Polycystic ovary syndrome (PCOS)

What is Polycystic Ovary Syndrome? PCOS is an endocrine disorder that is characterized by insulin resistance, hyperandrogenism, obesity, and ultimately infertility. Today, PCOS is considered one of the most common endocrine disorders. It generally affects 1 out of 10 women in their fertile age. The diagnosis of PCOS patients is very complex, since it is a multiform syndrome. That is reason because a diagnostic of exclusion has been established. This means that for women to be treated as a PCOS patient, they must show hyperandrogenism and ovulatory dysfunction. [1] When excessive amounts of androgens are secreted into the body, it is usually evident by the presence of acne, hirsutism (excessive production of hair), or frontal alopecia (lack of hair in the frontal area.) Hyperandrogenism is caused by the impairment in gonadotropin releasing hormone (GnRH) secretion that supports luteal hormone (LH) secretion. Insulin sensitivity is decreased in PCOS patients. This creates insulin resistance and growth of compensatory hyperinsulinemia. PCOS patients also tend to have higher levels of adipose tissue in the abdominal area due to the excessive production of androgens and the insulin sensitivity. This adipose tissue focuses on the abdominal area. It increases the risk of carbohydrates intolerance, and it develops abdominal obesity which can cause miscarriages and infertility. PCOS patients with higher body mass index (BMI) are more predisposed to have menstrual PCOS, but most of these treatments only focus on the symptoms and not in the root of the syndrome. Such is the case of Metformin, which has been able to fight many of the symptoms but has not been able to eradicate the syndrome. PCOS is a syndrome that affects not only the women that have this disorder, but her family as well.


Polycystic Ovary Syndrome (PCOS)
What is PCOS?
Polycystic ovary syndrome (PCOS) is a common hormone disorder that affects 5-10% of women.Like all syndromes, PCOS is a collection of problems that are found together.Not all women with PCOS have all the same symptoms.To be diagnosed with PCOS, a woman must have 2 of 3 possible issues: chronic lack of ovulation (anovulation, where the patient does not develop and release an egg from the ovary on a regular basis), chronic high testosterone hormone levels (hyperandrogenism, which can lead to acne or excess facial and midline hair growth), and ovaries that have multiple small fluid-filled sacs (antral follicles).The follicles are different from large ovarian cysts.

How is PCOS diagnosed?
Because this condition is diagnosed by identifying several different problems, PCOS is diagnosed using a combination of physical exam findings, history, ultrasound (sonogram) results, and blood tests.
Women who have PCOS may complain of irregular or missed menstrual periods or a long time between periods (typically < 6 cycles per year).They may also be overweight, have increased hair growth (hirsutism), acne, or be unable to get pregnant.
On ultrasound, women with PCOS may have enlarged ovaries with many small follicle.Blood tests may show high blood sugar, high cholesterol levels, or high levels of male hormones.
What risks do women with PCOS have?
Some of the risks of PCOS are related to a woman not ovulating regularly.When ovulation doesn't happen, it interrupts the usual hormone cycle and causes the lining of the uterus to be exposed to constant levels of estrogen without progesterone, since progesterone levels increase with ovulation.This can encourage the lining to become too thick and cause abnormal bleeding.It also may lead to uterine cancer or pre-cancerous changes.This lack of regular ovulation can also make it difficult to get pregnant (infertility).
Metabolic syndrome is also common in women with PCOS.Symptoms include extra weight around the abdomen, high cholesterol, high blood pressure, and insulin resistance/diabetes.Each of these symptoms raises the risk of heart disease.In the U.S., obesity is common in women with PCOS.

How is infertility in women with PCOS treated?
Infertility in women with PCOS is due to failure to ovulate (produce and release an egg).Ovulation can be induced using oral medicine.Clomiphene citrate is a medication taken by mouth to stimulate ovulation.Letrozole is another oral medicine that is used and can be particularly helpful for women with PCOS.If oral medications are unsuccessful, injected fertility medicines called gonadotropins may be given to stimulate the growth of an egg.Women with PCOS must be watched very carefully when these medicines are used to make sure that they are responding appropriately.
If a woman is overweight, losing weight can also help improve ovulation patterns and fertility.
Insulin-sensitizing medicines such as metformin can help the body use insulin more effectively to improve ovulation.
This may also lower the risk of developing diabetes or metabolic syndrome.
In vitro fertilization (IVF) may help women with PCOS get pregnant if other treatments do not work.
How is PCOS treated in women not trying to get pregnant?
If fertility is not the goal, taking hormone medication usually helps to correct PCOS symptoms.Oral contraceptive pills (birth control pills) are often taken to reduce extra hair growth and acne.The pill can also make menstrual periods more regular, prevent pregnancy, and reduce the risk of uterine cancer.Metformin can also be given to help lower the risk of developing diabetes or metabolic syndrome.
Excess hair and acne can be treated with medicines that work locally at the skin, like spironolactone.Excess hair can also be removed using electrolysis and laser treatment.Losing weight lowers the risk of diabetes and androgen levels in many women with PCOS.
Treatment should be tailored to each woman's needs, symptoms, and particular situation, and may change over time.Talk with your health care provider to find out the best approach for you.