Management of ameloblastoma and its consequences

ameloblastoma. 8 The study also shows recurrences have been accounted from 1 to 45 years after enucleation. 8 In asymptomatic patient, observation of CT scan at expanding at intervals of 5 years ameloblastoma, if untreated, can develop a substan-tial size and represent metabolic abnormali-ties. 8 Moreover, reports have archived metastatic ameloblastoma to the lungs related with a para-neoplastic disorder causing hypercalce-mia. Deaths in patients with multiple surgical exploration have been encountered. 8 Patients with uncontrolled ameloblastoma may extend into the focal sensory system. Recent reports for metastatic ameloblastoma demonstrate a dis-ease free survival time 13 years. 9 Abstract The study considered clinical prospective observation of 113 patients suffered from different variety of ameloblastoma. Among them, 75% female were more often affected. Half (27.1%) of the patient was treated by dredging, 58.8% dredging with carnoy’s solution, and 33.9% by disarticulation with hemimandibulectomy using reconstruction plate. For the first five years, participants were recalled at every 3, 6 and 12 months, and then after every 2 years. 70% patients were drop out within 2 years and the rest of the patients had varying recurrence rate. The late recurrence recorded only one patient at 17 years of treatment by dredging 3 patients had unusual seedling (distance metastasis) in the lungs one patient in the leg and one patient with scalp. All this distance metastasis patents were treated by different modalities. The distance metastasis cannot rule out in any definite criteria. The study concluded that in case of carnoy’s solution, the recurrence rate is slow and safe measure to manage the patient without mutilating surgery.

The most cases are diagnosed at the age of 30-60 years old .2 Recent WHO grouping solid/ multicystic, unicystic, desmoplastic and peripheral, limitation, and size of the tumors depends on age of the patient. 3 There are two fundamental histopathologic designs; the follicular and plexiform without clinical significance. 3 The plexiform variety containing cystic stroma. 3 The follicular variety shows numerous islands of tumor cells in stringy stromal tissue. It was indicated the two variety represent 64.1% of 693 ameloblastomas. 3 The expression of cell-multiplying markers, multiplying cell atomic antigen (PCNA), Ki-67 antigen and topoisomerase II, has been researched by immunohistochemistry implies to anticipate the organic conduct of neoplastic cells in different variety of ameloblastoma. 3,4 Many study shows PCNA and Ki-67 hostile to gene were higher in the follicular variety with plexishape variety. 5,6 Induction deduced IHC with the counter to poisomerase II immunizer to recognize multiplying cells in ameloblastoma. 7 Kumamoto proposed that, incomprehensibly in ameloblastoma, the expression of p53 protein mirrored the multiplication action of neoplastic cells, as opposed to apoptosis. 7 The study suggested that odontogenic epithelium, p21 protein articulation related with cell separation and apoptosis. Quantity of p21 protein predicting the organic conduct of ameloblastoma. 8 The study also shows recurrences have been accounted from 1 to 45 years after enucleation. 8 In asymptomatic patient, observation of CT scan at expanding at intervals of 5 years ameloblastoma, if untreated, can develop a substantial size and represent metabolic abnormalities. 8 Moreover, reports have archived metastatic ameloblastoma to the lungs related with a para-neoplastic disorder causing hypercalcemia. Deaths in patients with multiple surgical exploration have been encountered. 8 Patients with uncontrolled ameloblastoma may extend into the focal sensory system. Recent reports for metastatic ameloblastoma demonstrate a disease free survival time 13 years. 9

Materials and Methods
The empirical study was carried out at the present place as well as at Dhaka Dental College, Mirpur, Dhaka, Bangladesh over 17 years of follow-up conducted on 113 patients who were diagnosed as different variety of ameloblastoma. The patients were categorized | Original | Article |

Abstract
The study considered clinical prospective observation of 113 patients suffered from different variety of ameloblastoma. Among them, 75% female were more often affected. Half (27.1%) of the patient was treated by dredging, 58.8% dredging with carnoy's solution, and 33.9% by disarticulation with hemimandibulectomy using reconstruction plate. For the first five years, participants were recalled at every 3, 6 and 12 months, and then after every 2 years. 70% patients were drop out within 2 years and the rest of the patients had varying recurrence rate. The late recurrence recorded only one patient at 17 years of treatment by dredging 3 patients had unusual seedling (distance metastasis) in the lungs one patient in the leg and one patient with scalp. All this distance metastasis patents were treated by different modalities. The distance metastasis cannot rule out in any definite criteria. The study concluded that in case of carnoy's solution, the recurrence rate is slow and safe measure to manage the patient without mutilating surgery.

