Open Access

REVIEW

Mesenchymal stem cell-derived exosome as a nano weapon to target the COVID-19 pandemic

YASHVI SHARMA, SUCHI GUPTA, SUJATA MOHANTY^*

Stem Cell Facility (DBT-Centre of Excellence for Stem Cell Research), All India Institute of Medical Sciences, New Delhi, 110029, India

* Address correspondence to: Sujata Mohanty,

(This article belongs to this Special Issue: Stem Cells, Protein Therapeutics, and Regenerative Medicine)

BIOCELL 2021, 45(3), 517-520. https://doi.org/10.32604/biocell.2021.014621

Received 13 October 2020; Accepted 21 December 2020; Issue published 03 March 2021

Abstract

In these times of despair when a nano-sized organism, the SARS-CoV-2, has rendered the human race helpless, made the global health status decline, and drowned the world economy, a ray of hope comes from another nano-sized particle, the exosome. The potential of mesenchymal stem cells has already been established in COVID-19; however, cell-based therapy has its risks. We thereby propose cell-free therapy using stem cells-derived exosomes to fight against COVID-19, as they can be a game-changer owing to their immunomodulatory nature, which combats the cytokine storm characterizing this disease, and their practical efficiency, which will realistically aid large access to therapy worldwide.

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Keywords

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