Stroke rehabilitation: from diagnosis to therapy

Stroke remains a significant global health burden, necessitating comprehensive and innovative approaches in rehabilitation to optimize recovery outcomes. This paper provides a thorough exploration of rehabilitation strategies in stroke management, focusing on diagnostic methods, acute management, and diverse modalities encompassing physical, occupational, speech, and cognitive therapies. Emphasizing the importance of early identification of rehabilitation needs and leveraging technological advancements, including neurostimulation techniques and assistive technologies, this manuscript highlights the challenges and opportunities in stroke rehabilitation. Additionally, it discusses future directions, such as personalized rehabilitation approaches, neuroplasticity concepts, and advancements in assistive technologies, which hold promise in reshaping the landscape of stroke rehabilitation. By delineating these multifaceted aspects, this manuscript aims to provide insights and directions for optimizing stroke rehabilitation practices and enhancing the quality of life for stroke survivors.


Introduction
Stroke stands as a significant global burden, impacting millions of lives annually and presenting a substantial challenge to healthcare systems worldwide.Statistics from the World Health Organization (WHO) reveal that stroke is a leading cause of mortality and disability globally.Annually, approximately 13.7 million new cases of stroke are reported, making it a prevalent health issue across continents and demographics (1).The latest findings from the 2019 Global Burden of Disease (GBD) report revealed that stroke continues to hold its position as the second leading cause of mortality and the third leading cause of mortality and disability combined, measured in terms of disability-adjusted life-years lost (DALYs) worldwide (2).The projected economic impact of stroke globally exceeds US$891 billion, accounting for approximately 1.12% of the global Gross Domestic Product (GDP) (3).Between 1990 and 2019, there was a significant surge in the burden of stroke, indicated by a 70.0% rise in new stroke cases, a 43.0%increase in stroke-related deaths, a 102.0%uptick in existing stroke cases, and a 143.0%elevation in DALYs.The majority of the worldwide burden of stroke, accounting for 86.0% of deaths and 89.0% of DALYs, was observed in countries categorized as lowerincome and lower-middle-income countries (LMIC).
Considerable variations were evident in age-standardized stroke incidence (six-fold), mortality (15-fold), prevalence (four-fold), and DALYs (20-fold) rates across different geographical regions.The regions with the highest rates were predominantly observed in LMIC, notably in Eastern Europe, Asia, and Sub-Saharan Africa (4).Beyond its high incidence, stroke accounts for a substantial number of deaths globally.Those who survive often experience varying degrees of disability, which significantly affects their quality of life (5).Disabilities resulting from stroke encompass motor impairments, cognitive deficits, speech and language difficulties, and psychological challenges (6).The aftermath of stroke extends beyond the individual affected, impacting families, caregivers, and society at large.The disabilities and long-term care needs of stroke survivors impose emotional, financial, and practical burdens on families (7,8).Furthermore, the societal cost is immense, encompassing healthcare expenses, loss of productivity, and the need for long-term rehabilitation and support services (9).Disparities in stroke incidence, management, and outcomes exist globally, often correlated with socio-economic factors (10).Low-and middle-income countries face greater challenges due to limited access to healthcare services, diagnostics, and rehabilitation facilities.These disparities contribute to higher mortality rates and poorer recovery outcomes in certain regions (11).
Efforts to reduce the global burden of stroke emphasize prevention through awareness campaigns targeting risk factors like hypertension, smoking, obesity, and physical inactivity (3).Additionally, interventions focusing on timely access to acute care, advanced treatments such as thrombolytic therapy, and comprehensive rehabilitation are crucial in mitigating the impact of stroke (12).Addressing the global burden of stroke necessitates collaborative efforts between governments, healthcare organizations, advocacy groups, and communities.Initiatives aimed at improving access to healthcare, enhancing stroke awareness, promoting healthier lifestyles, and advancing rehabilitation services are fundamental in reducing the burden of stroke on a global scale (13).The pervasive impact of stroke underscores the urgent need for concerted global action.Strategies encompassing prevention, timely intervention, access to quality healthcare, and comprehensive rehabilitation are essential to alleviate the burden of stroke and improve outcomes for individuals affected by this debilitating condition (14).This paper aims to provide a comprehensive overview of the evolving landscape of stroke rehabilitation, emphasizing the critical phases from diagnosis to therapy.By synthesizing current knowledge and highlighting emerging trends, this review intends to serve as a resource for clinicians, researchers, and policymakers involved in stroke care and rehabilitation.This manuscript endeavors to contribute to the evolving discourse on stroke rehabilitation by synthesizing and analyzing diverse literature from across the spectrum of stroke care.While not a systematic review in the traditional sense, this manuscript adopts a rigorous approach to literature selection, guided by clear inclusion criteria.These criteria prioritize relevance, quality, credibility, diversity of perspectives, and a keen focus on emerging technologies and innovations in stroke rehabilitation.Central to our approach is the recognition of the multifaceted nature of stroke rehabilitation.Each section of this manuscript delves into specific aspects of stroke care, from the early diagnosis and assessment to the implementation of rehabilitation programs across different stages of stroke recovery.By integrating evidence from various publication types, including original research articles, clinical trials, systematic reviews, metaanalyses, and review articles, we aim to provide a comprehensive overview of the current state of stroke rehabilitation.Moreover, our commitment to inclusivity extends beyond the traditional boundaries of stroke research.Efforts have been made to incorporate literature from diverse geographical regions, healthcare settings, and patient populations, acknowledging the unique challenges and perspectives that shape stroke rehabilitation practices globally.
Special attention is also given to the exploration of emerging technologies and innovations in stroke rehabilitation.From robotics to virtual reality and neurostimulation techniques, the evolving landscape of rehabilitation technology offers promising avenues for enhancing outcomes and improving the quality of life for stroke survivors.By embarking on this comprehensive review journey, we seek to not only consolidate existing knowledge but also identify gaps, challenges, and opportunities for future research and practice in stroke rehabilitation.Through our collective efforts, we aspire to contribute to the advancement of evidence-based, patient-centered care that optimizes outcomes and fosters resilience in the face of stroke.
The multifaceted field of stroke rehabilitation is explored in this review paper, providing a comprehensive overview of current practices, challenges, and future directions.The paper begins with a background on stroke rehabilitation, discussing its significance, historical context, and the evolution of practices.This section sets the stage for understanding the critical role of rehabilitation in stroke recovery.Next, current rehabilitation practices are examined, detailing interventions such as early rehabilitation strategies, physical therapy, occupational therapy, speech and language therapy, and cognitive rehabilitation.Each subsection highlights evidence-based practices and their impact on recovery.The challenges and opportunities in stroke rehabilitation are then addressed.Issues such as the lack of standardized timing for rehabilitation initiation, disparities in access to services, stroke-related infections, the need for individualized rehabilitation plans, and the importance of interdisciplinary collaboration are analyzed.Potential improvements and innovations are discussed.Finally, the future directions are explored.Emerging trends and advancements, including personalized rehabilitation approaches, the integration of neuroplasticity concepts, and the development of assistive technologies, are highlighted.These innovations are shown to have the potential to transform rehabilitation practices and improve outcomes for stroke survivors.This structured approach provides a clear roadmap for readers, ensuring a thorough coverage of each aspect of stroke rehabilitation.It offers valuable insights for clinicians, researchers, and stakeholders in the field.

