Real-Time Surveillance for Respiratory Disease Outbreaks, Ontario, Canada

To validate the utility of a chief complaint–based emergency department surveillance system, we compared it with respiratory diagnostic data and calls to Telehealth Ontario about respiratory disease. This local syndromic surveillance system accurately monitored status of respiratory diseases in the community and contributed to early detection of respiratory disease outbreaks.

To validate the utility of a chief complaint-based emergency department surveillance system, we compared it with respiratory diagnostic data and calls to Telehealth Ontario about respiratory disease. This local syndromic surveillance system accurately monitored status of respiratory diseases in the community and contributed to early detection of respiratory disease outbreaks.
T he threat of emerging infectious diseases, such as severe acute respiratory syndrome and pandemic infl uenza, makes early detection of health events critical for effective control and intervention of such outbreaks. By using alternative, electronic data sources (1), real-time syndromic surveillance systems have the potential to detect outbreaks of respiratory disease before conventional diagnosis-and laboratory-based surveillance identifi es them. Many of these alternative data, such as sales of over-the-counter drugs, telephone health hotlines, and emergency department (ED) triage data, already are routinely collected.
ED syndromic surveillance typically uses a patient's chief complaint (CC) as recorded by a triage nurse. Respiratory CC data correlate strongly with discharge data (2). CC data from EDs have been successfully integrated into several surveillance systems (3,4), including the ED system in Kingston, Ontario, Canada (5,6). CC data are effective for early identifi cation of infl uenza outbreaks (7,8).
In September 2004, the Queen's University Emergency Syndromic Surveillance Teama created a real-time emergency department surveillance system (EDSS) to monitor respiratory and gastrointestinal CCs temporally and spatially. Seven hospitals from the southeastern Ontario region fed electronic CC data into the system. Routine patient data collected without identifi ers include date and time of visit, demographic information, 5-digit postal code of residence, Canadian Triage Acuity Score, and CC or reason for visit. The National Ambulatory Care Reporting System (NACRS) gathers data for hospital-and community-based ambulatory care, day surgery, outpatient clinics, and EDs. Records contain patient diagnosis according to International Classifi cation of Diseases, 10th Revision-Canadian Enhancement (ICD-10-CA) codes. Every hospital in Ontario submits data to NACRS, and the system includes demographic, clinical, and administrative data for the entire province (9). Telehealth Ontario is the teletriage helpline available free to all Ontario residents 24 hours a day, 7 days a week. Callers are connected to skilled nurses who assess symptoms over the phone and assist callers in making the most appropriate healthcare decision (10). Each caller's demographics are recorded, and each call is assigned a guideline after the nurse has gone through a list of questions about why the person has called.

The Study
We conducted an investigation to verify and validate the utility of a triage CC-based EDSS in southeastern Ontario as a tool for monitoring respiratory disease by comparing it retrospectively with data from NACRS and Telehealth Ontario. This study was part of a broader research project approved by the Queen's Research Ethics Board and adheres to the principles and policies for the protection of personal health information charter.
We retrospectively studied data for July 4, 2004-March 31, 2006. Daily counts of discharges of persons with respiratory disease based on ICD-10-CA codes were obtained from the NACRS database, and counts of respiratory CCs were likewise collected from EDSS. Patient location was determined by forward sortation address (i.e., fi rst 3 digits of postal code) and health unit code in the NACRS database and by specifi c reporting hospital in the EDSS data set. Weekly Telehealth Ontario counts of respiratory disease based on guidelines were also obtained. We categorized Telehealth Ontario calls into episodes of upper or lower respiratory disease on the basis of a priori classifi cation schemes verifi ed by other research (6,(11)(12)(13). Telehealth Ontario calls were geolocated by forward sortation address. All data were compiled into weekly totals (Sunday-Saturday) from each of the 3 nonidentifi able data sets. During

Conclusions
This study verifi ed that ED CC data can be used as a timely source of surveillance for respiratory diseases. ED CCs in southeastern Ontario strongly correlated in time with NACRS respiratory discharge diagnoses and calls to Telehealth Ontario about respiratory disease. NACRS data are unavailable to public health stakeholders in a timely enough fashion to be useful for day-to-day monitoring of respiratory disease trends in the community, whereas ED CCs are available electronically and in real time.
As expected, EDSS CCs about respiratory disease peaked during the infl uenza seasons (early November 2004-mid-April 2005 and early December 2005-early May 2006) (Figure); however, EDSS CCs continued to fl uctuate during the infl uenza off season, probably because of other respiratory pathogens. The nature of the EDSS data did not allow us to separate respiratory complaints related to infl uenza from those related to other pathogens. Further analysis is needed to correlate CC subsets with laboratory-positive infl uenza cases.
One consideration for interpreting EDSS data is that the hospitals in this surveillance system include large referral hospitals that have high volumes of patients visiting from outside our health unit boundaries. Although this large referral area may result in higher counts of visits than refl ected in the NACRS database, we believe it does not affect our interpretation of the data. Even though each hospital is required to submit data, it is still possible that not all records from each hospital are sent on time to NACRS.
Although the public health system has accepted syndromic surveillance as a useful tool, doubts remain about its anticipated early warning benefi ts (14). These potential benefi ts cannot be tested because no large-scale outbreaks have occurred since the inception of our real-time syndromic surveillance system. Protocols of many pandemic-preparedness plans include monitoring of real-time systems. When a pandemic occurs, syndromic surveillance may be able to help healthcare workers recognize a potential outbreak, which theoretically could help them mitigate effects on society earlier. Our study demonstrates that in southeastern Ontario, ED CCs accurately refl ect respiratory conditions of patients in the area. The correlations found strongly suggest that EDSS accurately monitors respiratory disease in the community and contributes to early detection of respiratory disease outbreaks. We continue to monitor the system from day to day and have increased the number of reporting hospitals to 9. Future studies will use laboratory data to assess the value of advanced warning on a number of syndromes captured in our system.

Acknowledgments
We thank the Queen's Public Health Informatics team for editorial assistance. Data were provided by the Ontario Ministry of Health and Long-Term Care and Clinidata, a division of Sykes Assistance Services Corporation.