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Pharmacogenomics of cisplatin-based chemotherapy in ovarian-cancer patients from Yakutia

  • Cancer Proteomics
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Molecular Genetics, Microbiology and Virology Aims and scope Submit manuscript

Abstract

A DNA polymorphism is one of the most important factors determining individual variations in patients’ responses to the same medicinal preparations. This work deals with assessment of associations between polymorphisms of 106 genes involved in key processes of cellular activity (xenobiotic metabolism, DNA repair, the cell cycle, and the regulation of apoptosis) and the outcomes of a cisplatin-based chemotherapy in a cohort of ovarian-cancer patients from Yakutia. The CDKN1B gene polymorphism (rs34330) has been found to be associated with the frequency of complete remissions. The allelic status of this locus was also shown to be significant for progression-free survival. The allelic status at the EPXH1 gene loci (rs2234922 and rs2260863) correlated with impairments in hearing, while the NBN gene polymorphism (rs1063045) was associated with severe emesis.

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Authors and Affiliations

  1. Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 2, Moscow, 123182, Russia

    D. V. Khokhrin, A. V. Khrunin & S. A. Limborska

  2. Yakut Republican Cancer Clinic, ul. Sverdlova 3/2, Yakutsk, Republic of Sakha (Yakutia), 677005, Russia

    F. G. Ivanova

  3. Medical Center, Bank of Russia, Moscow, Russia

    A. A. Moisseev

  4. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, pr. Sevastopol’skii 66, Moscow, 117593, Russia

    V. A. Gorbunova

Authors
  1. D. V. Khokhrin
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  2. A. V. Khrunin
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  3. F. G. Ivanova
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  4. A. A. Moisseev
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  5. V. A. Gorbunova
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  6. S. A. Limborska
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Corresponding author

Correspondence to D. V. Khokhrin.

Additional information

Original Russian Text © D.V. Khokhrin, A.V. Khrunin, F.G. Ivanova, A.A. Moisseev, V.A. Gorbunova, S.A. Limborska, 2013, published in Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya, 2013, No. 4, pp. 6–9.

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Khokhrin, D.V., Khrunin, A.V., Ivanova, F.G. et al. Pharmacogenomics of cisplatin-based chemotherapy in ovarian-cancer patients from Yakutia. Mol. Genet. Microbiol. Virol. 28, 137–140 (2013). https://doi.org/10.3103/S0891416813040034

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  • DOI: https://doi.org/10.3103/S0891416813040034

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