Engineering the Thermal Conductivity of Doped SiGe by Mass Variance: A First-Principles Proof of Concept

Thermal conductivity of bulk Si0.5 Ge0.5 at room temperature has been calculated using density functional perturbation theory and the phonon Boltzmann transport equation. Within the virtual crystal approximation, second- and third-order interatomic force constants have been calculated to obtain anharmonic phonon scattering terms. An additional scattering term is introduced to account for mass disorder in the alloy. In the same way, mass disorder resulting from n- and p-type dopants with different concentrations has been included, considering doping with III-group elements (p-type) such as B, Al, and Ga, and with V-group elements (n-type) such as N, P, and As. Little effect on the thermal conductivity is observed for all dopants with a concentration below 1021 cm−3. At higher concentration, reduction by up to 50% is instead observed with B-doping in agreement with the highest mass variance. Interestingly, the thermal conductivity even increases with respect to the pristine value for dopants Ga and As. This results from a decrease in the mass variance in the doped alloy, which can be considered a ternary system. Results are compared to the analogous effect on the thermal conductivity in doped Si.


INTRODUCTION
A detailed understanding of the mechanisms ruling over thermal transport is of great importance for many technological applications. In microelectronics, for example, fast dissipation of heat is desired (Cahill et al., 2003), translating into a high thermal conductivity. On the other hand, low thermal conductivity is sought for in thermoelectric devices which are of great environmental interest for their ability to transform waste heat into electrical energy. A lower thermal conductivity results in an increased figure of merit, which is the key indicator for the efficiency of heat-to-current conversion (Dresselhaus et al., 2007;Snyder and Toberer, 2008;Hahn et al., 2021).
In fact, a common strategy to optimize the performance of such materials is the reduction of their thermal conductivity while keeping the electrical conductivity mostly unaffected (Snyder and Toberer, 2008;Yu et al., 2010). A promising approach in this respect is nanostructuration (Minnich et al., 2009;He, Donadio, and Galli, 2011;Ferre Llin et al., 2013;Savic et al., 2013). Another efficient way to reduce the thermal conductivity is through introduction of mass disorder, which can be achieved by alloying as successfully shown, for example, in SiGe materials (Steele and Rosi, 1958;Abeles, 1963;Garg et al., 2011;Melis and Colombo, 2014). Already at a Ge content as low as 3%, the thermal conductivity is reduced by a remarkable 84% with respect to pure Si (Garg et al., 2011).
In a similar way, doping of semiconducting materials (essential in most technological applications) introduces mass disorder and can lead to a reduced thermal conductivity. Besides mass disorder, the addition of dopants deeply affects the crystalline state in many respects, including the variation of chemical bonds, the charge distribution, and a possible alteration of the electronic band structure. Different methods have been proposed recently to address such phenomena within the framework of first-principles calculations (Lindsay et al., 2019;McGaughey et al., 2019) and their effect on the thermal conductivity (Liao et al., 2015;Wang et al., 2016).
Recent progress in theoretical methods gave rise to a detailed description of various scattering mechanisms affecting the thermal conductivity in doped materials. However, it is almost impossible to verify single scattering contributions on an experimental level. It is therefore of great interest to elaborate each scattering mechanism as detailed as possible while keeping in mind all other possible scattering mechanisms when comparing theoretical results to experimental data. This state of affairs defines the scenario in which this investigation is framed in.
A first important issue to consider when addressing thermal transport in doped materials is the phonon-electron interaction. It can be invoked using Fermi's golden rule for phonon-electron scattering (Ziman, 1960). In semiconductors, however, carrier concentrations are typically low with respect to metals, and the effect of phonon-electron interaction on the thermal conductivity can be neglected to a good extent (Liao et al., 2015;Wang et al., 2016).
Next, structural and chemical differences resulting in a change of the interatomic force constants (IFC) can be described using Green's function method based on the construction of the T-matrix (Mingo et al., 2010;Polanco and Lindsay, 2018). The T-matrix is derived from Green's function and the perturbation to the dynamical matrix of the defect-free system caused by the system with defect. In the dilute limit, the scattering from such perturbation in the IFC force constants linearly depends on the number of defects.
