Study of the Influence of the Change from Methyl to Isopropyl Substituents in 1-(2,4,6-trialkylphenyl)ethanol on the Point Group Symmetry of the 0-D Hydrogen-Bonded Moiety

: The steric hindrance in molecules of 1-(2,4,6-trimethylphenyl)ethanone and 1-(2,4,6-triisopropylphenyl)ethanone were shown to substantially differentiate the options of synthesis of the respective alcohols. The former was obtained with a yield of 12% with a mild reducing agent, i.e., NaBH 4 , as well as in vapor phase transfer hydrogenation (22% yield at 673 K) over MgO, whereas the latter was not formed at all under those conditions. The only agent that was able to reduce both ketones was LiAlH 4 . The single crystals of the two alcohols were obtained and their structures were determined. The symmetry of the 0-D hydrogen-bonded networks of molecules in these crystals was analyzed. It was shown that the methyl substituent allows the molecules to form hexameric rings, whereas the isopropyl-substituted molecules formed tetrameric ones. In both cases, there were two types of rings in the cell, but four types of molecules forming tetramers and only three types of molecules in the hexamers. These structures were compared to similar structures formed by other molecules found in the Cambridge Structural Database via hydrogen bonding. Moreover, the single crystal of 1-(2,4,6-triisopropylphenyl)ethanone was obtained to explain if either the hydrogen bonding or the presence of isopropyl groups influences the angles in the molecules.


