This report describes the experience of nursing care to a female patient who suffered from dementia and sleep disturbance due to deterioration of self-care ability, poor memory, repetitive questioning and negativities. In general, a foreign caregiver takes care of her daily life, the family members have limited knowledge of the disease and the relationship with the case was tense. This leads to great pressure on both the family members and caregivers. The clinical care issues are complicated and the family care is a hefty loading. During the period of nursing care, from December 24, 2019 to January 17, 2020, through on-the-spot care, observation, interviews, laboratory test results, review of medical records, and telephone interviews, data are collected, and holistic nursing assessments are carried out according to five aspects. The main nursing issues identified include "potentially dangerous suicide", "sleep pattern disturbance", and "caregiver role tension". In order to help the case to improve mood and sleep quality, 3R communication skills, arranges regular daily schedule and exposure to natural light were applied. Moreover, guide family members and her caregivers about knowledge and skills needed for dementia care, and made a referral to a dementia care center for follow-up counseling and social support. At the same time, also provide relevant information in the hospital to increase social support, reduce conflicts and care load with the case, so that the dementia patient can receive better quality care, and the family can continue to operate smoothly. Apart from being familiar with the care of the acute phase of the disease, it is recommended that the clinical nurses also need to know how to assist in referrals and provide relevant care resources to caregivers, so that they can double the result with half the effort in the caring mission. It is hoped that with this experience in dementia care, it can provide nursing staff as a caring reference.