Several studies have addressed the contributions of different effects. It has been shown, for example, that acoustic phonons in doped InN are represented well considering only mass disorder as the perturbing scattering mechanism for almost all dopants, except for As substitution of N, having the highest mass variance (Polanco and Lindsay, 2018). For optical phonon scattering rates, perturbation of the IFC, however, adds a relevant contribution. Unfortunately, verification with experimental data has not been provided. Another study provided evidence that the IFC disorder is essential in alloys consisting of III-V or II-VI group elements, while thermal transport in IV-group alloys, such as Si 1-x Ge x , is described well taking into account only mass disorder (Arrigoni et al., 2018). Recently, the effect of phonon-electron interaction on the thermal conductivity in Si 1-x Ge x has been analyzed, showing a notable effect for carrier concentration above 10 19 cm −3 (Xu et al., 2019). However, mass disorder from the dopant species has not been considered.
The effect of mass disorder was evaluated in multicomponent semiconductors where phonon spectrum and thermal conductivity have been calculated for ZnS, CuGaS 2 , and Cu 2 ZnGeSn 4 (Shibuya et al., 2016). Zn isotopes were introduced in ZnS resembling the mass disorder of the other materials, that is, Cu + Ga and Cu 2 +Zn + Ge. A direct comparison to the real systems, however, is difficult, since the crystal structure and chemical composition of ZnS and the respective ternary and quaternary systems are different.
First-principles calculations were used as well to analyze the effect of Na-and Ga-doping in CaMnO 3 by explicitly introducing the dopants into a supercell, resulting in a dopant concentration of 2.5% (Zhang et al., 2011). The thermal conductivity was approximated from the mean free path based on the Debye temperature, neglecting anharmonic phonon scattering. This, however, has been shown to be critical for systems with components of different masses. A comparative study of the thermal properties in GaN confronting the latter approach with a fitted parameter for anharmonic scattering with the explicit calculation of three-phonon scattering events based on the third-order IFC revealed the importance of optical phonons in scattering processes which are poorly captured using a fitted parameter for anharmonic scattering (Albar and Donmezer, 2020).
While previous studies have often focused on IFC disorder and phonon-electron scattering for the determination of thermal transport, less attention has been paid to the effect of mass disorder induced by doping with different materials. Therefore, here, we focus on scattering events resulting from different mass variances and their effect on the lattice thermal conductivity in the Si 0.5 Ge 0.5 alloy, which is of technological interest for thermoelectric applications. Several dopants of group III and V elements have been considered, including B, N, Al, P, Ga, and As, and their concentration has been changed from 10 19 to 10 22 cm −3 . Results have been compared to the same kind of doping in bulk Si.

THEORETICAL FRAMEWORK
The phonon transport processes have been evaluated by density functional (perturbation) theory (DF(P)T) calculations as implemented in the D3Q plug-in of the QUANTUM ESPRESSO program package (Giannozzi et al., 2009). In this approach, third-order force constants are calculated applying the "2n+1" theorem (Debernardi and Baroni, 1994;Debernardi et al., 1995), which basically states that the "2n+1"-th order variation of the total energy can be obtained from the nth order variation of the charge density. Knowledge of the third-order force constants allows for the determination of three phonon scattering processes and eventually the calculation of thermal conductivity (Ziman, 1960;Fugallo et al., 2013;Paulatto et al., 2013) given by where c α,β q j are the α-th and β-th Cartesian components of group velocities of phonons in the q j branch, Ω is the unit cell volume, k B is the Boltzmann constant, and ω q j , n q j , and τ q j are the vibrational frequencies, the Bose-Einstein occupation, and the relaxation time, respectively, of the qj phonon mode.
Frontiers in Mechanical Engineering | www.frontiersin.org July 2021 | Volume 7 | Article 712989 Group velocities and vibrational frequencies are obtained from the dynamical matrix, whose entries are the second-order interatomic force constants. Without the contribution of scattering events that are captured in the relaxation time τ q j , the thermal conductivity would reach infinite values.
