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The idea of “precision public health” (PPH) was proposed as an alternative to a one-size-fits-all approach to improving population health, which is not always effective. PPH aims to develop and apply interventions in a customized way, taking into account the detailed information about the target group. To enable the implementation of PPH in practice, we are developing an ontology-driven software platform that provides: a) access to detailed up-to-date information about population health, b) a structured machine-readable repository of evidence about public health interventions, and c) a set of intelligent tools to facilitate the assessment of evidence transferability, i.e. to determine how well certain interventions fit a given population.