Introduction
There are several classical methods of reducing ketones and aldehydes to alcohols which are commonly used, each with its set of benefits and drawbacks.One of the basic methods is the application of gaseous hydrogen in the presence of catalysts [1][2][3][4]: heterogeneous metallic ones or homogeneous ones in the form of organometallic complexes.The reducing agent is cheap and hence is favored in large-scale set-ups.The most active metals among the studied ones are platinum, palladium, rhodium and nickel, especially the highly active form obtained by leaching an aluminum-nickel alloy, called Raney nickel.Raney nickel has been implemented in the industrial process of reduction of dextrose [5][6][7] and furfural [8,9].On a smaller scale, in the case of pharmaceuticals sodium borohydride is often used as the reducing agent because it allows for highly selective reduction of carbonyl groups [10,11].In comparison, lithium aluminum hydride exhibits a much higher reactivity than NaBH 4 , but it requires the use of non-polar solvents, such as aliphatic ethers, pyridine and tetrahydrofuran [12].
It is commonly known that both the number and position of substituents in organic molecules such as alcohols, ketones and carboxylic acids determine their reactivity.This has also been observed in heterogeneous catalysis in reactions, including catalytic transfer hydrogenation (CTH) and ketonization [13][14][15][16][17].The dependence between the structure and reactivity is discussed in a previously published paper [18].The effect of the number and location of substituents was shown with the three monosubstituted acetophenones with the methyl group in the ortho, meta and para position, and different disubstituted Crystals 2024, 14, 642 2 of 17 acetophenones [19].Steric hindrances in the molecules can be equally influential, as shown by the example of 2,2,4,4-tetramethyl-3-pentanone, which is completely inactive in this reaction [18].In contrast, the molecule of 1-phenyl-2,2-dimethylpropan-1-one is very highly reactive despite the bulky t-butyl group [19] due to torsional strain in the carbonyl region and hence is easily reduced to the alcohol.
In molecular crystals, both the geometry, including torsion angles, and the formation of hydrogen bonds can give valuable information regarding the potential reactivity of a reagent.The pronounced differences in the behavior of two similar ketones in catalytic transfer hydrogenation, namely 1-(2,4,6-trimethylphenyl)ethanone and 1-(2,4,6triisopropylphenyl)ethanone, which differ from one another only by the size of the substituent [19], have led us to consider different methods of synthesis of these alcohols, such as reduction of the ketone with Raney nickel, sodium borohydride, lithium aluminum hydride, etc.Some options have been reported in the literature [20,21].The differences in the reactivity have led us to investigate the molecular crystals formed by these two compounds.This paper aims to investigate the differences in the geometry of the molecules of two alcohols and the influence of the geometry on the formation of hydrogen-bonded networks.Furthermore, the study is meant to determine if the hydrogen bonding itself influences the molecule geometry.For this purpose, the geometry and weak hydrogen-bonds in the corresponding ketone were also analyzed.
The formation of 0-D structures, such as dimers, trimers, etc. via formation of O-H. ..O type hydrogen bonds in the molecular crystals of alcohols is expected and wellstudied [22,23].A description of possible aggregate patterns is provided by Grabowski [24] and Etter, e.g., in [25], who studied the influence of the hydrogen bonding on the properties of organic compounds.Depending on the geometry of the molecule, number and type of donor/acceptor atoms, any of the following networks can develop: 0-D, such as the trimer and tetramer shown in Figure 1a, a dimer that can produce 1-D structures thanks to weaker C-H. ..O bonds (Figure 1b) or a 2-D structure connected solely via strong O-H. ..O type hydrogen bonds, provided that there are at least two OH groups in the molecule (Figure 1c), etc.
Crystals 2024, 14, x FOR PEER REVIEW 2 of 17 with the methyl group in the ortho, meta and para position, and different disubstituted acetophenones [19].Steric hindrances in the molecules can be equally influential, as shown by the example of 2,2,4,4-tetramethyl-3-pentanone, which is completely inactive in this reaction [18].In contrast, the molecule of 1-phenyl-2,2-dimethylpropan-1-one is very highly reactive despite the bulky t-butyl group [19] due to torsional strain in the carbonyl region and hence is easily reduced to the alcohol.In molecular crystals, both the geometry, including torsion angles, and the formation of hydrogen bonds can give valuable information regarding the potential reactivity of a reagent.The pronounced differences in the behavior of two similar ketones in catalytic transfer hydrogenation, namely 1-(2,4,6-trimethylphenyl)ethanone and 1-(2,4,6-triisopropylphenyl)ethanone, which differ from one another only by the size of the substituent [19], have led us to consider different methods of synthesis of these alcohols, such as reduction of the ketone with Raney nickel, sodium borohydride, lithium aluminum hydride, etc.Some options have been reported in the literature [20,21].The differences in the reactivity have led us to investigate the molecular crystals formed by these two compounds.This paper aims to investigate the differences in the geometry of the molecules of two alcohols and the influence of the geometry on the formation of hydrogen-bonded networks.Furthermore, the study is meant to determine if the hydrogen bonding itself influences the molecule geometry.For this purpose, the geometry and weak hydrogen-bonds in the corresponding ketone were also analyzed.
The formation of 0-D structures, such as dimers, trimers, etc. via formation of O-H…O type hydrogen bonds in the molecular crystals of alcohols is expected and wellstudied [22,23].A description of possible aggregate patterns is provided by Grabowski [24] and Etter, e.g., in [25], who studied the influence of the hydrogen bonding on the properties of organic compounds.Depending on the geometry of the molecule, number and type of donor/acceptor atoms, any of the following networks can develop: 0-D, such as the trimer and tetramer shown in Figure 1a, a dimer that can produce 1-D structures thanks to weaker C-H…O bonds (Figure 1b) or a 2-D structure connected solely via strong O-H…O type hydrogen bonds, provided that there are at least two OH groups in the molecule (Figure 1c), etc.Although in crystallography, point groups are commonly applied to define the crystal class, point groups serve well to indicate the symmetrical relations of the repeating units in discrete oligomers.As such, point groups can be used to describe the symmetry of hydrogen bonds of organic molecules such as monocarboxylic acids [26,27].The symmetry relations and the number of molecules in an oligomer depend on the geometry of the molecules, which impact their ability to develop into higher order networks, and as a consequence, their reactivity.The simplest assembly of molecules is a dimer, which is easily formed by organic acids, in which one oxygen atom of the carboxylic group acts as a hydrogen donor and the other as an acceptor.Several derivatives of benzoic acid can be found in the Cambridge Structural Database (CSD) [28].The REFCODE, i.e., unique symbol consisting of six letters and optionally a number under which a given compound is listed in the CSD, is provided in the text.Figure 2a,b depict the O-H. ..O dimers formed by molecules of benzoic acid (BENZAC01, [26]) and 2,4,6-trimethylbenzoic acid (TMBZAC02, [29]), respectively.In the unsubstituted molecule, the angle formed by the plane of the carboxyl group (χ) with the plane of the ring (φ) is only 1.5 • .In contrast, in the case of 2,4,6-trimethylbenzoic acid, this angle is 42.7 • .Despite this difference in the geometry of the dimer, both types of dimers form weaker hydrogen bonds, i.e., C-H. ..O ones, to form 1-D networks with the p1 rod group symmetry (Figure 2c,d).The chains run in direction [1 1 0] and [0 1 0] with a translation vector of 7.55 Å and 7.04 Å, respectively.Although in crystallography, point groups are commonly applied to define the crystal class, point groups serve well to indicate the symmetrical relations of the repeating units in discrete oligomers.As such, point groups can be used to describe the symmetry of hydrogen bonds of organic molecules such as monocarboxylic acids [26,27].The symmetry relations and the number of molecules in an oligomer depend on the geometry of the molecules, which impact their ability to develop into higher order networks, and as a consequence, their reactivity.The simplest assembly of molecules is a dimer, which is easily formed by organic acids, in which one oxygen atom of the carboxylic group acts as a hydrogen donor and the other as an acceptor.Several derivatives of benzoic acid can be found in the Cambridge Structural Database (CSD) [28].The REFCODE, i.e., unique symbol consisting of six letters and optionally a number under which a given compound is listed in the CSD, is provided in the text.Figure 2a,b depict the O-H…O dimers formed by molecules of benzoic acid (BENZAC01, [26]) and 2,4,6-trimethylbenzoic acid (TMBZAC02, [29]), respectively.In the unsubstituted molecule, the angle formed by the plane of the carboxyl group (χ) with the plane of the ring (φ) is only 1.5°.In contrast, in the case of 2,4,6-trimethylbenzoic acid, this angle is 42.7°.Despite this difference in the geometry of the dimer, both types of dimers form weaker hydrogen bonds, i.e., C-H…O ones, to form 1-D networks with the p1 rod group symmetry (Figure 2c,d).The chains run in direction [1 1 0] and [0 1 0] with a translation vector of 7.55 Å and 7.04 Å, respectively.It is noteworthy that among different benzoic acid derivatives, all of which form dimers, there are different possibilities of expanding a 0-D network into higher dimensional networks.Dimers of 2,3,4,5,6-pentamethyl benzoic acid (TUSQIH, [30]) can be seen in Figure 3.The angles formed by the plane of the carboxyl group (χ) with the plane of the ring (φ) in the two independent molecules are 87.9 and 89.1°.These dimers develop into tetramers (Figure 3b), which further expand via weaker hydrogen bonds, the C-H…O type bonds, to form a chain along [0 1 0] (Figure 3c).The existence of this type of hydrogen bond was first acknowledged by Sutor [31] in 1962.Since then, a lot of information regarding these types of interactions has been gained in terms of their lengths, angles formed, as well as techniques used to investigate such bonds [32][33][34][35][36].In the case of molecules of It is noteworthy that among different benzoic acid derivatives, all of which form dimers, there are different possibilities of expanding a 0-D network into higher dimensional networks.Dimers of 2,3,4,5,6-pentamethyl benzoic acid (TUSQIH, [30]) can be seen in Figure 3.The angles formed by the plane of the carboxyl group (χ) with the plane of the ring (φ) in the two independent molecules are 87.9 and 89.1 • .These dimers develop into tetramers (Figure 3b), which further expand via weaker hydrogen bonds, the C-H. ..O type bonds, to form a chain along [0 1 0] (Figure 3c).The existence of this type of hydrogen bond was first acknowledged by Sutor [31] in 1962.Since then, a lot of information regarding these types of interactions has been gained in terms of their lengths, angles formed, as well as techniques used to investigate such bonds [32][33][34][35][36].In the case of molecules of compounds that do not contain O-H groups, i.e., ketones, only C-H. ..O bonds can lead to the formation of hydrogen-bonded networks.
compounds that do not contain O-H groups, i.e., ketones, only C-H…O bonds can lead to the formation of hydrogen-bonded networks.The development of a 0-D network into higher dimensions via hydrogen bonding can also be hindered by the geometry of the molecule itself.For example, the molecules of 2,4-dimethylbenzoic acid (synthesized by us earlier and described in [27]) are not flat.The plane of the aromatic ring and the plane of the carboxyl group form an angle of 14.1°.As a result, dimers of these molecules (Figure 4a) do not form rod groups nor combine into larger clusters.Their arrangement in the unit cell is depicted in Figure 4b.This shows that both the number of the substituents and the geometry of the molecule itself determine the options of development of dimers into larger hydrogen-bonded networks.

