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Study found that, contrary to findings of recent studies, neuroleptic drug treatment of aggressive behaviour in adults with intellectual disability conferred no significant benefits and that placebo treatment was a more cost-effective option

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P Tyrer, P Oliver-Africano, R Romeo, M Knapp, S Dickens, N Bouras, Z Ahmed, S Cooray, S Deb, D Murphy, M Hare, M Meade, B Reece, K Kramo, S Bhaumik, D Harley, A Regan, D Thomas, B Rao, S Karatela, L Lenôtre, J Watson, A Soni, M Crawford, J Eliahoo & B North.

P Tyrer 1,*, P Oliver-Africano 1, R Romeo 2, M Knapp 2, S Dickens 1, N Bouras 3, Z Ahmed 4, S Cooray 5, S Deb 6, D Murphy 7, M Hare 4, M Meade 1, B Reece 1, K Kramo 1, S Bhaumik 8, D Harley 9, A Regan 10, D Thomas 11, B Rao 1, S Karatela 9, L Lenôtre 5, J Watson 8, A Soni 12, M Crawford 1, J Eliahoo 13, B North 13

1 Department of Psychological Medicine, Imperial College, London, UK
2 Centre for Economics of Mental Health, Box P024, Institute of Psychiatry, De Crespigny Park, London, UK
3 Mental Health in Learning Disabilities Centre, King’s College London, Institute of Psychiatry, Estia Centre, Guy’s Hospital, London, UK
4 Welsh Centre for Learning Disabilities Clinical Studies, University of Wales College of Medicine, Cardiff, UK
5 Central North West London Foundation NHS Trust, Kingsbury Community Unit, Brent, London, UK
6 Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham, UK
7 Section of Brain Maturation, Institute of Psychiatry, London, UK
8 Leicestershire Partnership NHS Trust, Leicester Frith Hospital, Leicester, UK
9 Queensland Centre for Intellectual and Developmental Disability (QCIDD), School of Population Health, University of Queensland, Brisbane, Australia
10 Harrow Primary Care NHS Trust, Orme Lodge, Stanmore, Middlesex, UK
11 North East London Mental Health NHS Trust, Redbridge Learning Disability Service, Barkingside, Essex, UK
12 West London Mental Health NHS Trust, Hammersmith & Fulham Mental Health Unit, London, UK
13 Statistical Advisory Service, Imperial College, London, UK
* Corresponding author Email: p.tyrer@imperial.ac.uk

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