Article Info
Depa Three patient included in this study had a history of multiple consecutive surgery by enucleation and curettage.

Results
Out of 113 patient addressed, conservative treatment by enucleation and dredging included 68 multicystic ameloblastoma and 45 unicystic ameloblastoma. In case of failure of treatment, 27.1% of patients were treated by disarticulation followed by reconstruction plate. From this 5 patients addressed, soft tissue recurrence occurred within two years of follow-up.
Case 1: The surgical procedure of the patient with unilateral unicystic ameloblastoma was performed at the age of 17 years. The recurrence occurred following six month after initial procedure. Repeated same surgical procedure followed up to 5 years and aggressiveness increases with evidence of cortical bone losses with soft tissue involvement five cycle radio therapy is being implemented. After -wards the ameloblastic tissue grows vigorously with increase of aggressiveness with the CT-scan findings heterogeneously enhancing mixed density mass is noted in the right ethmoid sinus and right parapharyngeal space with the destruction of adjacent bone. Cystic degeneration was noted within the lesion. Another large lobulated mass with central necrosis was noted in the right side of the scalp with scalloping of underlying skull bones. Both eyeballs and visualized portion of brain were unremarkable. After vigorous resection of the tumor mass the patient was even full and no recurrence occurred in 5 years follow-up, complete procedure was carried out for 23 years.
Case 2: The patient with bilateral unicystic ameloblastoma at the age of 9 years same surgical procedure was performed up to 12 years. The ameloblastic tissue grows such a drastic manner that the whole of oral cavity was covered by the ameloblastic tissue and patient suffered from suffocation artificial ventilation is needed for his survival, afterwards due to repeated surgical procedure patient died with developed of hypokalemia.
Case 3: Three patients with multicystic ameloblastoma after enucleation and curettage no evidence of local recurrence is noted in first surgical procedure but metastatis in the lungs noted 2 years after surgical procedure (desmoplastic variety) second patient metastatis in the lungs after 5 years of primary treatment and third metastatis in the leg after 17 years of primary treatment.
Thirty patients treated by enucleation with cornoy's solution 4 patients noted recurrence after 5 years of primary treatment. Rests of the patients recovered. Three patients treated by disarticulation with bone grafting among them one patient having recurrence in the grafted bone after 7 years of surgery.
Seventeen patients were treated by enucleation and dragging repeated procedure was performed from 5 -10 years (Table I).

Discussion
In this study, there were 40% local recurrence and 2.8% distant metastatis in case of enucleation and curratage. In the use of cornoy's solution, 1.2% recurrence was documented. In case of disarticulation followed by bone grafting 0.3% recurrence occurs in grafted bone. Disartculation followed by shows 100% positive result compatible with the different study. Recent experimental opinion regarding management of ameloblastoma has greatly changed. The entire recent researcher shows the special emphasis over histopathologial evaluation gene analysis tissue typing and safety resection margin 1.5-2 cm aside from the radiological limit. 10 A current systematic overview demonstrated that the enucleation of unicystic ameloblastoma resulted in the greatest recurrence rate; and also the lowest recurrence rate was linked with resection with the tumor. 11 Enucleation on its own yielded 30.5% recurrence rate, associated with a recurrence rate of 18% regarding dradging, 12 16% regarding enucleation with application Carnoy's solution and 3.6% for resection. Three histologic varieties of unicystic ameloblastoma are mentioned within the literature. 13 Within the first kind, luminal ameloblastoma, the actual tumor is limited to the luminal surface of the cyst. 11, 13 In the second kind, which is intraluminal ameloblastoma, tumor nodules project from the cystic lining into the lumen of the cyst. In the third type, mural ameloblastoma, the fibrous wall structure of the cyst is penetrated with tumor nodules. The third kind is regarded as probably the most hostile, with a recurrence rate as high as 35.7%. Various possibilities happen to be documented between different locations of the unicystic ameloblastoma relating to its spreading potential. It has been seen that the tumor nodes in the cyst wall have higher proliferating cell nuclear antigen. This particular breakthrough offered a biologic groundwork to advocate a much more revolutionary surgical removal as the therapy of choice for unicystic ameloblastoma. It was recommended that unnecessary resection of the mandible constituted an extreme procedure. 11 As recurrence reported from one to 45 years after inoculation. 14, 15

Conclusion
The study concluded irrespective of recurrence, the management of ameloblastoma has been greatly changed. Bizarre characteristic of the ameloblastic tissue requires further evidence based research with special emphasize on the evaluation of p53, p21 protein with analysis of CD10, KI67 antigen leveling index clinical, immuno-histopathological correlation with long-term follow-up.