Diagnosis of stroke: clinical assessment and imaging techniques
The clinical assessment of stroke involves a comprehensive evaluation that begins with taking the patient's medical history (Figure 1).This includes probing into risk factors such as hypertension, diabetes, smoking, previous strokes, or heart disease (15).A thorough physical examination follows, focusing on neurological assessments.This examination evaluates motor function, sensation, coordination, reflexes, and cranial nerve function (16).Utilizing scales like the NIH Stroke Scale (NIHSS) helps in quantifying the severity of stroke symptoms, aiding in treatment decisions (17).Additionally, determining the time of symptom onset is critical, as certain treatments like thrombolytic therapy have a limited window of effectiveness after symptom onset (18).Imaging serves as a pivotal component in selecting patients for intravenous and intra-arterial arterial ischemic stroke treatments.Techniques like computed tomography (CT) with CT angiography or magnetic resonance (MR) with MR angiography are employed to eliminate stroke mimics and hemorrhages, ascertain the stroke's cause and mechanism, delineate the extent of brain infarction, and pinpoint arterial blockages ( 19).Imaging has the potential to discern patients who would derive greater benefit from revascularization therapies, irrespective of the traditional therapeutic time frame.This capability allows for personalized treatment decisions, enhancing individual patient outcomes significantly (20).Multiparametric CT/MR imaging can determine the scope of potentially salvageable brain tissue (penumbra) and irreversible brain damage (core) by leveraging CT perfusion and/or diffusion-weighted and perfusion-weighted MR imaging (21,22).Additionally, the imaging of diffusion-weighted techniques aids in evaluating the status of arterial collateral circulation and discerning the type and spread of the clot (23).
The primary goals of arterial ischemic stroke imaging involve excluding hemorrhage and stroke mimics and identifying optimal candidates for IV or IA treatments, considering both the extent of confirmed brain damage (core) and the location of arterial blockages (24,25).Arterial ischemic strokes are urgent medical situations where treatment decisions (ranging from conservative approaches to IV thrombolysis and/or mechanical revascularization) hinge on two crucial imaging factors: the timeframe since onset and two primary features observed in imaging-parenchymal lesions and arterial blockage locations (26,27).Imaging of the parenchyma is vital for confirming the diagnosis and gauging the extent of ischemic damage, while vascular imaging, conducted through CT/CTA or MRI/MRA, is essential for pinpointing the location of arterial blockages in arterial ischemic stroke evaluations (28,29).Supplementary details about collateral flow, penumbra, and core extension can significantly enhance the precision of individual treatment decisions.The selection of the initial imaging modality for arterial ischemic stroke assessment is largely influenced by the immediate 24/7 equipment accessibility and its capability to furnish vital information necessary for various treatment approaches (29,30).Due to its broader availability, CT stands as the most widely utilized imaging technique globally for acute stroke.Transcranial Doppler (TCD) utilizes ultrasound to assess blood flow in the brain's blood vessels, aiding in the evaluation of stroke and identifying conditions like vasospasm, providing valuable insights into the vascular aspects of stroke pathology (31).Telemedicine and mobile imaging have revolutionized stroke care, particularly in areas with limited access to specialized stroke expertise.The most reliable test for clinical assessment of stroke.Remote evaluation of stroke patients using telemedicine enables timely assessment and consultation with stroke specialists, facilitating rapid decision-making and treatment initiation (32).Artificial intelligence (AI) is increasingly being integrated into imaging analysis, showing promising results in quickly and accurately detecting stroke.AI-assisted analysis helps clinicians by providing rapid insights into imaging data, aiding in prompt diagnosis and subsequent treatment planning (33).Emerging research highlights the capacity of AI to enhance stroke prognosis.Lukić et al. (34) pioneered an artificial neural network (ANN)-driven framework for predicting outcomes in cases of stroke.Meanwhile, Wang et al. (35) utilized machine learning to construct a random forest model for stroke prognosis.Additionally, Xu et al. (36) amalgamated CT radiomics with machine learning methods to devise stroke prognostic models integrating 18 CT imaging attributes.These novel approaches have optimized the selection of risk factors and expanded the inclusion of imaging features, thus bolstering predictive precision.Moreover, deep learning has surfaced as a hopeful avenue for prognostic forecasting leveraging imaging data.Chen et al. (37) formulated a predictive model centered on convolutional neural networks (CNNs), blending clinical data with extensive imaging characteristics to address prior constraints of stroke prognostic frameworks.Their results indicate heightened predictive efficacy of the clinic-imaging fusion CNN model.This model stands poised for integration into clinical practice, offering the prospect of enhanced management for ICH patients.These technological advancements in stroke diagnosis significantly improve the speed and accuracy of assessments, allowing for rapid initiation of appropriate treatments, thereby minimizing brain damage and enhancing the prospects of recovery for stroke patients.

Early identification of rehabilitation needs
Upon a patient's arrival following a stroke, a comprehensive clinical assessment is crucial.This assessment involves a detailed evaluation of the patient's neurological status, encompassing motor function, sensation, coordination, and cognitive abilities.It helps in swiftly identifying any deficits or impairments resulting from the stroke (38).Additionally, assessing speech, language, and swallowing abilities early on is vital.This immediate evaluation assists in identifying any communication impairments or dysphagia, indicating the need for specialized speech and language therapy (39).
Utilizing tools such as NIHSS aids in objectively quantifying the severity of stroke symptoms.This assessment provides critical information to healthcare professionals about the extent and severity of impairments, guiding decisions on the urgency and intensity of rehabilitation interventions (40).Functional assessments, like the Functional Independence Measure (FIM), play a crucial role in determining the patient's level of independence in performing activities of daily living (ADLs).These assessments aid in highlighting specific areas requiring focused rehabilitation efforts (41).As mentioned previously, imaging techniques, such as CT scans MRI not only confirm the diagnosis of stroke but also offer insights into the location and extent of brain damage.Integrating these imaging findings with clinical deficits assists in understanding the specific deficits correlated with affected brain regions.This correlation is pivotal in guiding the development of targeted rehabilitation strategies tailored to the individual's needs (21,42).
Initiating rehabilitation interventions as early as possible poststroke, even within the acute phase, is associated with improved outcomes.Early interventions may involve passive range-of-motion exercises, early mobilization, or cognitive stimulation exercises.These early initiatives aim to prevent secondary complications, promote neural plasticity, and lay the groundwork for subsequent rehabilitation efforts (43,44).Concurrently, setting rehabilitation goals in collaboration with the patient and their caregivers helps establish a clear direction for therapy.These goals are individualized, realistic, and aimed at improving functional abilities based on the identified impairments (45).Involving a multidisciplinary team comprising various specialists-such as physiotherapists, occupational therapists, speech-language pathologists, psychologists, and social workers-is instrumental.This collaborative approach ensures a comprehensive assessment and identification of rehabilitation needs from various perspectives.Each specialist brings unique expertise to the table, contributing to the development of a holistic rehabilitation plan tailored to the patient's specific impairments and goals (14).Furthermore, engaging family members or caregivers right from the beginning allows them to grasp the rehabilitation process, receive training on assisting the patient, and create a supportive environment upon the patient's discharge (46).Early identification of stroke rehabilitation needs through a comprehensive and interdisciplinary approach sets the stage for a focused, individualized, and timely rehabilitation plan, significantly impacting the trajectory of recovery for stroke survivors (47).

Stages of stroke and corresponding rehabilitation programs
Stroke recovery is typically categorized into three stages: acute, subacute, and chronic.Each stage has distinct characteristics and rehabilitation needs, which are critical for optimizing patient outcomes (Table 1).

Acute stage of stroke
The acute stage of stroke encompasses the first 24 h to 1 week following the onset of the stroke.During this initial phase, the primary focus is on medical stabilization and preventing further brain damage (99).Immediate medical interventions are crucial, including measures to restore blood flow, such as the administration of tissue plasminogen activator (tPA) for ischemic strokes or surgical procedures to address hemorrhagic strokes (100).Early rehabilitation efforts aim to prevent complications, such as deep vein thrombosis, pressure sores, and contractures.Gentle mobilization, proper positioning, and passive range of motion exercises are implemented to maintain some level of physical function.Basic activities of daily living (ADL) training, including assistance with eating, dressing, and personal hygiene, are introduced to help patients maintain a degree of independence.Psychological support is also essential at this stage to help patients and their families cope with the emotional impact of the stroke (101).

