly disordered solvent molecules were found, which were impossible to refine using conventional discrete-atom models. To resolve these issues, the contribution of solvent electron density was removed by SQUEEZE/PLATON [38]. Isotropic least-squares refinement on F 2 using SHELXL2013 [39] was performed. During the final stages of the refinements, all the positional parameters and the anisotropic temperature factors of all the non-H atoms were refined. The H atoms were geometrically placed, riding on their parent atoms with isotropic displacement parameters set to 1.2 times the Ueq of the atoms to which they were attached (1.5 for methyl groups). For both complexes, the maximum residual electron density was located near heavy atoms.

General Procedure for Hydrogen Transfer Reactions
The ruthenium catalyst precursor 1, 2 (0.01 mmol) was placed in a three-bottomed Schlenk flask containing 5 mmol of ketone in 45 mL of 2-propanol under an argon atmosphere. The solution was heated at 82 • C for 15 min, and then a solution of 0.24 mmol of the base in 5 mL of 2-propanol was added, and the reaction mixture stirred for the time given in Tables 1-3. The course of the reaction was monitored by gas chromatography using a chromatography Agilent Model HP-6890 equipped with a Supelco β-DEX 120 chiral capillary column. The enantiomeric ratio and the absolute configuration of the major enantiomer were determined by GC (retention times) and optical rotations, respectively, and compared with literature values. The resulting alcohols and the starting ketones were, in all cases, the only products detected.

Conclusions
The present study showed that complexes featuring the combination Ru(II)/R-pybox [(S,S)-i Prpybox, (R,R)-Ph-pybox]/P-donor ligand (methoxy-phosphonites and methoxy-and ethoxy-phosphinites) were active catalysts toward the ATH reaction of arylketones. The best results were obtained using the complex trans-[RuCl 2 {PPh 2 (OEt)}{(R,R)-Ph-pybox}] (2c), providing (S)-benzylalcohols in high yield (87%-98 %) and enantioselectivity (up to 96 % e.e.). These results were in the range of those previously described using the complexes cisand trans-[RuCl 2 (L) {(R,R)-Ph-pybox}] (L = PPh 3 , P i Pr 3 ) and were superior to those obtained using the complexes with phosphite ligands trans-[RuCl 2 (L){(R,R)-Ph-pybox}] (L= P(OMe) 3 , P(OPh) 3 )). On the other hand, they confirmed that the nature of the achiral P-donor ligand did influence the efficiency of the catalyst. The values of asymmetric induction obtained were in accordance with the Tolman electronic parameter (cm −1 ) and the cone angles (deg) of these achiral ligands. Moreover, this report illustrated the utility of chiral ligands, lacking the N-H functionality, thus complementing previous works of ATH processes based on chiral N-H ligands.