Project description DEENESFRITPL An integrated response against COVID-19 As with any pandemic, response and containment measures against COVID-19 must be based on a combination of clinical, epidemiologic and immunological information. The EU-funded CORESMA project is working on an mHealth surveillance system to obtain real-time clinical data and improve risk assessment in countries most likely to be heavily affected by COVID-19. Researchers will also investigate the role of pre-existing cross or partial immunity against COVID-19 in susceptibility. Using comprehensive modelling and artificial intelligence, they will identify predictors for severe outcome, transmission dynamics and intervention effectiveness. Results will not only help tackle the pandemic but also provide a sustainable strategy for the future. Show the project objective Hide the project objective Objective Among the biggest challenges in the COVID-19 outbreak are the lack of triangulation of clinical, epidemiologic and immunological information for evidence- based response strategies. Our overriding ambition is to overcome this deficit through field studies and implementation research in specific populations early enough to already serve in the response to the current outbreak. Four technical work packages (WP) address the four main objectives: To provide real-time clinical data to improve risk assessment and response, deploying an established mHealth Surveillance Outbreak Response Management and Analysis System (SORMAS) in Nepal, Ivory Coast, Ghana and Nigeria; countries likely to be affected more intensively than the EU.(WP I) To implement differential serolomics (multiplex serology) for population serum samples from Germany and Nepal for investigating pre-existing cross or partial immunity against COVID-19 and impact on susceptibility.(WP II)To apply comprehensive modeling, sampling and artificial intelligence on data from the first two work packages in order to assess predictors for severe outcome, transmission dynamics and intervention effectiveness.(WP III)To measure and improve quality of epidemic containment measures through implementation research in countries particularly vulnerable to the COVID-19 epidemic, in order to tailor effective and efficient control measures to health systems realities in Nepal and Ivory Coast, and to reduce the intensity of importation into the EU. (WP IV)We combine a) an accelerated ad-hoc outbreak response to address the urgency and b) a sustainable strategy to serve beyond the current public health threat from COVID-19. Software maturity, established networks, pre-approval investments and interdisciplinary expertise among partners - including first hand from China - shall generate first findings within weeks, such as validated criteria for high-risk groups, effectiveness of contact tracing, set-up serolomics platform. Fields of science natural sciencescomputer and information sciencesartificial intelligencemedical and health scienceshealth scienceshealth care serviceseHealthnatural sciencescomputer and information sciencessoftwaremedical and health scienceshealth sciencespublic healthepidemiologyepidemics preventionmedical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses Keywords eHealth immuno diagnostic seroprevalence artificial intelligence modeling respondent driven sampling implementation research cohort study response management SORMAS Nepal China Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.3. - Treating and managing disease Topic(s) SC1-PHE-CORONAVIRUS-2020 - Advancing knowledge for the clinical and public health response to the 2019-nCoV epidemic Call for proposal H2020-SC1-PHE-CORONAVIRUS-2020 See other projects for this call Funding Scheme RIA - Research and Innovation action Coordinator HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH Net EU contribution € 1 108 205,00 Address INHOFFENSTRASSE 7 38124 Braunschweig Germany See on map Region Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 108 205,00 Participants (6) Sort alphabetically Sort by Net EU contribution Expand all Collapse all RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU Netherlands Net EU contribution € 274 533,75 Address Antonie Van Leeuwenhoeklaan 9 3721 MA Bilthoven See on map Region West-Nederland Utrecht Utrecht Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 274 533,75 SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT Switzerland Net EU contribution € 313 055,00 Address KREUZSTRASSE 2 4123 Allschwil See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Landschaft Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 313 055,00 NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN Germany Net EU contribution € 362 001,25 Address MARKWIESENSTRASSE 55 72770 Reutlingen See on map Region Baden-Württemberg Tübingen Reutlingen Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 362 001,25 BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY China Net EU contribution € 0,00 Address BEI SAN HUAN DONG LU 15 CHAO YANG QU 100029 BEIJING See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data MINISTRY OF HEALTH AND POPULATION Nepal Net EU contribution € 515 900,00 Address RAMSHAHPATH Kathmandu See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 515 900,00 National Institute of Public Hygiene Côte d’Ivoire Net EU contribution € 185 500,00 Address Rue du port, Treichville, Abidjan, BP V14 Abidjan See on map Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 185 500,00