Subacute stage of stroke
The subacute stage occurs from 1 week to three to 6 months poststroke.This phase is marked by more intensive rehabilitation efforts aimed at promoting neurological recovery and improving functional abilities (102).During the subacute stage, patients typically engage in comprehensive rehabilitation programs that include physical therapy, occupational therapy, and speech and language therapy.Physical therapy focuses on improving strength, coordination, balance, and mobility through exercises and activities tailored to the patient's needs (103).Occupational therapy helps patients regain the ability to perform daily tasks, such as dressing, bathing, and cooking, by using techniques like constraint-induced movement therapy (CIMT) and dual-task training (104).Proprioceptive training is also incorporated to enhance the patient's sense of body position and movement (105).Speech and language therapy continues to address communication and swallowing difficulties (106).Psychological counseling and support remain vital to address any emotional and cognitive challenges that arise during this phase of recovery (107).

Chronic stage of stroke
The chronic stage of stroke begins 6 months after the initial event and extends indefinitely.During this phase, the focus shifts to longterm rehabilitation and the management of any residual disabilities.The goal is to maintain and further improve functional abilities while helping patients adapt to their long-term needs (55).Rehabilitation interventions in the chronic stage often include community-based programs, which provide ongoing therapy and support.Advanced therapies such as robot-assisted therapy and virtual reality training are used to enhance motor skills and cognitive functions (108).Functional electrical stimulation (FES) may be employed to improve muscle function, and mirror therapy can be used to create the illusion of movement in the affected limb (109).Cognitive rehabilitation activities are designed to improve memory, attention, and problemsolving skills.Aerobic exercises and hydrotherapy are included to improve cardiovascular health and overall fitness (70).Music therapy can be beneficial for enhancing mood and cognitive functions (110).
Long-term psychological support is crucial for helping patients adjust to their new normal and maintain motivation for continued recovery (111).

Acute management and rehabilitation
In the critical phase immediately following a stroke, the imperative is to promptly implement rehabilitation initiatives tailored to address immediate needs and initiate the recovery process.This phase is characterized by a dual focus on immediate rehabilitation strategies and addressing acute medical requirements.Acute management in stroke rehabilitation refers to the immediate interventions and care provided after the initial medical stabilization of a stroke patient, typically within the first few days to weeks following the stroke.This phase is distinct from emergency medical care and focuses on beginning the rehabilitation process to optimize recovery and prevent complications (40).After the initial emergency treatment, which aims to stabilize the patient and address life-threatening issues, acute management begins to initiate the rehabilitation journey.The goal during this phase is to start therapies that can enhance neurological recovery, improve functional outcomes, and set the stage for longterm rehabilitation (112).This involves a multidisciplinary approach, including neurologists, physical therapists, occupational therapists, speech therapists, and other healthcare professionals working together to develop a comprehensive care plan (101).
Continuous monitoring of neurological status and vital signs is crucial for detecting any signs of deterioration or complications such as recurrent strokes, infections, or cardiac issues.Adjustments to medication regimens and treatments are made based on the patient's evolving condition (113).Initiating gentle physical activities and mobilization as soon as the patient is medically stable is essential.Early mobilization helps prevent complications like deep vein thrombosis, muscle atrophy, and joint contractures.Physical therapists work with patients to perform passive and active range of motion exercises, bed mobility exercises, and, when possible, supported standing and walking activities (114).Occupational therapists focus on helping patients regain their ability to perform daily activities.This includes exercises and interventions designed to improve motor skills, coordination, and cognitive functions necessary for tasks such as dressing, eating, and personal hygiene (115).For patients experiencing aphasia or dysphagia, speech therapists conduct assessments and provide targeted therapies to improve communication and swallowing abilities.This is critical to ensure that patients can safely consume food and liquids, thus reducing the risk of aspiration pneumonia (116).Addressing the psychological impact of a stroke is a key component of acute management.Mental health professionals provide counseling and support to help patients and their families cope with the emotional aftermath of a stroke.This support can help in reducing anxiety and depression, fostering a positive outlook towards rehabilitation (14).
Proactive measures are taken to prevent secondary complications, including managing risk factors for recurrent strokes, such as hypertension and diabetes, ensuring proper nutrition, and maintaining skin integrity to prevent pressure ulcers (117).Thus, The primary objectives of acute management in stroke rehabilitation are to stabilize the patient's medical condition, initiate rehabilitation therapies to enhance recovery, prevent secondary complications such as infections, thromboembolic events, and muscle wasting, provide psychological support to help patients and families adjust to the changes brought by the stroke, and establish a foundation for the subsequent stages of rehabilitation.By addressing these aspects, acute management aims to maximize the potential for functional recovery and improve the overall quality of life for stroke patients in the critical early days following their stroke.

Early rehabilitation initiatives
In the crucial hours immediately after a stroke, the introduction of early rehabilitation initiatives holds profound significance.These pivotal interventions, instated within the initial 24 to 48 h following the stroke event, form the cornerstone of the recovery process (118).Their primary objectives encompass preventing potential complications, initiating the rehabilitation trajectory, and laying the essential groundwork for optimal recovery (119).
Passive range-of-motion exercises emerge as fundamental components even during the acute phase post-stroke.These gentle movements administered to the affected limbs serve as a safeguard, preserving joint flexibility and thwarting the onset of muscle contractures.This preventive measure is instrumental in mitigating the risks associated with long-term impairments that could impede the recovery process (120,121).Early mobilization takes precedence as a pivotal strategy in acute rehabilitation.Encouraging and facilitating patients to engage in sitting exercises, standing movements, and, when feasible, undertaking short walks constitute early mobilization efforts (71).Beyond mitigating muscle deconditioning, these early mobilization initiatives significantly mitigate the likelihood of complications like deep vein thrombosis and pressure ulcers, essential for promoting a conducive environment for recovery (122,123).Sensory stimulation techniques, involving tactile, auditory, or visual stimulation, are employed to arouse and activate affected senses.This early engagement of the senses aims to jumpstart neural plasticity and sensory reawakening in the specific brain regions impacted by the stroke event (124,125).While seemingly straightforward, these early rehabilitation initiatives wield a profound impact.Their implementation is consistently validated by research, underscoring their pivotal role in shaping the trajectory of recovery for stroke survivors.

Addressing mobility and functional impairments
In the acute phase of stroke rehabilitation, the focus sharply narrows to addressing mobility and functional impairments.This critical phase aims to reestablish lost capabilities, enhance balance, coordination, and restore independence in daily activities (Figure 2).Physiotherapy interventions form the backbone of efforts to regain  (126,127).Occupational therapy takes center stage in reinstating functionality in ADLs.Occupational therapists guide patients through essential tasks, such as dressing, grooming, feeding, and home management.The focus lies in enabling patients to regain independence in these pivotal daily activities, promoting autonomy and self-sufficiency (128).Task-specific training, an integral component of acute rehabilitation, involves engaging patients in activities tailored precisely to their deficits.By replicating real-life situations, this method fosters neural reorganization and functional recovery.These activities, meticulously designed to confront the unique challenges posed by the stroke, play a pivotal role in retraining the brain and restoring lost functionalities (56,129).This acute phase of rehabilitation, deeply rooted in tailored interventions and guided exercises, serves as the foundation upon which subsequent recovery efforts are built.By addressing mobility and functional impairments strategically, this phase contributes significantly to restoring independence and enhancing the quality of life for stroke survivors (87).

Integrating rehabilitation into acute care
Integrating rehabilitation seamlessly into acute care settings is a fundamental aspect of providing comprehensive stroke care.This integration involves merging rehabilitation strategies into the acute medical management plan, ensuring a cohesive approach to address immediate medical needs alongside rehabilitation goals (130).Early identification and team collaboration are pivotal in this integration.Identifying rehabilitation needs promptly and assembling a multidisciplinary team comprising neurologists, physiatrists, nurses, therapists, and social workers facilitates a comprehensive assessment.This collaborative effort allows for a simultaneous evaluation of rehabilitation requirements in tandem with acute medical interventions (131).Tailoring rehabilitation goals forms the cornerstone of the integrated approach.Setting specific, measurable, achievable, relevant, and time-bound (SMART) objectives is crucial.These objectives, personalized to the patient's condition, aim to optimize functional recovery while concurrently addressing immediate medical concerns.This tailored framework for rehabilitation forms the bedrock of a responsive and dynamic rehabilitation plan (132).Continuous monitoring and adjustment of rehabilitation strategies are essential components of this integrated model.Continuous evaluation of the patient's response to rehabilitation interventions enables real-time adjustments.This adaptive approach ensures that rehabilitation strategies remain responsive to the patient's evolving needs and medical condition, fostering a flexible and patient-centric rehabilitation process (133,134).Integrating rehabilitation into acute care represents a paradigm shift, acknowledging the symbiotic relationship between immediate medical interventions and the imperative need for rehabilitative efforts.This holistic approach not only kickstarts the rehabilitation journey early on but also ensures a coordinated and comprehensive care plan for stroke survivors (19, 135).