Reagents
Aluminum chloride (98.5%, anhydrous powder, extra pure), aluminum isopropoxide (98%), sodium borohydride (98+%, VenPure, A.F. granules) and lithium aluminum hydride (95% reagent grade, pellets), all from Aldrich (Poznań, Poland) were used as received.The solution/suspension of NaBH4, LiAlH4 and AlCl3 were prepared directly prior to their use and were used in excess.After the allotted reaction time, the presence of The development of a 0-D network into higher dimensions via hydrogen bonding can also be hindered by the geometry of the molecule itself.For example, the molecules of 2,4-dimethylbenzoic acid (synthesized by us earlier and described in [27]) are not flat.The plane of the aromatic ring and the plane of the carboxyl group form an angle of 14.1 • .As a result, dimers of these molecules (Figure 4a) do not form rod groups nor combine into larger clusters.Their arrangement in the unit cell is depicted in Figure 4b.This shows that both the number of the substituents and the geometry of the molecule itself determine the options of development of dimers into larger hydrogen-bonded networks.
compounds that do not contain O-H groups, i.e., ketones, only C-H…O bonds can lead to the formation of hydrogen-bonded networks.The development of a 0-D network into higher dimensions via hydrogen bonding can also be hindered by the geometry of the molecule itself.For example, the molecules of 2,4-dimethylbenzoic acid (synthesized by us earlier and described in [27]) are not flat.The plane of the aromatic ring and the plane of the carboxyl group form an angle of 14.1°.As a result, dimers of these molecules (Figure 4a) do not form rod groups nor combine into larger clusters.Their arrangement in the unit cell is depicted in Figure 4b.This shows that both the number of the substituents and the geometry of the molecule itself determine the options of development of dimers into larger hydrogen-bonded networks.

Reagents
Aluminum chloride (98.5%, anhydrous powder, extra pure), aluminum isopropoxide (98%), sodium borohydride (98+%, VenPure, A.F. granules) and lithium aluminum hydride (95% reagent grade, pellets), all from Aldrich (Pozna ń, Poland) were used as received.The solution/suspension of NaBH 4 , LiAlH 4 and AlCl 3 were prepared directly prior to their use and were used in excess.After the allotted reaction time, the presence of NaBH 4 and LiAlH 4 in the post-reaction mixture was checked: for this purpose, 0.3 cm 3 of the solution was taken and 1-2 drops of a 20% acetic acid solution were added.The intense evolution of hydrogen clearly indicated the presence of an excess of the reducing agent in the solution.
To produce Raney nickel catalyst, a solution of 30.0 g of KOH (pure, POCh, Gliwice, Poland) in 300 cm 3 of redistilled water was poured into a 500 cm 3 beaker.The solution was cooled to 278 K and, while stirring, 20.0 g of powdered NiAl alloy (pure, nickel-aluminum catalyst alloy 50/50, Koch Light Lab., Haverhill, UK) was poured in small portions so that the temperature did not exceed 298 K. Next, it was stirred for 4 h and the solution was decanted from the precipitate.The precipitate was washed with 20 portions (20 × 50 cm 3 ) of redistilled water until the solution was neutral.Then, the precipitate was washed with three portions (3 × 30 cm 3 ) of 96% ethanol and three portions (3 × 30 cm 3 ) of anhydrous ethanol.The resulting Raney nickel precipitate was stored for a short time (20 h) over anhydrous ethanol.
The purity of organic reagents was analyzed by gas chromatography with a HRGC 4000B KONIK instrument (Barcelona, Spain).A 30 m long TRACER WAX capillary column (i.d.0.25 µm) and a flame ionization detector were used for the determination of purity.The compounds were identified by GC-MS (HP-6890N with a 5973N mass detector) (Agilent, Santa Clara, CA, USA).Solids were dissolved in hexane prior to GC analysis.The final products (alcohols) and their parent ketones were tested with Attenuated Total Reflectance (ATR) Fourier Transform Infra-Red (FTIR) spectroscopy.The spectra were obtained on a Nicolet iS5 spectrometer (ThermoFisher Scientific, Dreieich, Germany) in the range: 500-4000 cm −1 .

Synthesis
All syntheses were carried out under ambient air atmosphere.

Synthesis of 1-(2,4,6-trimethylphenyl)ethanol
(1) Reduction of the ketone with Raney nickel: 3.0 g of Raney nickel was mixed with 20 cm 3 of ethanol and 15.0 g of the ketone, 1-(2,4,6-trmethylphenyl)ethanone.A home-made autoclave, built at the Institute of Physical Chemistry Polish Academy of Sciences, volume 300 cm 3 , maximum pressure 35 MPa at 523 K, was closed and pressurized with hydrogen to 13 MPa.It was heated to 363 K, which increased the overall pressure to 15 MPa.After 15 h, the yield was 54%.
(2) Reduction of the ketone with sodium borohydride [38]: The solution of 0.53 g (0.014 mol) of sodium borohydride in water (15 cm 3 ) containing a small amount of sodium hydroxide (pH adjustment to avoid NaBH 4 decomposition) was prepared directly prior to use.It was added dropwise to a stirred solution of 4.86 g (0.03 mol) of the ketone in ethanol (50 cm 3 ) at 323 K over approximately 15 min.Next, the temperature was maintained for another 45 min.The reaction mixture was cooled.After dilution with water, the product was extracted with n-hexane.Chromatographic analysis showed that the reduction occurred with a yield of only 12%.
(3) Reduction of the ketone via the Meerwein-Ponndorf-Verley method [39]: To a solution of 4.08 g (0.02 mol) of aluminum isopropoxide in 50 cm 3 of isopropyl alcohol a solution of 4.86 g (0.03 mol) of 2,4,6-trimethylacetophenone in 50 cm 3 of isopropyl alcohol was added.The mixture was held at approximately 353 K for two hours and distilled slowly.Due to the absence of acetone (the second reaction product) in the distillate, the reaction mixture was heated for another 12 h.GC analysis showed that the reaction did not occur.
(4) Reduction of the ketone with lithium aluminum hydride: A diethyl ether solution of the ketone (8.1 g, 0.050 mol) was slowly added to a freshly prepared suspension of 1.173 g (0.031 mol) of LiAlH 4 in 30 cm 3 of diethyl ether maintained at 273 K with constant stirring.The reaction mixture was kept at reflux for two hours.Then, the mixture was hydrolyzed using 7.2 cm 3 of water and 5.9 cm 3 of 10% NaOH.The product was extracted with n-hexane and dried over anhydrous magnesium sulfate.The solvents were then evaporated and 5.5 g of a colorless solid were obtained (yield: 67%), m.p. 344-5 K (exp.), 345.2-345.7 K (lit.)[39], ATR-FTIR 3229, 3192, 2966, 2897, 2841, 2710 cm −1 .

