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Adsorption Properties of Mesoporous Silica Gel with β-Cyclodextrin as a Pore-Forming Agent Relative to Moxifloxacin

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Moscow University Chemistry Bulletin Aims and scope

Abstract

A method for the synthesis of mesoporous silica gel using β-cyclodextrin as a pore-forming agent is developed. The physical properties and structure of the obtained adsorbent are studied by Fourier-transform IR spectroscopy and the low-temperature adsorption–desorption of nitrogen (BET) method. The material has an average specific surface area of 435 ± 5 m2/g and an average pore size of 5 ± 0.5 nm. This value of the pore size indicates the formation of complex structures from columnar associates of β-cyclodextrin in the synthesis of the material. The adsorption capacity of the obtained material is 0.2 ± 0.05 mg of 2-hydroxypropyl-β-cyclodextrin per milligram of the adsorbent. The dissociation constant of the complexes of moxifloxacin with β-cyclodextrin inside the pores of silica gel is of the order of 5 × 10–3 M. The resulting system of SiO2-β-CD is promising for application in the biomedical chemistry as a carrier of biologically active molecules, particularly as an antibacterial preparation of moxifloxacin.

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Authors and Affiliations

  1. Department of Chemistry, Moscow State University, Moscow, 119991, Russia

    A. A. Skuredina, M. R. Danilov, I. M. Le-Deygen & E. V. Kudryashova

Authors
  1. A. A. Skuredina
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  2. M. R. Danilov
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  3. I. M. Le-Deygen
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  4. E. V. Kudryashova
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Corresponding author

Correspondence to A. A. Skuredina.

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Original Russian Text © A.A. Skuredina, M.R. Danilov, I.M. Le-Deygen, E.V. Kudryashova, 2018, published in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya, 2018, No. 4, pp. 305–312.

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Skuredina, A.A., Danilov, M.R., Le-Deygen, I.M. et al. Adsorption Properties of Mesoporous Silica Gel with β-Cyclodextrin as a Pore-Forming Agent Relative to Moxifloxacin. Moscow Univ. Chem. Bull. 73, 192–198 (2018). https://doi.org/10.3103/S0027131418040107

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  • DOI: https://doi.org/10.3103/S0027131418040107

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