Abstract
The possibility of using glycol chitosan to obtain stabilized liposome containers for doxorubicin delivery is demonstrated. The dissociation constants of the liposome complexes with glycol chitosan (3.4 × 10–4 and 1.10 × 10–5 depending on the aggregation state of the liposomes) are determined. It is shown that the formation of liposome complexes with glycol chitosan has a significant prolongation effect on the release of doxorubicin from the liposomes at pH 7.4.
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Original Russian Text © I.M. Deygen, E.V. Kudryashova, 2016, published in Vestnik Moskovskogo Universiteta. Khimiya, 2016, No. 3, pp. 154–159.
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Deygen, I.M., Kudryashova, E.V. Effect of glycol chitosan on functional and structural properties of anionic liposomes. Moscow Univ. Chem. Bull. 71, 167–171 (2016). https://doi.org/10.3103/S0027131416030044
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DOI: https://doi.org/10.3103/S0027131416030044