Here, the single-mode relaxation time approximation (SMA) has been applied to account for scattering rates due to anharmonicity. At temperatures >100 K, Umklapp processes dominate the phonon scattering which justifies the use of the SMA. The thermal conductivity in Si 0.5 Ge 0.5 at 300 K has been calculated as well using the exact solution (variational approach) (Fugallo et al., 2013), showing no notable difference with respect to the SMA results. Within the relaxation time approximation, scattering rates P i are summed by Matthiesen's rule as follows: where the label i runs over all possible scattering mechanisms. In this work, we consider both the material intrinsic scattering due to anharmonicity of lattice vibrations and scattering from mass disorder. The anharmonic scattering rate, resulting from threephonon events, is described by Paulatto et al. (2013): where N 0 is the number of q points on a uniform mesh of the first Brillouin zone and V (3) qj,q ′ j ′ ,q ″ j ″ represents the anharmonic scattering coefficients of the three interacting phonon states q j, q′j′, and q″j″ (Lazzeri et al., 2003;Fugallo et al., 2013;Paulatto et al., 2013;Fugallo et al., 2014;Cepellotti et al., 2015). It is calculated as follows: where E tot is the total energy per unit cell and the quantity X q,j is defined as follows: where M s is the atomic mass of atom s, z sα * qj are the orthogonal phonon eigen modes normalized on the unit cell with the Cartesian coordinate α, and u sα (R l ) is the atomic displacement in the crystal cell identified by the lattice vector R l (Fugallo et al., 2013). In this approach, the δ function for the energy conversion which enters in the scattering rates provided in Eq. 3 is replaced by a Gaussian: with σ 2 g being the variance. For a realistic description of the lattice thermal conductivity of SiGe alloys, an additional scattering term resulting from mass disorder needs to be considered. This scattering term was first introduced by Tamura (Tamura, 1984) for isotope scattering and has been proven to adequately describe mass disorder scattering in several alloy materials (Li et al., 2012;Tian et al., 2012), including Si 0.5 Ge 0.5 (Garg et al., 2011). The mass disorder scattering rate is described by with From the g 2 function, it is apparent that a higher mass variance (|ΔM s |/〈M s 〉) leads to increased scattering and therefore results in a reduction of thermal conductivity. The aim of this study was to evaluate the effect of mass disorder resulting from various dopants in the Si 0.5 Ge 0.5 alloy and to compare it to the effect in doped Si. For this purpose, mass disorder from dopants has been introduced into the calculations in the same way as mass disorder from alloys according to Eq. 7.

COMPUTATIONAL DETAILS
DFT calculations have been carried out using the QUANTUM ESPRESSO suite of programs (Giannozzi et al., 2009) within the local density approximation for exchange-correlation interaction (Kohn and Sham, 1965). Norm-conserving, Trouiller-Martins type pseudopotentials (Troullier and Martins, 1991) have been applied to describe the core electrons, while four valence electrons have been treated explicitly for both Si and Ge atoms. An energy cutoff of 50 and 200 Ry, respectively, has been found to be sufficient for the wave function basis set and charge density.
Calculations have been performed using the primitive cell of the face-centered cubic crystal structure containing two atoms. The structure of all systems has been optimized using a 8 × 8 × 8 Monkhorst-Pack k-point (k: electron wave vector) set (Monkhorst and Pack, 1976) resulting in a lattice parameter of a 5.484 Å for Si 0.5 Ge 0.5 .
The virtual crystal approximation (VCA) has been applied for DFT calculations of the SiGe alloy. For this purpose, a virtual crystal pseudopotential has been generated from the pseudopotentials of Si and Ge using the tools provided in QUANTUM ESPRESSO (Hahn et al., 2021).
For the calculation of phonon dispersion, a 4 × 4 × 4 q-grid (q: phonon wave vector) for DFPT calculations has been found to be accurate enough, while a 2 × 2 × 2 q-grid has been used for the calculation of the third-order interatomic force constants.
We remark an important technical issue often overlooked. The finite value applied for σ g in Eq. 6 affects the accuracy of the calculation of the thermal conductivity. Here, σ g has been set to 5 cm −1 offering a reasonable compromise between computational time and accuracy. The accuracy of the calculated thermal conductivity is further affected by the density of the uniform mesh given by the number N 0 of q-points. In particular, in alloys, Frontiers in Mechanical Engineering | www.frontiersin.org July 2021 | Volume 7 | Article 712989 the number of q-points required for reasonable convergence of the thermal conductivity increases with decreasing value of σ g . It was unfeasible to perform all calculations with such high integration grid densities. Therefore, the thermal conductivity for an infinite q-grid has been approximated extrapolating the results for a mesh of N q × N q × N q points with N q 10, 15, 20, and 30 using an exponential function κ κ ∞ exp − a 1 N q . Figure 1 represents this procedure for B-doping with different concentrations. In pure Si, convergence is reached at lower integration grid density. For consistency, the thermal conductivity has also been extrapolated in the pure material.
