FEATURES OF CHRONIC RECURRENT APHTHOSIS STOMATITIS AFTER COVID-19

Sukmanskaya G. D., Kryzhanovskaya A. V.

MICROBIOLOGY

Scentific article

The development of inflammatory processes that occur as a result of disruption of the normal state of the mucosal epithelium of the oral mucosa, contributes to infectious, tumor, autoimmune and other pathologies, including CoViD-19, chronic recurrent aphthous stomatitis. The purpose of the investigation was to study the effect of CoViD-19 infection on the features of chronic recurrent aphthous stomatitis; research of the effectiveness of the therapeutic composition based on the antiseptic decamethoxine. Observations were performed with 125 patients with erosive elements on the oral mucosa. The study was performed using clinical, serological, bacteriological methods. The results of a comparative analysis of the frequency of seeking medical help from patients with chronic recurrent aphthous stomatitis before and during the CoViD-19 pandemic indicate a gradual increase in the number of patients with this disease. Features of erosive elements, their localization in patients of the early period after CoViD19 and in those who did not have a history of coronavirus infection. The results of microbiological studies of aphthae of patients showed a high population density of erosive elements by various bacterial or bacterial-fungal associations of microorganisms, which included at least three morphologically distinct species of bacteria. The dominant microorganisms in the associations in 100% of the surveyed were α- and β-hemolytic streptococci, regardless of the observation group. The positive experience of local use of the original drug decamethoxine-containing composition in the treatment of chronic recurrent aphthosis stomatitis in post-CoViD patients confirms the high therapeutic efficacy of the drug in cases of local lesions with complex viral and bacterial etiopathogenesis.

chronic recurrent aphthous stomatitis, coronavirus infection, decamethoxine, treatment.

