Abstract
A study was conducted to determine whether the catabolism of an intravenously injected fat emulsion could be correlated with lipoprotein lipase (LPL) mass and activity in postheparin plasma. We observed the relationship between the fractional removal rate (K2) of an intravenously injected fat emulsion (Intralipid®) and LPL mass and activity in postheparin plasma of 20 normolipidemic and 21 hypertriglyceridemic subjects. The K2 level was determined by the intravenous fat emulsion tolerance test. LPL mass was measured by a sandwich enzyme immunoassay system. K2 was significantly correlated with the LPL mass in total group of subjects (r=0.51, p<0.001), as well as in normolipidemic (r=0.72, p<0.001) and hypertriglyceridemic (r=0.43, p<0.05) subgroups. K2 was also significantly correlated with LPL activity in the total group (r=0.40, p<0.05), as well as in the normolipidemic subjects (r=0.55, p<0.05). Kinetics following an intravenous injection of a fat emulsion reflect LPL mass and activity in postheparin plasma.