The linewidth, or inverse relaxation time (Eq. 2), has been calculated on a 40 × 40 × 40 integration grid. It has been obtained for selected doping types and concentrations at 300 K. The thermal conductivity has been calculated in a temperature range from 100 to 1200 K. Most results are presented at 300 K where a thermal conductivity of 12 W/mK and 153 W/mK was obtained in pristine Si 0.5 Ge 0.5 and Si, respectively.

RESULTS
The effect of mass disorder caused by dopants in SiGe has been investigated for the p-type dopants such as B, Al, and Ge as well as for the n-type dopants such as N, P, and As. Since we focus on the influence of mass disorder without considering phonon-carrier interactions or effects from changes in chemical bonds, no further distinction is made between n-and p-type materials.
The concentration of dopants has been changed from 10 19 to 10 22 cm −3 . We duly remark that a concentration of 10 22 cm −3 corresponds to an atomic percentage of 41% of dopant in Si 0.5 Ge 0.5 , thus transforming the material into a ternary system (or binary system in the case of Si) where the dopant would have to be considered as part of the alloy rather than just a perturbation. In fact, the electronic structure and phonon dispersion would have to be recalculated since such high dopant concentrations can lead to a shift from semiconducting to metallic properties (Zhang et al., 2011). Nevertheless, the concentrations 5.10 21 and 10 22 cm −3 have been added to this study to provide a magnification of the trends at lower concentrations rather than to give accurate quantitative behavior.
It has been shown that phonon-electron interactions can notably reduce the thermal conductivity in silicon for carrier concentrations above 10 13 cm −3 (Liao et al., 2015). Phonon-electron interactions are not considered in this study.
The calculated values can therefore be regarded an upper limit for the lattice thermal conductivity. Nq that has been used to obtain the thermal conductivity κ ∞ at an infinite integration grid.  The thermal conductivity as a function of doping concentration is shown in Figure 2. For doping concentrations of N doping ≤ 10 20 cm −3 , corresponding to 0.4 atomic-%, the thermal conductivity is basically unaffected by the introduced mass disorder. Increasing the doping concentration, the greatest effect is observed in the B-doped sample, consistent with the largest mass difference between the dopant and the host material. At a doping level of 10 21 cm −3 , in the B-doped sample, a reduction of 9% is observed with respect to the thermal conductivity in undoped Si 0.5 Ge 0.5 . With increasing mass of the dopant, the effect on the thermal conductivity steadily decreases and is less than 2% for P, Ga, and As. Interestingly, for Ga and As, the opposite trend is observed: thermal conductivity in fact increases with respect to undoped Si 0.5 Ge 0.5 . We attribute this unexpected behavior to a decrease in the mass variance var m , when the dopant is close to the average mass of the alloy, which is 50.354 a. u. for Si 0.5 Ge 0.5 . In fact, the behavior of mass variance (|ΔM s |/〈M s 〉) entering in the scattering rate in Eq. 7 of a ternary system, where the concentration ratio of two components (Si and Ge) remains the same, can be approximated by the following: where m k is the atomic mass of the dopant, and m 1 and m 2 are the mass of Si and Ge, respectively. Based on this equation, the minimal mass variance in Si 0.5 Ge 0.5 is obtained with a third component (dopant) of mass: m min m 2 1 +m 2 2 m 1 +m 2 60.217 a.u. which should lead to a maximum in thermal conductivity.
In fact, we have verified this behavior for a fictitious dopant of mass 60.217 a. u. resulting in an increase of the thermal conductivity by 2.2% at a doping concentration of 10 21 cm −3 (see Figures 3, 4). A slightly smaller increase of κ by 1.8% is found when the doping mass is set to the average mass of the Si 0.5 Ge 0.5 alloy (50.354 a. u.).
This result is very interesting and of great technological importance since it provides evidence that in ternary systems, a maximum thermal conductivity can be engineered by reducing the mass variance. Reduction in the mass variance can possibly be obtained as well from a controlled distribution of isotopes.
