einstein (São Paulo). 06/Jun/2023;21:eAO0251.
Serum amyloid A in children and adolescents: association with overweight and carotid intima-media thickness
Maria Vitória Mareschi Barbosa
, João Carlos Pina Faria
, Stephanie Ramos Coelho
, Fernando Luiz Affonso Fonseca
, Andrea Paula Kafejian Haddad
, Fabíola Isabel Suano de Souza
, Roseli Oselka Saccardo Sarni
DOI: 10.31744/einstein_journal/2023AO0251
Highlights
■ Serum amyloid A is an acute phase inflammatory protein.
■ Excess weight causes meta-inflammation with a consequent increase in the synthesis of C-reactive protein and serum amyloid A.
■ Carotid intima-media thickness measurement evaluates atherosclerosis before atheromatous plaque formation.
ABSTRACT
Objective
To compare serum amyloid A concentrations between overweight and eutrophic children and adolescents and to relate it to lipid profiles, glucose tolerance, and carotid intima-media thickness.
Methods
One hundred children and adolescents (mean age: 10.8±3.16 years) were included and divided into two groups: overweight and non-overweight. The following were evaluated: Z-score body mass index, carotid intima-media thickness, lipid metabolism biomarkers (lipid profile and apolipoproteins A1 and B), inflammatory biomarkers (ultra-sensitive C-reactive protein and serum amyloid A), and glucose homeostasis model assessment of insulin resistance.
Results
The groups were homogeneous in age, sex, and pubertal stage. Higher levels of triglycerides, apolipoprotein B, homeostasis model assessment of insulin resistance, ultrasensitive C-reactive protein, serum amyloid A, and carotid intima-media thickness were observed in the overweight group. In the multivariate analysis, age (OR=1.73; 95%CI: 1.16-2.60, p=0.007), Z-score body mass index (OR=3.76; 95%CI: 1.64-8.59, p=0.002), apolipoprotein-B (OR=1.1; 95%CI: 1.01-1.2, p=0.030), and carotid intima-media thickness (OR=5.00; 95%CI: 1.38-18.04, p=0.014) were independently associated with serum amyloid A levels above the fourth quartile of the studied sample (>9.4mg/dL).
Conclusion
Overweight children and adolescents had higher serum amyloid A concentrations than eutrophic children. There was an independent association between higher concentrations of serum amyloid A and Z-score, body mass index, apolipoprotein B, and carotid intima-media thickness, indicating the importance of this inflammatory biomarker in identifying the early risk of atherosclerosis.
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Serum amyloid A in children and adolescents: association with overweight and carotid intima-media thickness
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