Physical therapy
Physical therapy (PT) stands as a cornerstone within stroke rehabilitation, encompassing a multifaceted approach aimed at restoring mobility, enhancing motor function, and mitigating physical impairments.It serves as an integral component throughout the continuum of stroke care, spanning from acute management to longterm recovery (136,137).Upon initial assessment, physical therapists Different stroke rehabilitation modalities.(142,143).Therapists employ various balance exercises and proprioceptive activities to improve balance and coordination, essential for preventing falls and enabling functional mobility.These exercises often involve challenging the patient's stability in a controlled environment to enhance balance reactions and postural control (144).Moreover, to mitigate the risk of secondary complications such as joint contractures and stiffness, therapists incorporate range-of-motion exercises.These gentle movements aim to preserve joint flexibility, prevent musculoskeletal issues, and facilitate ease of movement in affected limbs (145,146).PT extends beyond clinical settings, encompassing functional training and home modification recommendations.Therapists collaborate with patients to simulate real-life scenarios, practicing activities crucial for daily living.Additionally, they provide guidance on adapting home environments and suggesting assistive devices and modifications to enhance accessibility and safety within the home setting (147,148).Physical Therapy, as a core element of stroke rehabilitation, not only targets physical impairments but also promotes functional independence, enabling individuals to regain confidence and improve their overall quality of life following a stroke.

Occupational therapy
Occupational therapy (OT) within stroke rehabilitation is a pivotal modality focused on restoring independence in daily activities, re-establishing functional abilities, and promoting engagement in meaningful life roles.Tailored to each individual's needs and goals, OT interventions span various domains to facilitate a smoother transition from impairment to autonomy (149, 150).Occupational therapists conduct comprehensive assessments to gauge the impact of stroke on an individual's ability to perform daily tasks.These assessments help formulate personalized rehabilitation plans, targeting specific deficits in ADLs, instrumental activities of daily living (IADLs), work-related tasks, and leisure activities (151,152).OT interventions primarily revolve around retraining and adapting ADLs.Therapists employ taskoriented training to facilitate independence in self-care activities such as grooming, bathing, dressing, toileting, and feeding.Adaptive strategies, environmental modifications, and the use of assistive devices are integrated to maximize functional independence and participation in daily routines (153,154).Recovery of upper limb function is a key focus within OT.Therapists utilize exercises targeting hand-eye coordination, fine motor control, and dexterity.Techniques like constraint-induced movement therapy (CIMT), mirror therapy, and graded motor imagery are employed to encourage the use of the affected limb and improve its function (155).OT extends its scope to support community reintegration and vocational pursuits.Therapists assist individuals in transitioning back into community life by providing guidance on accessing community resources, public transportation, and social participation.Vocational rehabilitation focuses on adapting work environments, modifying job tasks, and exploring adaptive technologies to facilitate a return to work or engagement in meaningful productive activities (156,157).
Occupational therapists address cognitive impairments and sensory deficits that impact daily functioning.Strategies are implemented to improve attention, memory, executive functions, and problem-solving skills necessary for effective task performance.Sensory integration techniques help individuals process sensory information effectively, enhancing their ability to engage in meaningful activities (158).Collaborating with individuals and their families, OTs recommend modifications in the home environment to promote safety, accessibility, and independence.Suggestions for adaptive equipment and assistive devices are provided to facilitate ease in performing tasks and to compensate for functional limitations (159).OT, as an integral part of stroke rehabilitation, focuses on enabling individuals to regain independence and participation in activities essential to their daily lives, fostering a sense of accomplishment and self-sufficiency post-stroke.

Speech and language therapy
Speech and language therapy (SLT) is a critical component of stroke rehabilitation, encompassing a diverse range of interventions tailored to address communication and swallowing difficulties.These interventions aim to restore functional communication abilities and ensure safe swallowing, significantly impacting an individual's quality of life post-stroke (39).Speech-language pathologists conduct comprehensive assessments to evaluate the extent of communication impairments and swallowing difficulties post-stroke.These assessments form the basis for individualized treatment plans that address specific deficits and goals (160).SLT interventions for speech articulation aim to improve clarity, intelligibility, and pronunciation.Therapists utilize exercises targeting oral-motor coordination, breath control, and vocal exercises to enhance speech production (161).Techniques such as articulation drills, repetition exercises, and tongue-strengthening exercises aid in improving speech intelligibility (162).Language therapy focuses on improving language comprehension and expression abilities.Therapists employ activities like word-finding exercises, storytelling, and comprehension tasks to enhance language skills.Strategies aim to rebuild vocabulary, sentence construction, and overall language fluency (163).
SLT addresses cognitive-communication deficits resulting from stroke, including impairments in problem-solving, reasoning, and social communication skills.Therapists use tasks such as conversation practice, problem-solving scenarios, and pragmatic language exercises to improve overall communication abilities

Cognitive rehabilitation
Cognitive rehabilitation plays a vital role in stroke recovery, focusing on addressing cognitive impairments such as memory deficits, attention issues, and executive function difficulties.This multifaceted approach aims to restore and enhance cognitive abilities, ultimately promoting independence and improving the individual's quality of life post-stroke (170).Cognitive rehabilitation begins with a comprehensive assessment of cognitive functions post-stroke.Therapists evaluate memory, attention, problem-solving, and executive function to identify specific deficits.Based on this assessment, tailored interventions are designed to address individual needs (88).Therapists employ various memory-enhancing techniques to improve memory recall and retention.These strategies may include mnemonic techniques, spaced-repetition exercises, memory games, and the use of memory aids like calendars or notebooks.By practicing memory recall, individuals can strengthen their ability to retain and retrieve information (171,172).Interventions targeting attention deficits involve exercises that aim to improve different aspects of attention, including sustained attention, selective attention, and divided attention (173).Therapists utilize tasks requiring sustained focus, attentional drills, and multitasking activities to enhance attentional abilities and reduce distractibility (174).Cognitive rehabilitation addresses deficits in executive functions such as planning, problem-solving, and decision-making.Therapists employ tasks that require organization, time management, and prioritization to enhance cognitive flexibility and executive control.Strategies focus on breaking tasks into manageable steps and implementing problemsolving techniques (175).For individuals experiencing cognitivecommunication deficits, therapists introduce strategies that enhance communication effectiveness.Techniques may involve using visual aids, simplifying information, and employing structured communication methods to aid comprehension and expression (176).Interventions extend to practicing functional tasks relevant to daily life.Therapists guide individuals through activities that replicate realworld scenarios, such as meal planning, managing finances, or using public transportation.Task-specific training helps individuals adapt to challenges they might encounter in their daily routines (177).Therapists collaborate with individuals to develop compensatory strategies and routines to cope with cognitive deficits.Additionally, recommendations for environmental modifications, such as organizing living spaces or implementing memory aids, assist individuals in managing daily tasks more effectively (178).Cognitive rehabilitation within stroke rehabilitation focuses on empowering individuals to adapt and compensate for cognitive impairments, enhancing their ability to perform daily activities independently and facilitating a smoother reintegration into their daily routines post-stroke.