For the sake of completeness, in Figure 4, we show the thermal conductivity as a function of dopant mass for several doping concentrations up to 10 22 cm −3 . At high doping concentration, the maximum of κ at m min is clearly visible, and at N doping 10 22 cm −3 , it leads to an increase in the thermal conductivity of 40%.
The scattering spectrum in doped and undoped SiGe has been analyzed calculating the linewidth, that is, the inverse scattering time (Eq. 2), at different wave vectors along high symmetric directions. It is presented in Figure 5 as a function of the phonon dispersion. Upon doping with a fictitious material of mass m min 60.217 a. u., the linewidth of acoustic phonons is in particular reduced in the vicinity of X, whereas a reduction at all wave vectors is observed for optical phonons. Dominant carriers of thermal energy in SiGe-based materials are acoustic phonons,  which, however, are affected by scattering with optical phonons. A reduction of the linewidth of optical phonons therefore results in reduced scattering events between acoustic and optical modes, explaining the enhanced thermal conductivity in SiGe when doped with materials having an atomic mass close to m min . Figure 6 shows the thermal conductivity in undoped SiGe and SiGe doped with B and with a fictitious species of mass m min as a function of temperature. In the temperature range calculated here, the lattice thermal conductivity decreases with increasing temperature as a result of increased Umklapp scattering. B-doping with a concentration of 10 21 cm −3 results in a decrease of κ by 10% at a temperature of 100 K. With increasing temperature, the scattering effect from mass disorder steadily decreased down to 6.7% at 1200 K. Instead, doping with a material of fictitious mass m min 60.217 a. u. leads to an increase of the thermal conductivity by 3.8% at 100 K and 2.4% at 1200 K.

Effect of Mass Disorder in Si
In the case of pure hosts, such as Si, introduction of dopants always results in an increase of mass variance. As a result, the thermal conductivity is highest in the undoped material and decreases with increasing difference between dopant and host mass (Figure 7).
Different to Si 0.5 Ge 0.5 , the thermal conductivity is notably reduced already at a doping concentration of 10 19 cm −3 when the introduced dopants lead to a high mass variance (Ga and As). This effect is most pronounced for As, resulting in a reduction of 16%. At N doping 10 21 cm −3 , a remarkable decrease of the thermal conductivity is observed for all second and fourth period elements, showing a decrease in κ of 56, 49, and 80% for B, N, and As, respectively. The masses of Si and Al are very similar, resulting in indeed small effects of Al doping on the thermal conductivity of Si. Even at the highest concentration of 10 22 cm −3 , a reduction of only 7% is observed. Figure 8 shows the thermal conductivity as a function of doping concentration. For a high mass variance, as it is the case for Ga and As, the thermal conductivity drops fast by roughly 90% at a doping concentration of 5.10 21 cm −3 . Further increase to 10 22 cm −3 , however, does not alter the thermal conductivity any further. For doping with elements of the second period, B and N, the thermal conductivity continues to decrease from 33 to 23 W/ mK and from 41 to 30 W/mK, respectively. The relative mass variance in doped Si 0.5 Ge 0.5 (compared to undoped Si 0.5 Ge 0.5 ) is in general lower with respect to doped Si. Therefore, the behavior of κ as a function of dopant concentration in Si 0.5 Ge 0.5 (Figure 2) can only be compared to the behavior in doped Si with low mass variance. In fact, a similar trend is found for Al-and P-doping of Si and all doping types in Si 0.5 Ge 0.5 . FIGURE 6 | Thermal conductivity in undoped Si 0.5 Ge 0.5 (red diamonds) and doped with B (blue triangles) and a fictitious species with mass m min (green circles) at a concentration of 10 21 cm −3 as a function of temperature.  Experimental studies have reported a lower thermal conductivity in B-doped Si than in P-doped samples (Slack, 1964;McConnell et al., 2001), which is in good agreement with our results. Scattering events resulting from electron-phonon and hole-phonon interactions could additionally reduce the thermal conductivity in Si as it had been shown previously by first-principles calculations (Liao et al., 2015). In fact, hole-phonon scattering has been shown to be stronger than electron-phonon scattering, resulting in a lower thermal conductivity of p-type Si (Liao et al., 2015). This effect adds to the mass-variance one above discussed, thus justifying the comparatively lower thermal conductivity experimentally found in B-doped Si (p-type).
