Total Synthesis of Himastatin

04 October 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The synthesis and study of antibiotic natural products with unique structures and mechanisms of action represents a proven strategy to combat the public health crisis posed by antibiotic-resistant bacteria. The natural product himastatin is an antibiotic with an unusual homodimeric structure that presents a significant synthetic challenge. We report the concise total synthesis of himastatin by a newly developed final-stage dimerization strategy that was inspired by a detailed consideration of its biogenesis. Combining our bio-inspired dimerization approach with a modular synthesis enabled expedient access to a number of designed derivatives of himastatin, including synthetic probes that provide insight into its antibiotic activity.

Keywords

Total Synthesis
Antibiotic
Himastatin
Dimerization
Oxidation

Supplementary materials

Title
Description
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Title
Total Synthesis of Himastatin-SI
Description
Supporting Information File
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