In this research, natural aggregates were replaced with desulfurization slag aggregates for asphalt concrete, and the criteria of heavy traffic (two sides compacted with 75 blows) in AI MS-2 were taken as reference, the control samples used natural aggregates. For researching the applying methods of AC paving engineering, coarse, fine and all aggregates in asphalt concrete be replaced with desulfurization slag in this research, and the Marshall mix design method and basic properties testing results are adopted for analyzing the materials properties and estimating economic benefits.The result shows the recommended asphalt contents of various replacing methods of asphalt concrete with desulfurization slag are higher than the control sample. Some desulfurization slag particles broke when molding the AC specimens that resulted in degrading of original aggregate gradation. For the engineering properties, the unit weights and stabilities of fine aggregate and all aggregates be replaced are lower than the control samples but their flow values and VMA are higher than the control ones. For the samples whose coarse aggregate be replaced, the unit weights and stabilities are higher than the control samples but their flow values and VMA are lower than the control ones. For economic benefits estimation, transporting and AC plant mixing expenses are not included but just consider the unit prices of materials, it recommends that asphalt content should be controlled lower than 7.0%.