Scattering rates in undoped Si (Figure 9) are remarkably smaller with respect to the ones in SiGe. Introduction of mass disorder by dopants already at medium concentrations (here shown for 10 20 cm −3 ) drastically increases the linewidth of optical phonons, for B-doping. Note that for better visualization, the linewidth in Figure 9 has been multiplied by a factor of 20. The highest increase of the linewidth of acoustic phonons is observed at K for longitudinal modes. Even though low-frequency acoustic phonons are known to be the main carriers for thermal transport, increase of the phonon linewidth of optical modes increases scattering, with the former explaining the notable reduction of thermal conductivity in doped Si.
In agreement with the literature, the thermal conductivity of Si decreases with increasing temperature (Figure 10) as a result of increased Umklapp scattering processes. Similar to SiGe, the effect of mass disorder is higher at low temperatures and decreases steadily with increasing temperatures. At a doping concentration of 10 20 cm −3 with As, the thermal conductivity is reduced with respect to pristine Si by 81 and 27% at 100 and 1200 K, respectively. This demonstrates that scattering from mass disorder is more pronounced at low temperatures, while other scattering effects (e.g., Umklapp scattering) become more important at higher temperature.
The general trend of decreasing thermal conductivity with increasing carrier concentration in both Si 0.5 Ge 0.5 and Si is in agreement with experimental data (Dismukes et al., 1964;Slack, 1964;McConnell et al., 2001). Since most theoretical studies so far have focused on the contribution of phonon-electron interaction in doped materials (Liao et al., 2015;Xu et al., 2019), the role of mass disorder and variance is still unclear. With this study, we have shown that mass disorder does play a role at high doping concentrations and suggest that both mechanisms should be investigated simultaneously in a future study.

CONCLUSION
The effect of mass disorder due to dopants on the thermal conductivity in Si 0.5 Ge 0.5 has been investigated by firstprinciples calculations. III-group elements such as B, Al, and Ga have been considered for p-type doping and V-group elements such as N, P, and As for n-type doping with concentrations ranging from 10 19 to 10 22 cm −3 .
Scattering from mass disorder is already present in the undoped Si 0.5 Ge 0.5 alloy. Notable effects on the thermal conductivity from doping-induced mass disorder are therefore observed only at concentrations of 5.10 20 cm −3 and higher. Doping with B generates the highest mass variance in the FIGURE 9 | Phonon dispersion of Si undoped (left) and doped with B (right). The linewidth (inverse relaxation time) of acoustic and optical modes is represented in yellow and cyan, respectively. For better visual presentation, the value of the linewidth has been multiplied by 20.
FIGURE 10 | Thermal conductivity in undoped Si (red diamonds) and doped with N (blue triangles), p (green circles), and As (pink triangles) at a concentration of 10 20 cm −3 as a function of temperature.
Frontiers in Mechanical Engineering | www.frontiersin.org July 2021 | Volume 7 | Article 712989 Si 0.5 Ge 0.5 system, resulting in the most pronounced reduction of the thermal conductivity, namely, 9% at a concentration of 10 21 cm −3 . Slightly lower reduction is found for N-doping. At this concentration, for dopants P, Ga, and As, the effect on the thermal conductivity is less than 2%. Interestingly, for Ga and As, an increase in the thermal conductivity is observed. This results from a reduced mass variance with respect to the undoped Si 0.5 Ge 0.5 . In fact, the minimal mass variance in doped Si 0.5 Ge 0.5 is given for a dopant with m min 60.217 a.u. The thermal conductivity has been calculated for a fictitious dopant of this mass, resulting in an increase of the thermal conductivity by 2.2% at 10 21 cm −3 . This result is of great technological importance since it proofs the possibility to maximize the thermal conductivity in alloys by introducing a third component with suitable atomic mass.
In contrast to Si 0.5 Ge 0.5 , doping in Si always leads to a reduction of the thermal conductivity. Notable decrease is already observed at a concentration of 10 19 cm −3 and is most pronounced for As in agreement with the highest mass variance.

DATA AVAILABILITY STATEMENT
The raw data supporting the conclusion of this article will be made available by the authors, without undue reservation.

AUTHOR CONTRIBUTIONS
KH carried out the calculations and analysis of the data, and prepared the first draft of the manuscript. All authors equally contributed to the design of the study, manuscript revision, reading, and approved the submitted version.