Synthesis of 1-(2,4,6-triisopropylphenyl)ethanol
(1) Reduction of the ketone with sodium borohydride: The procedure was analogous to that described in Section 2.2.1 starting with 4.92 g (0.02 mol) of the ketone in ethanol.After the solution of the reducing agent was added, the reaction mixture was stirred for 2 days at room temperature.The reduction did not occur.
(2) Reduction of the ketone with sodium borohydride at elevated temperature: To a stirred solution of 4.92 g (0.02 mol) of the ketone in 2-propanol (30 cm 3 ) kept at 343 K, a freshly prepared solution of 0.53 g (0.014 mol) of sodium borohydride in water (15 cm 3 ) containing a small amount of sodium hydroxide was slowly added.The reduction did not occur.
(3) Reduction of the ketone via the Meerwein-Ponndorf-Verley method: To a stirred solution of 7.7 g (0.037 mol) of aluminum isopropoxide in 2-propanol (60 cm 3 ) a solution of 12.3 g (0.05 mol) of the ketone in 2-propanol (100 cm 3 ) was added.A slow distillation through a 50 cm long column filled with Fenske helices for 10 h yielded no acetone (the reduction did not occur).
(4) Reduction of the ketone with Raney nickel: the procedure was analogous to that described in Section 2.2.1, starting with 3.0 g of Raney nickel in 20 cm 3 of ethanol and 4.92 g (0.02 mol) of the ketone, which were placed in an autoclave, closed and pressurized with hydrogen to 11 MPa.The reaction mixture was then heated to T = 403 K for 6 h, which resulted in a final pressure of 15 MPa.The reduction did not occur.

Synthesis of 1-(2,4,6-triisopropylphenyl)ethanone
In a 350 cm 3 reactor, acetyl chloride (4.0 g, 0.05 mol) was poured in one portion into a freshly prepared suspension of AlCl 3 (8.0g, 0.06 mol) in 50 cm 3 CH 2 Cl 2 -a color change from yellow to orange was noted.1,3,5-Triisopropylbenzene (10.2 g, 0.05 mol) was slowly added to the formed complex, maintaining the temperature below 293 K.After the hydrocarbon was added, the contents of the reactor were heated in a water bath and the mixture was kept at reflux for one hour.Then, hydrolysis was carried out with 140 cm 3 of dilute hydrochloric acid (1:1).The organic layer was washed with water, followed by an aqueous NaHCO 3 solution and dried over anhydrous MgSO 4 .The solvent was evaporated and the obtained pink solid was dissolved in 10 cm 3 of n-hexane.Activated carbon was added to the liquid and the mixture was brought to boiling.The colorless solution was cooled and filtered under reduced pressure.The ketone was obtained with 52% yield (6.4 g, 0.026 mol) as a colorless solid, m.p. 357-8 K (exp.), 360 K (lit.)[39], ATR-FTIR 3047, 2959, 2929, 2867, 1692, 1456, 1360, 1237 cm −1 .

Single Crystal Preparation
After the synthesis and purification of each of the compounds listed above, attempts were made to obtain single crystals (under ambient air atmosphere) suitable for diffraction measurements.A single crystal was needed that had no inclusions, cracks, or any other visible structural defects.Two methods of growing single crystals were used: (1) Crystallization from solution [40]: approximately 0.3 g of the substance was placed in a 25 cm 3 conical flask and dissolved in 5 cm 3 of n-hexane.The flask was then closed with a layer of tissue paper so that the solvent could slowly escape from it; (2) Cooling of a solution of known concentration [41]: solutions of various concentrations were prepared in conical flasks (25 cm 3 ) at 323 K, and then the temperature of the flask was lowered to approximately room temperature.

Crystallization of 1-(2,4,6-trimethylphenyl)ethanol
The crystals obtained by method 1 and method 2 from n-hexane contained molecules of the solvent and became opaque in time.During the measurement, the crystals gradually disintegrated as the n-hexane molecules trapped in the crystal escaped from it.
The crystal obtained by method 2 from toluene was covered with glue and stuck onto a capillary.The measurement on a SIEMENS P3 diffractometer (SIEMENS, Munich, Germany) was started.The crystal did not give any reflections-it had probably reacted with the glue.The next crystal was selected and closed in a Lindeman glass capillary (Φ = 0.7 mm).The measurement was performed on a KUMA CCD diffractometer (KUMA Diffraction, Wrocław, Poland).

Crystallization of 1-(2,4,6-triisopropylphenyl)ethanol
The crystal was obtained by crystallization using method 1 from n-hexane and glued onto a capillary, and then it was measured on a KUMA CCD diffractometer.

Crystallization of 1-(2,4,6-triisopropylphenyl)ethanone
Two types of crystal shapes were obtained from n-hexane using method 1: needles and plates.A needle-like crystal was stuck onto a capillary and measurement with a SIEMENS P3 diffractometer.The crystal did not give any reflections.Next, the plate-shaped crystal was glued to a capillary and measured on a SIEMENS P3 diffractometer.

