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Biocellulose scaffold obtained by in situ modifications with water-soluble cellulose derivative

Hernane Barud1, 2, Marina L. Fontes1, Agnieszka Tercjak3, Juncal Gutierrez3, Andréia Meneguin2, Aline M. Santos2 and Sidney J. Ribeiro2
  • 1 UNIARA, Biotecnology, Brazil
  • 2 IQ/UNESP, Inorganic Chemistry, Brazil
  • 3 UPV, Group ‘Materials + Technologies’ (GMT), Department of Chemical and Environmental Engineering,, Spain

Tissue engineering is to develop alternative methods for tissue regeneration, applicable to degenerative processes, and congenital deformities in progressive disease, among other possibilities.

In this scenario, the bacterial cellulose stands out as a promising biopolymer for the preparation of scaffolds and their use in tissue engineering as temporary substituents of injured or damaged tissue.In this work we have prepared and characterized scaffolds based on biocelluloseby in situ modification  by using a water-soluble cellulose derivative, which is, carboxymethylcellulose (CMC). Modified BC scaffolds wew characterized by different physico-chemical tests, namely, Atomic ForceMicroscopy (AFM) and Fourier Transform Infrared Spectroscopy (FTIR).The results revealed additional features bacterial cellulose, such as increased adhesion and deformation and demonstrated the incorporation of the CMC structure effectively cellulose.

Fapesp; Capes; CNPq

References:
[1] CHAVES-PACHECO, J. L.; MARTINEZ-YEE, S.; CONTRERAS-ZENTENA, M.; ESCAMILLÁ- MARVÁN, E. Cellulosa Bacteriana en Gluconacetobacter xylinum: biossíntese y aplicaciones. Revista Especializada em Ciências Quimico-Biológicas, v. 7. p. 18-25, 2004. DONINI Í. A. N. et al. Biossíntese e recentes avanços na produção de celulose bacteriana. Eclet.Quím. vol.35 nº.4 São Paulo 2010. KE, H.; ZHOU, J. & ZHANG, L. Structure and Physical Properties of Methylcellulose synthesized in NaOH/ urea solution. PolymerBulletin, v. 56, p. 349-357, 2006.

Keywords: Biocompatibility, 3D scaffold, biofunctionalization

Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.

Presentation Type: Poster

Topic: Synthetic scaffolds as extracellular matrices

Citation: Barud H, Fontes ML, Tercjak A, Gutierrez J, Meneguin A, Santos AM and Ribeiro SJ (2016). Biocellulose scaffold obtained by in situ modifications with water-soluble cellulose derivative. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.00021

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Received: 27 Mar 2016; Published Online: 30 Mar 2016.