Integration of proprioceptive training, dual-task exercises, and goal-oriented activities in stroke rehabilitation
Stroke rehabilitation aims to restore balance and autonomy in ADL through a variety of targeted exercises.Proprioceptive training, which focuses on improving body position awareness, is crucial for enhancing balance and coordination.Techniques such as balance boards, stability exercises, and sensory re-education are employed to stimulate proprioceptive feedback, promoting better motor control and reducing fall risk (105).
Dual-task exercises, which require patients to perform a motor task while simultaneously engaging in a cognitive task, have shown significant benefits in stroke recovery.These exercises not only improve physical function but also enhance cognitive processing, which is often impaired in stroke survivors.For instance, walking while counting backward or performing a physical task while responding to questions helps integrate cognitive and motor skills, leading to improved overall function (179,180).
Goal-oriented exercises involve setting specific, measurable, achievable, relevant, and time-bound (SMART) goals that align with the patient's individual needs and capabilities.These exercises foster motivation and adherence to the rehabilitation program (181).By focusing on personal goals, such as dressing independently or walking a certain distance, patients are more likely to stay engaged and Incorporating proprioceptive training, dual-task exercises, and goal-oriented exercises into stroke rehabilitation programs offers a comprehensive approach to improving balance and autonomy in ADL.Proprioceptive training enhances sensory feedback and coordination, dual-task exercises improve multitasking abilities and overall functional performance, and goal-oriented exercises ensure that rehabilitation is relevant and motivating for the patient.Together, these interventions address both the physical and cognitive challenges faced by stroke survivors, leading to more effective rehabilitation outcomes.Future research should continue to explore the optimal strategies for integrating these approaches to maximize their benefits for stroke patients.

Botulinum toxin injection in post-stroke spasticity
Spasticity resulting from strokes poses considerable hurdles to motor function and daily tasks for those affected.Botulinum toxin type A (BoNT-A) injection has become the preferred treatment for localized spasticity, especially among stroke survivors, owing to its established effectiveness, reversible nature, and minimal risk of complications.The treatment of upper motor neuron syndrome, marked by spasticity and excessive muscle activity, requires strategies to alleviate spasticity-related issues and forestall further complications (183).BoNT-A treatment has become a crucial therapeutic approach, especially for localized spasticity in individuals who have had strokes.Research exploring the effectiveness of elevated doses of BoNT-A (exceeding usual guidelines) in post-stroke spasticity has shown encouraging outcomes (184).Despite initial worries about potential systemic side effects, most patients encountered substantial decreases in spasticity without encountering severe issues (185,186).Although elevated doses of BoNT-A demonstrated effectiveness in spasticity reduction, instances of adverse effects, including contralateral weakness and systemic complications, were observed in certain cases (187).It is essential to carefully assess injection frequency, dilution volumes, and the possibility of antibody formation to minimize the likelihood of adverse events (188).The results highlight the efficacy of elevated doses of BoNT-A in managing post-stroke spasticity, especially in scenarios involving significant muscle hypertonia (189).Nonetheless, meticulous patient selection, accurate injection methodologies, and vigilant monitoring for adverse effects are crucial to enhancing treatment efficacy and upholding patient well-being.Research findings indicate the potential benefits of increased BoNT-A doses in mitigating spasticity and enhancing functional recovery among stroke survivors (190).Additional investigations are needed to clarify the most effective dosing regimens, improve injection methodologies, and assess the long-term safety and effectiveness in broader patient populations.

Technological advances in rehabilitation
Advancements in technology have revolutionized stroke rehabilitation, and one prominent innovation is the integration of robotics.Robotic-assisted rehabilitation systems offer a promising avenue to enhance motor recovery, functional outcomes, and patient engagement in stroke rehabilitation.

Robotics in stroke rehabilitation
Technological advancements, particularly in robotics, have dramatically transformed the landscape of stroke rehabilitation, ushering in innovative approaches to enhance motor recovery, functional abilities, and overall quality of life for individuals affected by stroke (191).In upper limb rehabilitation, robotics play a pivotal role by offering precise and intensive therapy through devices like exoskeletons and end-effector robots.These devices provide tailored exercises, guiding patients through movements aimed at improving motor control, strength, and the range of motion in affected arms and hands.This focused approach allows therapists to customize rehabilitation plans based on specific impairments, fostering more targeted and impactful interventions (192,193).Gait training, crucial for restoring walking abilities post-stroke, benefits significantly from robotic systems.Exoskeletons and treadmill-based robots assist individuals by providing mechanical support and guidance during walking exercises (194).These devices help in relearning proper gait patterns, correcting asymmetries, and improving balance and stride length.The real-time feedback offered by these systems enhances motor learning, aiding in the retraining of gait patterns (195).One of the significant advantages of robotic-assisted therapy lies in its ability to offer task-specific training.Therapists can replicate real-life activities through these systems, allowing stroke survivors to practice movements required for daily tasks.This tailored approach fosters neuroplasticity, encouraging the brain to adapt and rewire neural connections to facilitate improved movement patterns (196).
Additionally, these robotic systems provide therapists with realtime feedback and monitoring capabilities.They track performance metrics such as range of motion, force exertion, and movement accuracy.This data empowers therapists to assess progress accurately, modify therapy intensity, and customize treatment plans according to individual responses, ensuring optimized rehabilitation outcomes (197).The advent of portable and user-friendly robotic devices has extended the reach of rehabilitation beyond clinical settings.Homebased rehabilitation using these systems enables stroke survivors to continue their therapy under professional guidance.This continuity in therapy enhances accessibility and adherence to treatment, contributing to sustained recovery (198).Furthermore, the integration of adaptive algorithms powered by machine learning and artificial intelligence tailors rehabilitation interventions to individual needs.These algorithms analyze patient responses in real-time, allowing for adjustments in therapy parameters to maximize the effectiveness of rehabilitation protocols (199).
The interactive nature of robotic technologies in stroke rehabilitation engages patients through gamified exercises and interactive interfaces.This enhanced engagement motivates individuals to actively participate in therapy sessions, promoting adherence and ultimately contributing to improved outcomes and functional recovery (200).However, it is essential to acknowledge certain limitations associated with the use of robotics in rehabilitation.While robotics offer precise and intensive therapy, some challenges need to be addressed.One such limitation is the cost involved in acquiring and maintaining robotic systems, which may pose financial barriers to widespread adoption.Moreover, in certain usage protocols, such as assistive modes, there is a risk of decreased effort or attention from patients during training sessions.This decrease in engagement could potentially impact the effectiveness of rehabilitation outcomes.Therefore, it is crucial for therapists to carefully monitor patient participation and motivation levels during robotic-assisted therapy to ensure optimal results (201)(202)(203)(204). Despite these challenges, the benefits of robotic systems in stroke rehabilitation are considerable.Overall, while acknowledging the limitations, robotics in stroke rehabilitation represent a promising frontier in enhancing motor recovery and functional independence.These advancements pave the way for more personalized, engaging, and effective interventions, offering hope for improved rehabilitation outcomes for stroke survivors.

