CHARACTERISTICS OF THE CONTENT OF ZINC, COPPER AND SELENIUM IN BLOOD SERUM IN PATIENTS WITH CHRONIC HEPATITIS C WITH DIFFERENT BODY MASS INDEX

Sitkar A. D.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Introduction. More than 71 million people, or about 1% of the world’s population, are infected with the hepatitis C virus. The main clinical form of this infection is chronic hepatitis C, which develops in an average of 70% of patients. Metabolic disorders caused by the chronic hepatitis C infection include changes in the metabolism of trace elements, in particular zinc (Zn), copper (Cu) and selenium (Se), since their basic metabolism takes place in the liver. Violation of the homeostasis of these trace elements can increase hepatitis C virus replication and liver fibrosis and reduce the effectiveness of antiviral therapy, which determines the relevance of researching the levels of these trace elements in such patients. The aim. Evaluate the content of trace elements Zn, Cu and Se in the blood serum of patients with chronic hepatitis C depending on sex, age and body mass index. Materials and methods. 62 patients with a verified diagnosis of chronic hepatitis C were under observation, in whom the level of Zn, Cu and Se in blood serum was determined. The control group consisted of 30 healthy people. Results. There was no statistically significant difference between the studied groups depending on age (p=0,16), sex (p=0,747) and body mass index (p=0,319), i.e. they were homogeneous. The proportion of patients with chronic hepatitis C in whom the serum Zn level was below normal was 19,4% (12/62). The level of Zn was statistically significantly lower in patients with chronic hepatitis C compared to healthy people (0,649 (0,569; 0,739) mg/l vs. 0,720 (0,645; 0,835) mg/l; p=0,022). The detected levels of Cu and Se in the examined persons did not exceed the normal limits, and no statistically significant difference was established between the groups regarding the level of Cu (р=0,069) and Se (р=0,149). In patients with chronic hepatitis C, the average levels of trace elements in both men and women were almost at the same level and did not differ statistically significantly (р>0,05). The levels of the studied trace elements did not depend on the body mass index and did not correlate with age in both groups (p>0,05). A weak degree of negative correlation (ρ=–0,271, p=0,033) was found between the levels of Zn and Cu in patients with chronic hepatitis C. The average value of the Cu/Zn ratio in the group of patients was statistically significantly higher compared to the healthy people (p=0,002). Conclusions. The obtained data indicate a probable effect of chronic hepatitis C infection on the level of Zn in blood serum, which creates prerequisites for further research.

chronic hepatitis C,trace elements,zinc.

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«Bulletin of problems biology and medicine» Issue 3 (166), 2022 year, 245-249 pages, index UDK 616.36-002.2:577.118

10.29254/2077-4214-2022-3-166-245-249