Single Crystal Diffraction Measurements and Structure Refinement
The diffraction measurements of all compounds were conducted using Mo-Kα radiation with a wavelength of 0.71073 Å monochromatized by a graphite monochromator.Measurements were performed on a four-circle SIEMENS P3 diffractometer at a temperature of 293 K or on a KUMA CCD diffractometer with a low-temperature attachment at a temperature of 173 K. Once the unit cell parameters were determined, the appropriate number of reflections for a given crystallographic system was collected, and data reduction was performed using a program appropriate for the diffractometer on which the measurement was performed.The structures were resolved with SHELXS-97 software [42] using direct methods.As a result of resolving the structure, an approximate model was obtained, which was then refined using a full-matrix refinement using the least squares method with SHELXL-97, as described below.Finally, drawings of molecules and structures were made with either ORTEP-III [43] or Diamond v. 3.2f [44] software.Diamond was also used to prepare the images of compounds from the Cambridge Structural Database (CSD) [28].

Refinement of 1-(2,4,6-trimethylphenyl)ethanol Molecules
After refining the position of carbon and oxygen atoms and the isotropic temperature factors of these atoms, anisotropic temperature factors were introduced into the model in all independent molecules of 1-(2,4,6-trimethylphenyl)ethanol, electron density maxima were observed in the differential electron density map in the region of -CH(OH)CH 3 groups.The disorder found in the R enantiomer was also present in the S enantiomer of a given molecule, and was modeled and refined isotropically.All three independent molecules of the alcohol had constraints imposing appropriate geometry on the -CH(OH)CH 3 groups.Then, anisotropic temperature factors were introduced into the model, with the restriction that these factors were the same for the corresponding atoms of the -CH(OH)CH 3 groups.The final occupancy ratios for the two options of the modeled disorder were 0.820 and 0.180, respectively.Hydrogen atoms were then introduced at the calculated positions, and their shifts were refined based on the shifts of the carbon atoms to which they were bonded.

Refinement of 1-(2,4,6-triisopropylphenyl)ethanol Molecules
After correcting for anisotropic temperature factors, hydrogen atoms were introduced into the four independent molecules of 1-(2,4,6-triisopropylphenyl)ethanol in the calculated positions based on the positions of the carbon atoms to which they were bonded.In all molecules of this alcohol, electron density maxima were observed in the Fourier map in the region of -CH(OH)CH 3 groups.
Crystal Data for C