Virtual reality and augmented reality applications
Technological advancements in virtual reality (VR) and augmented reality (AR) have profoundly impacted the landscape of stroke rehabilitation, offering immersive, interactive, and personalized interventions that significantly contribute to the recovery process (205).
Within stroke rehabilitation, VR therapy creates computergenerated environments that simulate real-life scenarios.These environments immerse patients in interactive exercises tailored to their specific rehabilitation needs.VR-based tasks focus on improving motor functions, cognitive abilities, and balance (206).For instance, individuals can engage in upper limb exercises or practice balancerelated activities within a controlled virtual setting.By replicating realworld scenarios, VR therapy stimulates neuroplasticity and motor learning, aiding in functional recovery (207).
Augmented reality (AR) enhances rehabilitation by overlaying digital information onto the real world.AR applications provide realtime visual cues or instructions during exercises, aiding stroke survivors in performing movements accurately and safely (208).For example, a stroke survivor practicing arm movements may receive visual guidance overlaid onto their affected limb, promoting correct positioning and motion execution.AR enhances spatial awareness and motor planning, facilitating better task performance (209).
In cognitive rehabilitation, VR and AR interventions extend beyond physical movements to address deficits in attention, memory, and executive function.Gamified tasks and simulations challenge cognitive skills, stimulating neural adaptation and functional improvement (210).These technologies offer engaging and interactive cognitive exercises, fostering mental stimulation and promoting cognitive recovery post-stroke (211).Moreover, VR and AR applications allow stroke survivors to simulate functional tasks in a controlled virtual environment.Patients can practice activities such as cooking, shopping, or navigating public spaces within the safety of a virtual setting.These simulations offer a platform for individuals to relearn and regain confidence in performing daily tasks, preparing them for real-life scenarios and promoting independence (212, 213).
However, it is crucial to recognize that the applicability of VR therapy may vary among stroke survivors.Factors such as cognitive abilities, physical impairments, and individual preferences need to be considered when determining the suitability of VR interventions for a particular patient.While VR therapy holds tremendous potential for many individuals, it may not be suitable for everyone.Therefore, a comprehensive assessment on a case-by-case basis is essential to ensure that VR therapy is appropriately tailored to meet the unique needs and capabilities of each stroke survivor (214,215).
Despite the need for individualized assessment, VR and AR applications have demonstrated significant potential to enhance motivation and engagement during rehabilitation sessions.The immersive nature of these interventions captures individuals' attention, encouraging active participation in therapy.The interactive and enjoyable aspects of VR and AR contribute to increased adherence and consistency in rehabilitation exercises, positively impacting recovery outcomes.Overall, while recognizing the transformative impact of VR and AR technologies on stroke rehabilitation, it is essential to assess their applicability on a case-by-case basis.By conducting individualized assessments and tailoring interventions to meet the unique needs of each patient, therapists can maximize the effectiveness of VR and AR applications in promoting motor, cognitive, and functional recovery for stroke survivors (56,216,217).

Neurostimulation techniques
Technological advancements in neurostimulation techniques have emerged as promising interventions within the realm of stroke rehabilitation, seeking to modulate neural activity, induce neuroplastic changes, and ultimately enhance recovery outcomes for individuals impacted by stroke.

Transcranial magnetic stimulation
Transcranial magnetic stimulation (TMS) stands as a non-invasive neurostimulation technique used in stroke rehabilitation to modulate cortical excitability.It involves generating brief magnetic pulses through a coil placed over specific areas of the scalp, creating an electromagnetic field that penetrates the skull and influences neural activity in the underlying brain regions (218,219).In stroke rehabilitation, repetitive TMS (rTMS) aims to induce changes in cortical excitability by delivering repeated magnetic pulses to targeted brain areas associated with motor function.By adjusting the frequency, intensity, and duration of these pulses, clinicians can modulate neural activity and promote neuroplasticity (220).The primary goal of TMS in stroke recovery is to facilitate motor relearning and functional improvement in affected limbs.By targeting specific cortical regions related to motor control and movement execution, rTMS aims to promote neural reorganization, facilitating the formation of new neural connections or enhancing existing ones.This process supports motor learning and reacquisition of motor skills affected by strokeinduced impairments (221,222).Moreover, TMS is utilized to assess and map cortical excitability and the integrity of motor pathways in stroke survivors.By evaluating the response of motor cortices to TMS pulses, clinicians gain insights into the extent of cortical reorganization, helping to tailor and optimize rehabilitation strategies for individual patients (223).TMS holds promise as an adjunctive therapy in stroke rehabilitation, potentially enhancing outcomes by promoting neuroplastic changes, aiding in motor recovery, and improving functional abilities in affected individuals.Continued research and refinement of TMS protocols offer significant potential for optimizing its application in stroke rehabilitation, contributing to improved recovery and quality of life for stroke survivors.

Transcranial direct current stimulation
Transcranial direct current stimulation (tDCS) is a non-invasive neurostimulation technique used in stroke rehabilitation to modulate cortical excitability.It involves delivering low-intensity electrical currents via electrodes placed on the scalp, aiming to influence neuronal activity in targeted brain areas (224).In the context of stroke recovery, tDCS seeks to promote neuroplastic changes by modulating cortical excitability in regions affected by the stroke-induced impairments (225).By applying a continuous low electrical current to specific cortical areas, tDCS aims to either enhance or inhibit neuronal firing patterns, ultimately influencing the brain's ability to reorganize and adapt (226).The primary objective of tDCS in stroke rehabilitation is to facilitate neuroplasticity and enhance motor recovery.By modulating cortical excitability in motor-related brain regions, tDCS aims to promote the reorganization of neural networks, aiding in motor relearning and the restoration of motor function in affected limbs (227).Additionally, tDCS protocols can vary, employing different electrode montages and stimulation parameters to target specific cortical areas associated with motor function.The modulation of cortical excitability using tDCS may facilitate motor learning processes and the reacquisition of motor skills impacted by strokerelated impairments (228).Moreover, tDCS is considered a safe and well-tolerated technique, often used in conjunction with other rehabilitation approaches.Its non-invasive nature and potential to induce neuroplastic changes make it an attractive adjunctive therapy in stroke rehabilitation (229).Continued research into optimal tDCS parameters, such as electrode placement, stimulation duration, and intensity, holds promise for refining its application in stroke recovery.As the understanding of tDCS mechanisms grows, it offers substantial potential to enhance motor recovery outcomes and improve functional abilities in stroke survivors.

Functional electrical stimulation
Functional electrical stimulation (FES) is a rehabilitative technique employed in stroke rehabilitation to activate paralyzed or weakened muscles by delivering controlled electrical impulses to peripheral nerves or muscle groups.It aims to restore voluntary movement, improve muscle strength, and facilitate motor relearning in affected limbs (229).In stroke survivors experiencing motor impairments, FES utilizes electrodes placed on the skin's surface or implanted directly on muscles to deliver electrical stimulation (230).This stimulation generates muscle contractions, facilitating movements that may be difficult or impossible due to stroke-induced paralysis or weakness (231).The primary goal of FES in stroke rehabilitation is to support motor recovery and functional improvement.By stimulating targeted muscles or muscle groups, FES assists in muscle strengthening, preventing muscle atrophy, and enhancing muscle performance.This electrical stimulation aids in restoring voluntary movement patterns, facilitating motor control, and promoting the relearning of motor skills necessary for activities of daily living (232).FES applications can vary based on the specific rehabilitation goals and affected muscle groups.For instance, in upper limb rehabilitation, FES may target muscles involved in hand grasping or arm movement, aiding in functional tasks such as reaching or grasping objects.In lower limb rehabilitation, FES can assist with walking by stimulating leg muscles to facilitate stepping movements (233).
Furthermore, FES can be integrated into functional tasks or exercises, enabling stroke survivors to actively engage in movements with the assistance of electrical stimulation.This integration of FES with rehabilitation exercises promotes motor learning, supports taskspecific training, and enhances functional recovery (234).
However, it is important to acknowledge that various studies have reported concerns regarding the discomfort associated with wearing FES instruments for prolonged periods.Additionally, prolonged FES usage may lead to muscle fatigue and decrease responsiveness, potentially affecting its effectiveness in stroke rehabilitation.Muscle fatigue presents a significant challenge associated with FES, imposing limitations on therapy duration and compromising its potential benefits (235).Furthermore, the effectiveness of conventional waveform modalities varies.These conventional waveforms lack guidance from neural movement control mechanisms, potentially reducing their efficacy in restoring movement (236,237).Despite these concerns, strategies can be implemented to mitigate these drawbacks.For instance, proper electrode placement and adjustment of stimulation parameters can help optimize comfort and minimize muscle fatigue.Moreover, incorporating regular breaks during FES sessions and integrating FES with other rehabilitation modalities can help prevent overuse-related issues and enhance overall treatment outcomes.Recently, there has been interest in utilizing muscle synergy-driven FES waveforms, which have demonstrated effectiveness in restoring muscle function among stroke patients (238).
Furthermore, FES can be integrated into functional tasks or exercises, enabling stroke survivors to actively engage in movements with the assistance of electrical stimulation.This integration of FES with rehabilitation exercises promotes motor learning, supports taskspecific training, and enhances functional recovery (234).The use of FES in stroke rehabilitation is well-established and considered a safe and effective adjunctive therapy.It complements other rehabilitation strategies, contributing to comprehensive treatment plans aimed at improving motor function and restoring independence in daily activities (239).Continued advancements in FES technology and its integration with other rehabilitation approaches hold significant promise for optimizing motor recovery outcomes, enhancing functional abilities, and improving the quality of life for individuals affected by stroke.

