Abstract
The use of natural polymers that form complexes with drug preparations is promising in the development of drugs of new generation. The possibility of complex formation on the interaction of humic acid salts with papaverine, benzohexonium, and B-group vitamins was demonstrated by calorimetric and potentiometric titration. These interactions can occur between the charged groups of a humic acid macroanion and the positively charged centers of drug molecules. The degree of binding of drug preparations by a natural polymer macromolecule can be determined by the charge and the structure of their molecules.
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Original Russian Text © S.L. Khil’ko, R.G. Semenova, 2016, published in Khimiya Tverdogo Topliva, 2016, No. 6, pp. 60–64.
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Khil’ko, S.L., Semenova, R.G. Interaction of humic acid salts with drug preparations. Solid Fuel Chem. 50, 390–394 (2016). https://doi.org/10.3103/S0361521916060057
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DOI: https://doi.org/10.3103/S0361521916060057