1. Spetsializovanyy medychnyy portal. Slyzova obolonka porozhnyny rota yak chastyna limfatychnoyi systemy: faktory lokalʹnoho imunitetu. Pediatriya [Internet]. 2008 Hrud [tsytovano 2015 Ber 27];24(1). Dostupno: https://health-ua.com/article/15971-slizova-obolonka-porozhninirota-yak-chastina-lmfatichno-sistemi-faktori-lo. [in Ukrainian].
2. Savychuk NO. Kolonizatsiyna rezystentnistʹ porozhnyny rota. Ukrayinsʹkyy medychnyy chasopys [Internet]. 2012 Lyp Serp;4(90):57-63. Dostupno: https://www.umj.com.ua/article/39590/kolonizacijna-rezistentnist-porozhnini-rota. [in Ukrainian].
3. Moutsopoulos NM, Lionakis MS, Hajishengallis G. Inborn errors in immunity: Unique natural models to dissect oral immunity. J. Dent. Res. 2015 Jun;94(6):753-758.
4. Baker JL, Edlund A. Exploiting the oral microbiome to prevent tooth decay: Has evolution already provided the best tools? Front. Microbiol. 2019 Jan 11;9:3323.
5.  Yankovsʹkyy DS, Shyrobokov VP, Dyment HS. Mikrobiom u fiziolohiyi lyudyny. Infektsiyni khvoroby. 2018 Zhovt 26;93(3):5-17. [in Ukrainian].
6. Takeshita T, Kageyama S, Furuta М, Tsuboi H, Takeuchi K, Shibata Y, et. al. Bacterial diversity in saliva and oral health-related conditions. The Hisayama Study. Sci. Rep. 2016 Feb 16;6:22164.
7. Maoyang L, Songyu X, Zhao W. Oral microbiota: A new view of body health. Food Science and Human Wellness. 2019 Jan 3;8:8-15.
8. Dyachenko VF, Voronkina IA, Maryushchenko AM, Serdechna ES, Biryukova SV, Kkheder SS. Deyaki aspekty vyvchennya stanu mikroflory rotovoyi porozhnyny. Annals of Mechnikov Institute. 2020 Dec 26;4:41-44. [in Ukrainian].
9. Melʹnyk AL, Dovha IM, Khrystyan HYE, Radchenko OO, Povolokina IV, Kazmirchuk VV. Intehralʹna kharakterystyka infektsiyno-zapalʹnykh zakhvoryuvanʹ porozhnyny rota. Klinichna ta eksperymentalʹna patolohiya. 2015 Serp 13;14(1):215-220. [in Ukrainian].
10. Lobanʹ HA, Faustova MO, Ananʹyeva MM, Basarab YaO. Vlastyvosti mikroorhanizmiv, shcho formuyutʹ bioplivku porozhnyny rota. Zaporizhsʹkyy medychnyy zhurnal. 2019 Trav 31;21(3):391-396. [in Ukrainian].
11. Kopcha VS. Osoblyvosti imunozalezhnykh proyaviv pry COVID-19. Infektsiyni khvoroby. 2021 Cher 30;104(2):4-16. [in Ukrainian].
12. Galván Casas C, Català A, Carretero Hernández G, Rodríguez-Jiménez P, Fernández-Nieto D, Rodríguez-Villa Lario A, et al. Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases. Br J Dermatol. 2020 Jul;183(1):71-77.
13. Shyrobokov VP, Ponyatovsʹkyy VA. Koronavirusni infektsiyi u lyudyny. Infektsiyni khvoroby. 2020 Serp 13;100(2):31-40. [in Ukrainian].
14. Malyy VP, Asoyan IM, Say IV, Andrusovych IV. Patohenez koronavirusnoyi infektsiy COVID-19. Infektsiyni khvoroby. 2020 Hrud 16;101(3):73-82. [in Ukrainian].
15. Herrera D, Serrano J, Roldán S, Sanz M. Is the oral cavity relevant in SARS-CoV-2 pandemic? Clin Oral Investig. 2020 Aug;24(8):2925- 2930.
16. Tereshina TP, Kot MI. Vliyaniye COVID-19 na funktsional’nuyu aktivnost’ slyunnykh zhelez (Predvaritel’noye issledovaniye). Vísnik stomatologíí̈. 2021 Trav 26;113(4):35-38. [in Ukrainian].
17. Hryhor’yeva SM, Yehorov DP. Doslidzhennya mikroflory respiratornoho traktu ditey riznoho viku, khvorykh na COVID-19. Aktualʹnaya ynfektolohyya [Internet]. 2020;8(5):1. Dostupno: http://www.mif-ua.com/ archive/article/49855. [in Ukrainian].
18. Bordyy T. Retsydyvyruyushchyy aftoznyy stomatyt. Z turbotoyu pro dytytnu [Internet]. 2014 [tsytovano 2014 Trav 1];48(3). Dostupno: https://extempore.info/component/content/article/9-joornal/458-eroziya-i-ektopiya-rasstavim-vse-po-mestam-vzglyad-onkoginekologanatsional-nogo-instituta-raka-197.html?Itemid=357. [in Ukrainian].
19. Zelenkova KO. Etiolohiya ta patohenez khronichnoho retsydyvuyuchoho aftoznoho stomatytu. Visnyk Ukrayinsʹkoyi medychnoyi stomatolohichnoyi akademiyi. 2007;7(3):189-192. [in Ukrainian].
20. Kovach I, Dychko S, Bunyatyan KH, Kravchenko L, Khotymsʹka YU. Porushennya metabolizmu slyzovoyi obolonky porozhnyny rota pry khronichnomu retsydyvuyuchomu aftoznomu stomatyti. Norwegian Journal of development the Internetionfl Sciens. 2020;1(47):9-12. [in Ukrainian].
21. Kovach IV, Kravchenko LI. Dynamika pokaznykiv nespetsyfichnoyi rezystentnosti porozhnyny rota u ditey pry likuvanni khronichnoho retsydyvuyuchoho aftoznoho stomatytytu. Sovremennaya stomatolohyya. 2015 Lyst 12;79(5):31-35. [in Ukrainian].
22. Fomina NS, Sukmansʹka HD, Kordon YUV, Trofimenko YUYU. Udoskonalenyy metod likuvannya aftoznykh urazhenʹ slyzovoyi obolonky porozhnyny rota. Visnyk Vinnytsʹkoho natsionalʹnoho medychnoho universytetu. 2020 Lut 28;24(1);143-146. [in Ukrainian].
23. Gupta A, Madhavan MV, Sehgal K, Nair N, Mahajan S, Sehrawat TS, et al. Extrapulmonary manifestations of COVID-19. Nat. Med. 2020 Jul 10;26:1017-1032.
24. Pavli A, Theodoridou M, Maltezou HC. Post-COVID syndrome: Incidence, clinical spectrum, and challenges for primary healthcare professionals. Arch. Med. Res. 2021 Aug;52(6):575-581.
25. Hasichaolu, Zhang Xinri, Li X, Li X, Li D. Circulating cytokines and lymphocyte subsets in patients who have recovered from COVID-19. Biomed Res Int. 2020 Nov 26;2020:7570981.
26. Volosovetsʹ TM. Otsinka efektyvnosti diahnostyky ta likuvalʹnoyi taktyky khronichnoho retsydyvuyuchoho aftoznoho stomatytu. Visnyk stomatolohiyi. 2021 Trav 26;2020;110(1):22-26. [in Ukrainian].
27. Yurochko F, Kopansʹka D. Suchasna diahnostyka ta kompleksna terapiya retsydyvuyuchoho aftoznoho stomatytu. Zdorov’ya Ukrayiny. [Internet]. 2020 [tsytovano 2020 Hrud 30]. Dostupno: https://health-ua.com/article/62874-suchasna-dagnostika-takompleksna-terapyaretcidivuyuchogo-aftoznogo-stomati. [in Ukrainian].
28. Hrydina TL. Protyvirusni vlastyvosti ofitsinalʹnykh preparativ dekametoksynu, etoniyu ta unitiolu po vidnoshennyu do virusiv hrypu ta prostoho herpesu [avtoref.]. Kyiv: Instytut mikrobiolohiyi i virusolohiyi im.D.K.Zabolotnoho NAN Ukrayiny; 2008. 14 s. [in Ukrainian].
29. Humenyuk MI, Humenyuk HL, Opimakh SH. Efektyvnistʹ dekametoksynu proty skladnykh virusiv, nezalezhno vid yikh antyhennoyi budovy: perspektyvy vykorystannya pry suchasnykh virusnykh zakhvoryuvannyakh dykhalʹnykh shlyakhiv. Aktualʹnaya ynfektolohyya [Internet]. 2020;8(1). Dostupno: http://www.mif-ua.com/archive/article/48771. [in Ukrainian].
30. Kovalʹchuk VP, Fomina NS, Fomin OO, Sukmansʹka HD, Khimich OS, vynakhidnyky; Kovalʹchuk VP, Fomina NS, Fomin OO, Sukmansʹka HD, Khimich OS, patentovlasnyky. Protymikrobna likarsʹka kompozytsiya dlya likuvannya infikovanykh ran z upovilʹnenoyu reparatsiyeyu. Patent Ukrayiny na korysnu modelʹ №143113. 2020 Lyp 10. [in Ukrainian].

«Bulletin of problems biology and medicine» Issue 1 (163), 2022 year, 208-213 pages, index UDK 615.28:616.31-001-08:578.834.1

10.29254/2077-4214-2022-1-163-208-213