Implantable devices (brain-computer interfaces)
Brain-computer interfaces (BCIs) represent cutting-edge implantable devices used in stroke rehabilitation to establish a direct communication link between the brain and external devices, aiming to restore motor function and enhance functional independence (240).In the context of stroke recovery, BCIs decode neural signals from the brain, allowing individuals to control external devices or prosthetics directly through their thoughts (241).This technology bypasses damaged neural pathways, enabling stroke survivors with severe motor impairments to interact with their environment or perform tasks that were previously compromised due to strokeinduced limitations (242).BCIs typically involve surgically implanting electrodes or sensors directly into the brain's motor cortex or on the surface of the brain.These electrodes detect neural signals related to motor intentions or commands (243,244).Through advanced  (245).The primary objective of BCIs in stroke rehabilitation is to restore motor function and improve independence in individuals with severe motor impairments (246).By interpreting neural signals and translating them into control commands for external devices, BCIs enable individuals to execute movements or interact with their environment based on their intention, bypassing the physical limitations caused by stroke-induced motor deficits (245).BCIs hold immense potential in stroke recovery by providing individuals with a means to regain control over their movements and perform tasks that were previously challenging or impossible (245).This technology aims to enhance functional abilities, promote independence in daily activities, and improve the overall quality of life for stroke survivors with severe motor impairments.Ongoing developments in BCI technology, such as improving signal accuracy, enhancing decoding algorithms, and refining implantation techniques, offer promising prospects for further optimizing their application in stroke rehabilitation.As research progresses, BCIs hold substantial promise for revolutionizing rehabilitation practices and empowering stroke survivors to regain functional abilities and independence.
8 Challenges and opportunities in stroke rehabilitation

Lack of standardized timing for stroke rehabilitation initiation
One of the challenges in stroke rehabilitation is the absence of standardized guidelines for the timing of initiating rehabilitation programs.The timing of rehabilitation can significantly influence recovery outcomes, yet there is considerable variability in clinical practice regarding when to start specific rehabilitation interventions.
The initiation of rehabilitation can vary based on several factors, including the type of stroke, the severity of the stroke, patient comorbidities, and the specific rehabilitation protocols being used.Some rehabilitation programs advocate for early initiation, typically within the first few days after a stroke, while others may recommend waiting until the patient is more medically stable.Early rehabilitation, which often begins within the first 24 to 48 h after stroke onset, aims to capitalize on the brain's heightened plasticity during the acute phase.This approach can help prevent complications such as muscle atrophy and joint contractures and can improve functional outcomes (101).However, it requires careful monitoring to avoid overexertion and other risks.In contrast, some protocols suggest delaying the start of intensive rehabilitation until the subacute phase, typically 1 to 2 weeks post-stroke.This delay allows for better medical stabilization and assessment of the patient's overall condition (247).Furthermore, the lack of standardized timing affects various rehabilitation programs differently.Physical therapy and early mobilization are often encouraged, but the intensity and type of exercises may vary based on the patient's initial response and stability (123).The timing for starting occupational therapy can depend on the patient's ability to participate in ADLs and cognitive readiness (248).Moreover, the initiation of speech and language therapy may be contingent on the patient's neurological status and ability to engage in communication exercises (101).The variability in the initiation of rehabilitation programs underscores the need for standardized guidelines that can provide a framework for clinicians.Developing such guidelines would involve comprehensive research to determine the optimal timing for different rehabilitation interventions.Additionally, these guidelines should consider individual patient factors, such as age, comorbidities, and stroke severity.Collaboration among healthcare providers is also essential to establish a consensus on best practices.Thus, Addressing the lack of standardized timing for stroke rehabilitation initiation is crucial for improving patient outcomes.Establishing evidence-based guidelines can help ensure that patients receive timely and effective rehabilitation, tailored to their specific needs and conditions.Future research should focus on identifying the most effective timelines for various rehabilitation interventions to create a standardized approach that can be widely adopted in clinical practice.

Access to rehabilitation services
Access to comprehensive rehabilitation services remains a substantial challenge in stroke care.Geographical disparities, especially in rural or remote areas, often limit access to specialized rehabilitation centers and skilled healthcare professionals (249).Moreover, socioeconomic factors and financial constraints can impede access to rehabilitation, particularly for individuals with limited insurance coverage or financial resources (249).Addressing these challenges requires innovative approaches, such as telemedicine and mobile health solutions, to extend rehabilitation services beyond traditional clinical settings (250).Tele-rehabilitation programs, leveraging technology for remote assessment and therapy delivery, have shown promise in improving access to rehabilitation for underserved populations (251).Initiatives promoting communitybased rehabilitation and partnerships with local healthcare providers play a crucial role in bridging the access gap, and ensuring equitable delivery of stroke rehabilitation services (252).

Stroke-related infections during hospitalization
Stroke patients are particularly vulnerable to infections during their hospital stay due to a combination of factors such as immobility, impaired swallowing (dysphagia), weakened immune function, and the need for invasive procedures (253).These infections can significantly impact patient outcomes, prolong hospitalization, and increase healthcare costs.The most common infections encountered during hospitalization of stroke patients include pneumonia, urinary tract infections (UTIs), and bloodstream infections (254).
Pneumonia is one of the most frequent complications in stroke patients, particularly those with dysphagia, which is difficulty in swallowing.Aspiration pneumonia occurs when food, liquid, or saliva is inhaled into the lungs instead of being swallowed into the esophagus.This risk is heightened in patients who have had a stroke because the neurological impairment can affect the muscles involved in swallowing (255).Pneumonia in stroke patients can lead to severe respiratory issues and prolong recovery times (256).Preventative measures include early assessment and management of swallowing difficulties, the use of thickened liquids, and positioning strategies during feeding to reduce the risk of aspiration.Urinary tract infections (UTIs) are another common complication in stroke patients.Factors contributing to UTIs include the use of urinary catheters, which are often necessary due to incontinence or mobility issues post-stroke.Catheter-associated urinary tract infections (CAUTIs) are a significant concern because they can lead to more serious systemic infections, including sepsis (257).Preventing UTIs involves careful catheter care, minimizing catheter use, and removing catheters as soon as possible.Hydration, proper hygiene, and regular monitoring for signs of infection are also crucial.Bloodstream infections, including central line-associated bloodstream infections (CLABSIs), can occur in stroke patients, especially those who require intravenous therapy or other invasive procedures.These infections can escalate into sepsis, a lifethreatening response to infection, further complicating the patient's recovery (258).To prevent bloodstream infections, healthcare providers must adhere to strict aseptic techniques during the insertion and maintenance of central lines and other invasive devices.Regular monitoring and prompt treatment of any signs of infection are essential.
Preventing infections in stroke patients requires a comprehensive and proactive approach.Encouraging early movement and physical therapy to reduce the risks associated with prolonged immobility, such as pneumonia and pressure ulcers.Mobilization helps improve circulation and lung function, reducing the likelihood of infections (256).Performing timely evaluations of swallowing ability to identify patients at risk for aspiration pneumonia.Interventions might include dietary modifications, swallowing exercises, and the use of thickened liquids (255).Implementing protocols to ensure the proper use and maintenance of urinary catheters.This includes adhering to guidelines for catheter insertion, ensuring cleanliness, and removing catheters as soon as they are no longer necessary to reduce the risk of CAUTIs (257).Promoting stringent hand hygiene practices among healthcare providers and visitors to minimize the transmission of pathogens in the hospital environment (258).Using antibiotics judiciously to prevent the development of antibiotic-resistant bacteria and reduce the risk of adverse reactions.This involves selecting the appropriate antibiotic and duration of treatment based on the specific infection and patient condition (257).Infections are a significant risk for stroke patients during hospitalization, contributing to higher morbidity and mortality rates.By implementing targeted preventive measures and closely monitoring patients, healthcare providers can reduce the incidence of infections and improve overall outcomes.Effective infection control practices are essential to ensure the best possible recovery for stroke patients.

