New Molecular Mechanisms and Clinical Impact of circRNAs in Human Cancer
Abstract
:Simple Summary
Abstract
1. Introduction
2. A Variety of circRNA/RBP Complexes with Diverse Functions: Beyond miRNA Sponging Activity
2.1. circRNAs’ Ability to Interact with Proteins and to Function as Protein Decoys
2.2. circRNAs Enhancing Protein Complexes Formation and/or Activity
2.3. circRNA Permitting the Interaction between Different Proteins
2.4. Transcriptional Regulation
2.5. Control of the Expression of Parental Genes: Control of Transcription Initiation
2.6. Control of the Expression of Parental Genes: Control of Transcription Elongation
2.7. Regulation of Protein Scaffold in Impacting Translation
3. Translation of circRNAs in Human Cancer
4. Regulation of Immune Functions by circRNA
5. Functions of circRNAs in the Exosomes
6. circRNAs in the Drug Resistance
7. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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circRNAs | Targets or Biological Output | Molecular Function | Cancer Type | Ref. |
---|---|---|---|---|
circAmotl1 | c-Myc | Interaction with proteins and to function as protein decoys | Breast | [18,19] |
Stat3 | ||||
circFoxo3 | ID-1 | Interaction with proteins and to function as protein decoys | [20] | |
FAK | ||||
HIF-1a | ||||
E2F1 | ||||
circPABPN1 | PABPN1 | Interaction with proteins and to function as protein decoys | Cervical | [21] |
circPCNX | AUF1 | Interaction with proteins and to function as protein decoys | Cervical | [22] |
circMALAT1 | PAX5 | Enhancing protein complexes formation and/or activity | Hepatocellular | [23] |
circNSUN2 | IGF2BP2 | Enhancing protein complexes formation and/or activity | Colorectal | [24] |
HMGA2 | ||||
circYAP | YAP | Enhancing protein complexes formation and/or activity | Breast | [25] |
eIF4G | ||||
PABP | ||||
circPOK | ILF2/3 | Enhancing protein complexes formation and/or activity | Sarcoma | [26] |
IL-6 | ||||
VEGF | ||||
circFoxo3 | MDM2 | Interaction between different proteins | Breast | [20] |
p53 | [27] | |||
p21 | [27] | |||
circCcnb1 | H2AX | Interaction between different proteins | Breast | [28] |
Wild type-p53 | ||||
Bclaf1 | ||||
circANRIL | PES1 | Interaction between different proteins | [29] | |
circGSK3β | β-catenin | Interaction between different proteins | Esophageal | [30] |
circDONSON | SOX4 | Transcriptional regulation | Gastric | [31] |
Liver | ||||
circHOT1 | TIP60 | Transcriptional regulation | Hepatocellular | [32] |
NR2F6 | ||||
circEIF3J | U1 snRNP | Control of the expression of parental genes: control of transcription initiation | Cervical | [33] |
circPAIP2 | U1 snRNP | Control of the expression of parental genes: control of transcription initiation | Cervical | [33] |
circXIAP | FUS | Control of the expression of parental genes: control of transcription initiation | Prostate | [34] |
XIAP | ||||
FECR1 | TET1 | Control of the expression of parental genes: control of transcription initiation | Breast | [35] |
FLI1 | ||||
circCUX1 | EWSR1 | Control of the expression of parental genes: control of transcription initiation | Neuroblastoma | [36] |
ci-ankrd52 | ankrd52 | Control of the expression of parental genes: control of transcription elongation | Cervical | [37] |
Hsa_circ_0075804 | HNRNPK | Regulation of protein scaffold to impact on the translation | Retinoblastoma | [38] |
circBACH1 | HuR | Regulation of protein scaffold to impact on the translation | Hepatocellular | [39] |
circZNF609 | translated | Translation | [40] | |
circβ-catenin | β-catenin-370aa | Translation | Hepatocellular | [41] |
circFBXW7 | FBXW7-185aa | Translation | Glioma Breast | [42,43] |
circ_0020397 | miR-138 | Regulation of immune functions | Colorectal | [44] |
circ_0020710 | miR-370-3p | Regulation of immune functions | Melanoma | [45] |
circMET | miR-30-5p | Regulation of immune functions | Hepatocellular | [46] |
CDR1-AS | miR-7 | Functions in exosomes | Brain | [47,48] |
circPDE8A | EMT | Functions in exosomes | PDAC | [49] |
circIARS | RhoA | Functions in exosomes | Pancreatic | [50] |
RhoA-GTP | ||||
circ_17720 | cancer recurrence | Functions in exosomes | Prostate | [51] |
circ_178252 | ||||
circ_115617 | ||||
circ_14736 | ||||
circ_30029 | ||||
circ_117300 | ||||
circ_176436 | ||||
circ_112897 | ||||
circSATB2 | miR-326 | Functions in exosomes | Lung | [52] |
circWHSC1 | miR-145 | Functions in exosomes | Ovarian | [53] |
Hsa_circ_0032883 | chemosensitivity | Drug resistance | Colorectal | [54] |
Hsa_circ_0020095 | miR-487a-3p | Drug resistance | Colorectal | [55] |
circ-FBXW7 | miR-18b-5p | Drug resistance | Colorectal | [56] |
circ_0005963 | miR-122 | Drug resistance | Colorectal | [57] |
circGFRA1 | miR-361-5p | Drug resistance | Breast | [58] |
circNRIP1 | miR-211-5p | Drug resistance | Ovarian | [59] |
circFoxp1 | miR-22 | Drug resistance | Ovarian | [60] |
miR-150-3p | ||||
Hsa_circ_0002874 | miR-1273f | Drug resistance | Lung | [61] |
Hsa_circ_0001946 | NER signaling pathway | Drug resistance | Lung | [62] |
circUHRF1 | Resistance to anti-PD1 immunotherapy | Drug resistance | Hepatocellular | [63] |
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Fontemaggi, G.; Turco, C.; Esposito, G.; Di Agostino, S. New Molecular Mechanisms and Clinical Impact of circRNAs in Human Cancer. Cancers 2021, 13, 3154. https://doi.org/10.3390/cancers13133154
Fontemaggi G, Turco C, Esposito G, Di Agostino S. New Molecular Mechanisms and Clinical Impact of circRNAs in Human Cancer. Cancers. 2021; 13(13):3154. https://doi.org/10.3390/cancers13133154
Chicago/Turabian StyleFontemaggi, Giulia, Chiara Turco, Gabriella Esposito, and Silvia Di Agostino. 2021. "New Molecular Mechanisms and Clinical Impact of circRNAs in Human Cancer" Cancers 13, no. 13: 3154. https://doi.org/10.3390/cancers13133154