Trace Minerals and Oxidative Stress in Diabetic Retinopathy

Authors

  • Suchitra Kumari Asst. Professor, Dept. of Biochemistry, AIIMS, Bhubaneswar
  • Tapaswini Pradhan Assoc. Professor, Dept. of Biochemistry, KIIMS, BBSR.
  • Tarun Kumar Panda Asst Surgeon, Dept. of Ophthalmology, SCB Medical College, Odisha

DOI:

https://doi.org/10.3329/bjms.v13i2.14963

Keywords:

trace elements, peroxidative status, diabetic retinopathy

Abstract

There is accumulating evidence showing relationship between trace elements and Diabetes mellitus (DM). This study evaluated the role of magnesium, Zinc and other indices of peroxidative status ie MDA, Vitamin C and Vitamin E in pathogenesis of Retinopathy in type 2 diabetes. Seventy two type 2 diabetes cases were enrolled in the study, of which 42 were with retinopathy and 30 without. Patients with nephropathy were excluded. Forty age and sex matched subjects were served as health controls. The results showed that the mean values of Mg and Zn were significantly lower reduced in diabetes more so in diabetic retinopathy cases as compared to control subjects (p<0.05). Lipid peroxidation marker MDA was a significantly higher in both the diabetes groups whereas serum Vitamin C and vitamin E levels were significantly low (p<0.05) as compared to controls. Our correlation study revealed that MDA was negatively associated with serum Mg (r=-0.73, p<0.01) as well as serum Zn (r= -0.82, p<0.01), pointing towards the role of these trace elements in retarding the oxidative process prevailing in diabetic retinopathy.

DOI: http://dx.doi.org/10.3329/bjms.v13i2.14963

Bangladesh Journal of Medical Science Vol.13(2) 2014 p.175-179

Downloads

Download data is not yet available.
Abstract
1226
PDF
788

Downloads

Published

2014-03-03

How to Cite

Kumari, S., Pradhan, T., & Panda, T. K. (2014). Trace Minerals and Oxidative Stress in Diabetic Retinopathy. Bangladesh Journal of Medical Science, 13(2), 175–179. https://doi.org/10.3329/bjms.v13i2.14963

Issue

Vol. 13 No. 2 (2014)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.