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Flow Cytometry Analysis of G0/G1 Diploid Cell Fraction in Ovarian Cancer Tissue

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Moscow University Chemistry Bulletin Aims and scope

Abstract

The proportion of diploid cells in the G0/G1 cell cycle phases was estimated by flow cytometry in 60 samples of stage III serous ovarian cancer tissue. The tumor tissue shows considerable heterogeneity with regard to the content of this tissue fraction, which ranged from 27 to 95% with a median of 73%. Statistically significant differences in the size of this fraction were identified by comparing tumor subgroups sensitive and resistant to first-line platinum-taxane chemotherapy. Predictive significance of the G0/G1 fraction was concluded and quantitative evaluation of this fraction is recommended for clinical use.

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Authors and Affiliations

  1. Blokhin National Medical Research Center of Oncology, Ministry of Healthcare of the Russian Federation, Moscow, 115478, Russia

    T. A. Bogush, I. A. Mamichev, E. A. Bogush & N. O. Vichljantseva

  2. Department of Fundamental Medicine, Moscow State University, Moscow, 119991, Russia

    Iu. P. Borisenko

  3. Sechenov First Medical University, Ministry of Healthcare of the Russian Federation, Moscow, 119991, Russia

    V. Ju. Kirsanov

Authors
  1. T. A. Bogush
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  2. I. A. Mamichev
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  3. Iu. P. Borisenko
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  4. E. A. Bogush
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  5. N. O. Vichljantseva
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  6. V. Ju. Kirsanov
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Correspondence to T. A. Bogush.

Additional information

Original Russian Text © T.A. Bogush, I.A. Mamichev, Iu.P. Borisenko, E.A. Bogush, N.O. Vichljantseva, V.Ju. Kirsanov, 2018, published in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya, 2018, No. 5, pp. 369–373.

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Bogush, T.A., Mamichev, I.A., Borisenko, I.P. et al. Flow Cytometry Analysis of G0/G1 Diploid Cell Fraction in Ovarian Cancer Tissue. Moscow Univ. Chem. Bull. 73, 244–247 (2018). https://doi.org/10.3103/S0027131418050024

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  • DOI: https://doi.org/10.3103/S0027131418050024

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