Results
The reduction of 1-(2,4,6-trimethylphenyl)ethanone and 1-(2,4,6-triisopropylphe-nyl) ethanone was performed with a series of reductants, such as sodium borohydride, lithium aluminum hydride, hydrogen in the presence of Raney nickel, as well as 2-propanol in the presence of aluminum alkoxide.Each of these reducing agents had a different reducing potential, which was observed in the case of the former.In contrast, the only successful method of the synthesis of the 1-(2,4,6-triisopropylphenyl)ethanol was using lithium aluminum hydride.Catalytic transfer hydrogenation using 2-propanol as the hydrogen donor, used in 3:1 excess, in the presence of MgO as the catalyst, a yield of 22% was obtained at 673 K.This is noteworthy considering the fact that the alcohol yield using gaseous hydrogen with Raney nickel was 54%.In the case of the ketone with the bulky isopropyl group, the reaction with the hydrogen donor did not occur.
1-(2,4,6-Trimethylphenyl)ethanol crystallizes in the trigonal system in the P3 Space Group.The unit cell contains three independent molecules, which are shown in Figure 5a.The numbering scheme is shown on the first molecule (Figure 5a).The lengths of C2-C9 and C6-C11 bonds in the molecules of 1-(2,4,6-trimethylphenyl)ethanol range from 1.503 to 1.530 Ǻ, while in the compounds from the database, the range of observed values of these bonds is much narrower (1.512-1.516Ǻ).The values of the angles C(1)-C(2)-C(9) and C(1)-C(6)-C( 11) in all molecules are 123 • and are 2-3 • larger than the angles that form the substituents of the methyl group in the para position.There are two types of hexamers in the unit cell: Hexamer #1 with only type A molecules, and Hexamer #2 with three type B and three type C molecules which alternate (Figure 5b).Hexamer #1 occupies the corner sites in the crystal lattice, whereas Hexamer #2 is located along the main diagonal of the unit cell.
only successful method of the synthesis of the 1-(2,4,6-triisopropylphenyl)ethanol was using lithium aluminum hydride.Catalytic transfer hydrogenation using 2-propanol as the hydrogen donor, used in 3:1 excess, in the presence of MgO as the catalyst, a yield of 22% was obtained at 673 K.This is noteworthy considering the fact that the alcohol yield using gaseous hydrogen with Raney nickel was 54%.In the case of the ketone with the bulky isopropyl group, the reaction with the hydrogen donor did not occur.
1-(2,4,6-Trimethylphenyl)ethanol crystallizes in the trigonal system in the 3 P Space Group.The unit cell contains three independent molecules, which are shown in Figure 5a.The numbering scheme is shown on the first molecule (Figure 5a).The lengths of C2-C9 and C6-C11 bonds in the molecules of 1-(2,4,6-trimethylphenyl)ethanol range from 1.503 to 1.530 Ǻ, while in the compounds from the database, the range of observed values of these bonds is much narrower (1.512-1.516Ǻ).The values of the angles C(1)-C(2)-C(9) and C(1)-C(6)-C( 11) in all molecules are 123° and are 2-3° larger than the angles that form the substituents of the methyl group in the para position.There are two types of hexamers in the unit cell: Hexamer #1 with only type A molecules, and Hexamer #2 with three type B and three type C molecules which alternate (Figure 5b).Hexamer #1 occupies the corner sites in the crystal lattice, whereas Hexamer #2 is located along the main diagonal of the unit cell.In order to compare the hexamers of 1-(2,4,6-trimethylphenyl)ethanol to other hexamers formed by O-H...O hydrogen bonds, a systematic review of the Cambridge Structural Database was performed.Several structures were found to form this type of supramolecular structure.For example, there are two which crystallize in the P1 Space Group (3,4dimethylphenol, DPHNOL10 [45] and tricyclodecan-2-ol, SEYDEF [46]), two other molecules form hexamers in crystals with the R3m group (namely 2-isopropyl-5-methylphenol IP-MEPL [47], 1-(2-hydroxy-2-propyl)pyrene QEBBII [48]), and two in the P3 group (2-methyl-2-propanol: VATSAK01 [49] and VATSAK02 [49]).The hexamers formed by the molecules of all these compounds have a chair conformation.For simplification, only the hydrogen bonds of 1-(2,4,6-trimethylphenyl)ethanol and those in the hexamers of the three most similar structures to the one studied are presented in Figure 6.It is noteworthy that crystals of 2-methyl-2-propanol also have three independent molecules which arrange themselves in the same way as those of 1-(2,4,6-trimethylphenyl)ethanol.
Group (3,4-dimethylphenol, DPHNOL10 [45] and tricyclodecan-2-ol, SEYDEF [46]), two other molecules form hexamers in crystals with the 3 R m group (namely 2-isopropyl-5- methylphenol IPMEPL [47], 1-(2-hydroxy-2-propyl)pyrene QEBBII [48]), and two in the 3 P group (2-methyl-2-propanol: VATSAK01 [49] and VATSAK02 [49]).The hexamers formed by the molecules of all these compounds have a chair conformation.For simplification, only the hydrogen bonds of 1-(2,4,6-trimethylphenyl)ethanol and those in the hexamers of the three most similar structures to the one studied are presented in Figure 6.It is noteworthy that crystals of 2-methyl-2-propanol also have three independent molecules which arrange themselves in the same way as those of 1-(2,4,6-trimethylphenyl)ethanol.resulting tetramer is shown in Figure 7b.It can be seen that the centrosymmetric tetramers exhibit an S-S-R-R configuration.resulting tetramer is shown in Figure 7b.It can be seen that the centrosymmetric tetramers exhibit an S-S-R-R configuration.In order to investigate whether the changes in the geometric parameters resulting from the presence of a bulky group at the C(7) atom instead of a methyl group in the alcohol are due to the change of substituent or the OH. ..O hydrogen bonds formed, the ketone was crystallized and the structure was analyzed.In the obtained single crystal, the molecules of 1-(2,4,6-triisopropylphenyl)ethanone crystallize in the monoclinic system in the P2 1 /n Space Group.The same was found by Blair et al. [50].It can be seen in Figure 9 that the unsubstituted ketone, acetophenone (ACETPH, structural data from [51]), forms hydrogen-bonded networks via C-H. ..O bonds.This ketone is very similar to those reduced in this study, except that it lacks substituents.Therefore, it can serve as a baseline for the comparison with a similar molecule with bulky isopropyl substituents.In the crystal of acetophenone, the oxygen atom of the carbonyl group can only act as a hydrogen acceptor in C-H...O type hydrogen bonds.Such bonds form between the oxygen atom and the hydrogen atom located in the para position relative to the -CO(CH 3 ) group of the neighboring molecule.Due to these bonds, acetophenone forms a chain, which runs along the [1 0 1] direction.The translation vector in this direction is 11.14 Å.The length of the O...H bond is 2.46 Å and the D-H...A angle is 160 • .The symmetry of this supramolecular structure is described by the rod group pc.The 1-D hydrogen-bonded network further develops via hydrogen bonds, in which the acceptor...hydrogen distances are 2.48 Å.These bonds connect the chains of acetophenone molecules into a layer where each oxygen is involved into two different hydrogen bonds; one of the hydrogen atoms is connected to an atom from the aromatic ring, and the other is part of the methyl group (Figure 9a).The C(8)-H(8A)...O(1 ′ ) angle is 166 • .This is a layer with pa symmetry.The layers are arranged in the (001) plane (Figure 9b).A third type of hydrogen bonds, i.e., C(5)-H(5)...O(1 ′ ), connect the layers.They are characterized by the distance H(5)...O(1 ′ ), which is 2.69 Å, and the angle D-H...A (127 • ).The symmetry of the resulting supramolecular structure is described by the Space Group P2 1 /n.The formed 3-D network is shown in Figure 9c.
In order to investigate whether the changes in the geometric parameters resulting from the presence of a bulky group at the C(7) atom instead of a methyl group in the alcohol are due to the change of substituent or the OH…O hydrogen bonds formed, the ketone was crystallized and the structure was analyzed.In the obtained single crystal, the molecules of 1-(2,4,6-triisopropylphenyl)ethanone crystallize in the monoclinic system in the P21/n Space Group.The same was found by Blair et al. [50].It can be seen in Figure 9 that the unsubstituted ketone, acetophenone (ACETPH, structural data from [51]), forms hydrogen-bonded networks via C-H…O bonds.This ketone is very similar to those reduced in this study, except that it lacks substituents.Therefore, it can serve as a baseline for the comparison with a similar molecule with bulky isopropyl substituents.In the crystal of acetophenone, the oxygen atom of the carbonyl group can only act as a hydrogen acceptor in C-H...O type hydrogen bonds.Such bonds form between the oxygen atom and the hydrogen atom located in the para position relative to the -CO(CH3) group of the neighboring molecule.Due to these bonds, acetophenone forms a chain, which runs along the [1 0 1] direction.The translation vector in this direction is 11.14 Å.The length of the O...H bond is 2.46 Å and the D-H...A angle is 160°.The symmetry of this supramolecular structure is described by the rod group pc.The 1-D hydrogen-bonded network further develops via hydrogen bonds, in which the acceptor...hydrogen distances are 2.48 Å.These bonds connect the chains of acetophenone molecules into a layer where each oxygen is involved into two different hydrogen bonds; one of the hydrogen atoms is connected to an atom from the aromatic ring, and the other is part of the methyl group (Figure 9a).The C(8)-H(8A)...O(1′) angle is 166°.This is a layer with pa symmetry.The layers are arranged in the (001) plane (Figure 9b).A third type of hydrogen bonds, i.e., C(5)-H(5)...O(1′), connect the layers.They are characterized by the distance H(5)...O(1′), which is 2.69 Å, and the angle D-H...A (127°).The symmetry of the resulting supramolecular structure is described by the Space Group P21/n.The formed 3-D network is shown in Figure 9c.The molecular crystals of 1-(2,4,6-triisopropylphenyl)ethanone were grown independently by us and by Blair et al. [50].Apart from the fact that in the latter study, the refined structure was modeled with disorder in two isopropyl groups, whereas our molecule was modeled with disorder only in the substituent in the para position, the most important parameters and values are very similar.Our studies have shown that unlike the molecules of acetophenone (ACETPH), those of the studied ketone do not form any hydrogen-bonded networks via a C-H…O type bond.The arrangement of the molecules in The molecular crystals of 1-(2,4,6-triisopropylphenyl)ethanone were grown independently by us and by Blair et al. [50].Apart from the fact that in the latter study, the refined structure was modeled with disorder in two isopropyl groups, whereas our molecule was modeled with disorder only in the substituent in the para position, the most important parameters and values are very similar.Our studies have shown that unlike the molecules of acetophenone (ACETPH), those of the studied ketone do not form any hydrogen-bonded networks via a C-H. ..O type bond.The arrangement of the molecules in both our crystal (Figure 10a) and that obtained by Blair et al. [50] is very similar.These parameters were compared with those for acetophenone, which has the same arrangement of atoms except for the lack of substituents in the benzene ring, as well as one more compound from CSD in which there are isopropyl groups in both ortho positions and in the para position relative to the carbonyl group: (3RS,1 ′ RS)-1-methyl-3(1 ′ -methyl-3 ′ -oxo-3 ′ -(2,4,6triisopropylphenyl)propyl)-2-pyrrolidinone (KECDIF [52]).The numbering of carbon atoms is shown in Figure 10b,c.Selected bond lengths, angles and torsion angles of 1-(2,4,6triisopropylphenyl)ethanone and the appropriate fragments of KECDIF and acetophenone are listed in Table 1.Changes in geometric parameters resulting from the presence of a bulky group at the C(7) atom instead of a methyl group were determined by comparing the parameters in the molecules of 1-(2,4,6-triisopropylphenyl)ethanone with the appropriate parameters in molecules of KECDIF.
both our crystal (Figure 10a) and that obtained by Blair et al. [50] is very similar.These parameters were compared with those for acetophenone, which has the same arrangement of atoms except for the lack of substituents in the benzene ring, as well as one more compound from CSD in which there are isopropyl groups in both ortho positions and in the para position relative to the carbonyl group: (3RS,1′RS)-1-methyl-3(1′-methyl-3′-oxo-3′-(2,4,6-triisopropylphenyl)propyl)-2-pyrrolidinone (KECDIF [52]).The numbering of carbon atoms is shown in Figure 10b,c.Selected bond lengths, angles and torsion angles of 1-(2,4,6-triisopropylphenyl)ethanone and the appropriate fragments of KECDIF and acetophenone are listed in Table 1.Changes in geometric parameters resulting from the presence of a bulky group at the C(7) atom instead of a methyl group were determined by comparing the parameters in the molecules of 1-(2,4,6-triisopropylphenyl)ethanone with the appropriate parameters in molecules of KECDIF.As in 1-(2,4,6-triisopropylphenyl)ethanone and in KECDIF, in acetophenone molecules, all atoms constituting the aromatic ring lie in the plane of the aromatic ring calculated by the least squares method.Unlike the angles in ketones containing isopropyl groups in both ortho positions and in the para position relative to the -CO(CH 3 ) group, the angles in acetophenone are not differentiated.In molecules of both acetophenone and 1-(2,4,6triisopropylphenyl)ethanone, the C(7) atom is connected to the oxygen O(1) and to a methyl group.The O(1)-C(7)-C(8) angle has the same value in both.These groups differ primarily in the value of the dihedral angle (α) formed by the plane containing O(1), C(7) and C(8) atoms with the plane of the aromatic ring, which is 90 • in 1-(2,4,6-triisopropylphenyl)ethanone, whereas in acetophenone, it is only 4 • .
The work of Kunicki and co-workers described the trend observed in ketones containing -CO(CH 3 ) groups between the value of the aforementioned angle and the bond length of the carbon atom of the aromatic ring with the carbon atom of the carbonyl group [21].The larger the angle α, the smaller the coupling of the sextet of electrons of the aromatic ring with the π electrons of the C(7)-O(1) bond.In the case of 1-(2,4,6triisopropylphenyl)ethanone and acetophenone, despite the significant difference in the values of α angles, the lengths of the C(1)-C(7) bonds are the same.The most likely cause of the elongation of the carbon-carbonyl bond in acetophenone molecules are intermolecular interactions in which part of the electrons of the O(1) atom are involved.The acetophenone crystal contains layers formed by two different hydrogen bonds of the C-H...O type.The oxygen atom interacts with the hydrogen atom of the carbon atom in the para position relative to the -CO(CH 3 ) group and with one of the hydrogens at the C(8) atom.A greater share of the hyperconjugation effect in 1-(2,4,6-triisopropylphenyl)ethanone than in