Tailoring rehabilitation to individual needs
The heterogeneity of stroke-related impairments and the diverse needs of stroke survivors pose challenges in tailoring rehabilitation interventions.Standardized approaches may not adequately address the unique complexities of everyone's recovery journey (47).Personalized rehabilitation plans that consider specific impairments, functional goals, cognitive abilities, and psychosocial factors are essential.Integrating advanced technologies, such as artificial intelligence (AI) and machine learning, into rehabilitation protocols enables the customization of interventions based on real-time patient data and responses (199,259).Wearable devices and sensor-based technologies provide objective measures, facilitating the monitoring of progress and the adaptation of rehabilitation strategies according to individual needs (260).Establishing a framework for personalized rehabilitation that combines clinical expertise with technological advancements holds significant potential in optimizing outcomes for stroke survivors.

Interdisciplinary collaboration and training
Effective stroke rehabilitation requires seamless collaboration among diverse healthcare professionals, each contributing specialized expertise.However, achieving interdisciplinary collaboration poses challenges in terms of communication, coordination, and shared decision-making among multidisciplinary teams (261).Enhancing collaboration necessitates specialized training programs that emphasize interdisciplinary skills, fostering a shared understanding of stroke rehabilitation across disciplines.Training initiatives that promote team-based care, communication strategies, and shared decision-making frameworks are pivotal in overcoming barriers to collaboration (262).Moreover, establishing interprofessional education programs during healthcare training cultivates a collaborative mindset among future healthcare providers.Encouraging interdisciplinary rounds, case conferences, and joint care planning sessions facilitate cohesive care delivery, optimizing rehabilitation outcomes for stroke survivors (262).
In navigating these challenges, there exist promising opportunities to revolutionize stroke rehabilitation.By addressing access disparities, individualizing care, and fostering interdisciplinary collaboration, the stroke rehabilitation landscape can evolve to provide more comprehensive, patient-centered, and effective care for stroke survivors.Continued innovation, research, and collaboration across healthcare sectors hold the potential to significantly enhance stroke rehabilitation outcomes in the future.9 Future directions in stroke rehabilitation

Personalized rehabilitation approaches
The future of stroke rehabilitation lies in advancing personalized approaches tailored to the specific needs and characteristics of each individual.Embracing innovative technologies, such as artificial intelligence and machine learning algorithms, holds immense promise in developing more sophisticated and adaptive rehabilitation protocols (19).These technologies can analyze vast datasets, including genomic, neuroimaging, and behavioral information, to create individualized treatment plans.Moreover, exploring the integration of virtual reality, augmented reality, and gamification strategies can further enhance engagement and motivation in personalized rehabilitation programs (263).The future direction emphasizes a shift towards precision medicine in stroke rehabilitation, catering treatments uniquely to each patient's biological, cognitive, and psychosocial profile.

Integrating neuroplasticity concepts
Understanding and leveraging neuroplasticity principles are at the forefront of future stroke rehabilitation strategies.Emphasizing interventions that harness the brain's inherent ability to reorganize and adapt following injury is crucial.Innovative therapeutic approaches, such as non-invasive brain stimulation techniques (e.g., transcranial magnetic stimulation, transcranial direct current stimulation), target neuroplastic changes in the brain (264).Additionally, combining traditional rehabilitation with novel strategies, such as enriched environments, sensory stimulation, and task-specific training, promotes neuroplasticity and enhances functional recovery.The future direction focuses on optimizing interventions that exploit neuroplasticity mechanisms to facilitate greater and more sustained recovery in stroke survivors.

Advancements in assistive technologies
The future landscape of stroke rehabilitation is intertwined with rapid advancements in assistive technologies aimed at augmenting functional abilities and improving independence.Cutting-edge innovations in robotics, exoskeletons, and wearable devices offer promising avenues to enhance motor recovery and support activities of daily living.Advancements in BCIs aim to seamlessly integrate with the brain's neural signals, allowing for more intuitive control of assistive devices (265).Moreover, developments in sensor technology and smart home systems enable a more connected and supportive environment for stroke survivors.The future direction underscores the integration of these assistive technologies into rehabilitation programs, aiming to empower stroke survivors, enhance their autonomy, and improve overall quality of life.These future directions herald a paradigm shift in stroke rehabilitation, focusing on individualization, neuroplasticity-driven approaches, and the integration of innovative assistive technologies.Continued research, collaboration, and technological advancements hold substantial promise in revolutionizing stroke rehabilitation practices, ultimately improving outcomes and quality of life for individuals affected by stroke.

Conclusion
In conclusion, stroke rehabilitation represents a dynamic and evolving field that demands multidimensional approaches to address the diverse needs of stroke survivors.Throughout this manuscript, we have traversed various aspects of stroke rehabilitation, acknowledging the critical role of early identification, personalized interventions, and interdisciplinary collaboration in optimizing outcomes.While challenges persist, including access barriers and the complexity of tailoring interventions, the future of stroke rehabilitation appears promising.Future directions emphasizing personalized approaches, leveraging neuroplasticity concepts, and integrating cutting-edge assistive technologies offer new horizons in stroke care.By harnessing these opportunities and continuing to innovate, the rehabilitation community can significantly enhance recovery outcomes, foster greater independence, and ultimately improve the lives of those affected by stroke.This manuscript serves as a roadmap for future research, policy development, and clinical practice, underscoring the imperative of advancing stroke rehabilitation to meet the evolving needs of stroke survivors globally.

TABLE 1
Efficacy of various rehabilitation approaches across different stages of stroke recovery.
Speech and language therapy (SLT)Enhances communication abilities, including speech, language, and swallowing functions; critical for improving social interactions and quality of life Acute to chronic (76-78) Functional electrical stimulation (FES) Improves muscle strength and motor control by applying electrical stimulation to paralyzed muscles, facilitating voluntary muscle contraction Acute to chronic (79-82) Mirror therapy Enhances motor recovery and reduces pain by creating a visual illusion of movement in the affected limb through mirror reflection Subacute to chronic (83-86) Cognitive rehabilitation Improves cognitive functions such as memory, attention, and problemsolving; essential for overall functional recovery and independence Subacute to chronic (87-90) Hydrotherapy Utilizes water resistance and buoyancy to improve strength, balance, and coordination; reduces pain and facilitates movement Subacute to chronic (91, 92) Music therapy Enhances mood, motivation, and motor function through rhythmic and musical cues; supports emotional well-being and recovery Acute to chronic (93-95) Psychological counseling and support Addresses emotional and mental health issues, including depression and anxiety, which are common post-stroke; improves overall well-being (141)139)sly evaluate the individual's functional abilities, motor impairments, and specific limitations resulting from the stroke.Based on this assessment, personalized rehabilitation plans are crafted, and tailored to address the unique needs and goals of each patient.These plans are dynamic, evolving with the patient's progress and changing requirements(138,139).Gait training assumes a crucial role in PT for stroke survivors, focusing on restoring and optimizing walking patterns.Therapists employ various techniques, from treadmill-based training to over-ground walking practice, concentrating on improving balance, strength, and coordination (140).Advanced technologies such as robotic-assisted gait training or body-weight-supported treadmill training may be utilized to augment the rehabilitation process.Emphasis is placed on re-establishing a safe and functional gait to enable increased independence in daily activities(141).PT interventions encompass a range of exercises designed to enhance muscle strength, flexibility, and coordination.Targeted exercises, customized to address specific muscle groups affected by the stroke, aid in motor recovery.Therapists utilize resistance training, functional activities, and neuromuscular re-education to promote muscle activation and facilitate movement in impaired limbs (165)owing difficulties, known as dysphagia, are common post-stroke.SLT interventions target these issues to ensure safe and efficient swallowing.Therapists employ various exercises to improve muscle coordination and swallowing reflexes(165).