Distinct Clinical Impact and Biological Function of Angiopoietin and Angiopoietin-like Proteins in Human Breast Cancer
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Genomic Alterations in ANGPT/ANGPTL Genes in Breast Cancers
3.2. Prognostic Impact of ANGPT/ANGPTL Genes in Breast Cancer Patients
3.3. Molecular-Subtype-Dependent Prognostic Impact of ANGPT/ANGPTL Genes in Breast Cancers
3.4. Biological Functions of ANGPT/ANGPTL Genes in Breast Cancers Elucidated via Gene Co-Expression Network
3.5. Correlation of ANGPT/ANGPTL Genes with Biological Factors in the Tumor Microenvironment of Breast Cancers
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gene Name | TCGA (%) | COSMIC (%) |
---|---|---|
ANGPT1 | 0.9 | 4.42 |
ANGPT2 | 0.3 | 1.59 |
ANGPT4 | 1.0 | 2.29 |
ANGPTL1 | 0.6 | 1.05 |
ANGPTL2 | 0.0 | 0.93 |
ANGPTL3 | 0.5 | 0.35 |
ANGPTL4 | 0.2 | 0.70 |
ANGPTL5 | 0.4 | 1.16 |
ANGPTL6 | 0.1 | 0.81 |
ANGPTL7 | 0.1 | 0.39 |
ANGPTL8 | 0.1 | 0.27 |
Gene Name | Positive Correlation | Negative Correlation |
---|---|---|
ANGPT1 | 483 | 14 |
ANGPT2 | 209 | 0 |
ANGPT4 | 722 | 92 |
ANGPTL1 | 1255 | 185 |
ANGPTL2 | 1245 | 30 |
ANGPTL3 | 0 | 0 |
ANGPTL4 | 104 | 0 |
ANGPTL5 | 169 | 0 |
ANGPTL6 | 263 | 0 |
ANGPTL7 | 506 | 0 |
ANGPTL8 | 113 | 0 |
Gene Name | Immune Score | Stroma Score | Microenvironment Score | Cancer Associated Fibroblast | Endothelial Cell | |||||
---|---|---|---|---|---|---|---|---|---|---|
Rho | p-Value | Rho | p-Value | Rho | p-Value | Rho | p-Value | Rho | p-Value | |
ANGPT1 | 0.174 | 3.423 × 10−8 | 0.406 | 1.123 × 10−40 | 0.443 | 5.859 × 10−49 | 0.319 | 6.515 × 10−25 | 0.344 | 6.856 × 10−29 |
ANGPT2 | −0.024 | 0.447 | 0.271 | 4.090 × 10−18 | 0.113 | 3.749 × 10−4 | 0.170 | 6.527 × 10−8 | 0.430 | 4.873 × 10−46 |
ANGPT4 | −0.007 | 0.830 | 0.538 | 1.529 × 10−75 | 0.354 | 1.201 × 10−30 | 0.449 | 1.595 × 10−50 | 0.486 | 7.086 × 10−60 |
ANGPTL1 | 0.093 | 0.003 | 0.713 | 3.875 × 10−155 | 0.536 | 6.213 × 10−75 | 0.627 | 1.192 × 10−109 | 0.579 | 4.948 × 10−90 |
ANGPTL2 | 0.073 | 0.022 | 0.646 | 1.691 × 10−118 | 0.430 | 4.654 × 10−46 | 0.637 | 2.645 × 10−114 | 0.475 | 4.841 × 10−57 |
ANGPTL3 | −0.024 | 0.458 | 0.015 | 0.635 | 0.006 | 0.856 | 0.018 | 0.566 | 0.020 | 0.524 |
ANGPTL4 | 0.002 | 0.945 | 0.373 | 4.689 × 10−34 | 0.258 | 1.649 × 10−16 | 0.262 | 5.285 × 10−17 | 0.277 | 5.923 × 10−19 |
ANGPTL5 | 0.049 | 0.124 | 0.394 | 2.990 × 10−38 | 0.303 | 1.452 × 10−22 | 0.326 | 5.901 × 10−26 | 0.324 | 1.146 × 10−25 |
ANGPTL6 | 0.355 | 7.858 × 10−31 | 0.168 | 9.353 × 10−8 | 0.390 | 1.809 × 10−37 | 0.185 | 4.235 × 10−9 | 0.121 | 1.268 × 10−4 |
ANGPTL7 | −0.043 | 0.180 | 0.488 | 1.916 × 10−60 | 0.313 | 5.412 × 10−24 | 0.435 | 3.310 × 10−47 | 0.387 | 6.403 × 10−37 |
ANGPTL8 | −0.100 | 0.002 | 0.440 | 3.182 × 10−48 | 0.224 | 9.426 × 10−13 | 0.316 | 1.822 × 10−24 | 0.372 | 5.360 × 10−34 |
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Yang, H.; Zhang, M.; Mao, X.-Y.; Chang, H.; Perez-Losada, J.; Mao, J.-H. Distinct Clinical Impact and Biological Function of Angiopoietin and Angiopoietin-like Proteins in Human Breast Cancer. Cells 2021, 10, 2590. https://doi.org/10.3390/cells10102590
Yang H, Zhang M, Mao X-Y, Chang H, Perez-Losada J, Mao J-H. Distinct Clinical Impact and Biological Function of Angiopoietin and Angiopoietin-like Proteins in Human Breast Cancer. Cells. 2021; 10(10):2590. https://doi.org/10.3390/cells10102590
Chicago/Turabian StyleYang, Hui, Melody Zhang, Xuan-Yu Mao, Hang Chang, Jesus Perez-Losada, and Jian-Hua Mao. 2021. "Distinct Clinical Impact and Biological Function of Angiopoietin and Angiopoietin-like Proteins in Human Breast Cancer" Cells 10, no. 10: 2590. https://doi.org/10.3390/cells10102590