Figure 6 .
Figure 6.View of hydrogen bonds in hexamers of (a) 1-(2,4,6-trimethylphenyl)ethanol, (b) VATSAK02, (c) IPMEPL and (d) QEBBII in the unit cell in the [0 0 1] direction.1-(2,4,6-Triisopropylphenyl)ethanol crystallizes in the triclinic system in the P1 Space Group.Four of the eight molecules in the unit cell are independent.There are four independent molecules of this compound in the unit cell (Figure 7a).The numbering scheme is shown on the first molecule.The bonds of the carbon atoms of the benzene ring with the carbon atoms of the isopropyl groups in 1-(2,4,6-triisopropylphenyl)ethanol are 1.51-1.53Ǻ.The angles C(1)-C(2)-C(9) and C(1)-C(6)-C(11) in the molecules are all larger than 120 • by 2-4 • , whereas the angle C (3)-C(4)-C(10) is 121-123 • .The C(9) and C(11) atoms of the B molecule of 1-(2,4,6-triisopropylphenyl)ethanol lie in the plane of the aromatic ring of this molecule.In molecule A, the C(10) atom lies in the plane of the aromatic ring.In molecules A, B and C, atoms C(9), C(10) and C(11) lean out from the plane containing atoms C(1), C(2), C(3), C(4), C(5) and C(6) by a maximum of 0.057 Ǻ.In molecule D, these atoms deflect by 0.1 to 0.2 Ǻ from the plane of the aromatic ring.The values of the torsion angles C(5)-C(6)-C(11)-C(16) and C(5)-C(6)-C(11)-C(17) are the same in molecules A and B. They are −96 • and 28 • , respectively.The values of these angles in the other two molecules of this alcohol are similar, and in these molecules, they are, respectively, −60 • and 64 • .All four independent molecules of 1-(2,4,6-triisopropylphenyl)ethanol engage in strong O-H. ..O hydrogen bonds, which leads to the formation of tetramers.This is significantly different than in the case of the alcohol with methyl substituents.The bulkier substituents lead to having fewer molecules in the assembly.The diagram of the resulting tetramer is shown in Figure 7b.It can be seen that the centrosymmetric tetramers exhibit an S-S-R-R configuration.

Figure 7 .
Figure 7. Images of (a) the four independent molecules of 1-(2,4,6-triisopropylphenyl)ethanol without hydrogen atoms other than the hydroxyl hydrogen and (b) scheme of the formed tetramer; R = 2,4,6-triisopropylphenyl.There are two types of tetramers formed in the unit cell.Tetramer #1 consists of A and B molecules arranged alternately.The hydrogen-bond acceptor distances in Tetramer #1 are 1.91 Ǻ and 1.96 Ǻ.These tetramers align perpendicular to the [0 0 1] direction, as shown in Figure 8a.Each C molecule connects with two D molecules via two O-H...O type hydrogen bonds.The distances H(1)...O(1′) in these bonds are 1.91 Ǻ and 1.95 Ǻ, respectively.The centers of Tetramers #2 are shifted relative to the centers of Tetramers #1 by half a unit vector in the [0 0 1] direction.Figure 8b illustrates the chiral carbon atoms in the molecules of 1-(2,4,6-triisopropylphenyl)ethanol and all the atoms connected to them.The configuration of the corresponding molecules is the same on the corresponding carbon atoms.In order to compare tetramers formed by O-H...O hydrogen-bonded molecules of 1-(2,4,6-triisopropylphenyl)ethanol with similar tetramers, a detailed review of the CSD database was performed.Dozens of compounds were found whose molecules combine into tetramers with O-H...O hydrogen bonds.Most of them are centrosymmetric tetramers.

Figure 8 .
Figure 8. Arrangement of (a) tetramers in the unit cell perpendicular to the [1 0 0] direction, and (b) the O-H...O hydrogen bonds and carbon atoms connected to the chiral C(7) atom.

Figure 7 .
Figure 7. Images of (a) the four independent molecules of 1-(2,4,6-triisopropylphenyl)ethanol without hydrogen atoms other than the hydroxyl hydrogen and (b) scheme of the formed tetramer; R = 2,4,6-triisopropylphenyl.There are two types of tetramers formed in the unit cell.Tetramer #1 consists of A and B molecules arranged alternately.The hydrogen-bond acceptor distances in Tetramer #1 are 1.91 Ǻ and 1.96 Ǻ.These tetramers align perpendicular to the [0 0 1] direction, as shown in Figure 8a.Each C molecule connects with two D molecules via two O-H...O type hydrogen bonds.The distances H(1)...O(1 ′ ) in these bonds are 1.91 Ǻ and 1.95 Ǻ, respectively.The centers of Tetramers #2 are shifted relative to the centers of Tetramers #1 by half a unit vector in the [0 0 1] direction.Figure 8b illustrates the chiral carbon atoms in the molecules of 1-(2,4,6-triisopropylphenyl)ethanol and all the atoms connected to them.The configuration of the corresponding molecules is the same on the corresponding carbon atoms.In order to compare tetramers formed by O-H...O hydrogen-bonded molecules of 1-(2,4,6-triisopropylphenyl)ethanol with similar tetramers, a detailed review of the CSD database was performed.Dozens of compounds were found whose molecules combine into tetramers with O-H...O hydrogen bonds.Most of them are centrosymmetric tetramers.

Figure 7 .
Figure 7. Images of (a) the four independent molecules of 1-(2,4,6-triisopropylphenyl)ethanol without hydrogen atoms other than the hydroxyl hydrogen and (b) scheme of the formed tetramer; R = 2,4,6-triisopropylphenyl.There are two types of tetramers formed in the unit cell.Tetramer #1 consists of A and B molecules arranged alternately.The hydrogen-bond acceptor distances in Tetramer #1 are 1.91 Ǻ and 1.96 Ǻ.These tetramers align perpendicular to the [0 0 1] direction, as shown in Figure 8a.Each C molecule connects with two D molecules via two O-H...O type hydrogen bonds.The distances H(1)...O(1′) in these bonds are 1.91 Ǻ and 1.95 Ǻ, respectively.The centers of Tetramers #2 are shifted relative to the centers of Tetramers #1 by half a unit vector in the [0 0 1] direction.Figure 8b illustrates the chiral carbon atoms in the molecules of 1-(2,4,6-triisopropylphenyl)ethanol and all the atoms connected to them.The configuration of the corresponding molecules is the same on the corresponding carbon atoms.In order to compare tetramers formed by O-H...O hydrogen-bonded molecules of 1-(2,4,6-triisopropylphenyl)ethanol with similar tetramers, a detailed review of the CSD database was performed.Dozens of compounds were found whose molecules combine into tetramers with O-H...O hydrogen bonds.Most of them are centrosymmetric tetramers.

Figure 8 .
Figure 8. Arrangement of (a) tetramers in the unit cell perpendicular to the [1 0 0] direction, and (b) the O-H...O hydrogen bonds and carbon atoms connected to the chiral C(7) atom.

Figure 8 .
Figure 8. Arrangement of (a) tetramers in the unit cell perpendicular to the [1 0 0] direction, and (b) the O-H...O hydrogen bonds and carbon atoms connected to the chiral C(7) atom.

Figure 9 .
Figure 9. Acetophenone molecules assembled into a chain via C-H…O type hydrogen bonds: (a) view of the chain along the [0 1 0] direction; (b) layer of acetophenone molecules; and (c) the 3-D network formed via the third type of hydrogen bonds.

Figure 9 .
Figure 9. Acetophenone molecules assembled into a chain via C-H. ..O type hydrogen bonds: (a) view of the chain along the [0 1 0] direction; (b) layer of acetophenone molecules; and (c) the 3-D network formed via the third type of hydrogen bonds.

Table 1 .
Selected bond lengths, angles and torsion angles in the molecule of 1-(2,4,6triisopropylphenyl)ethanone and the corresponding fragments in acetophenone and KECDIF.