year 18, Issue 70 (5-2019)                   J. Med. Plants 2019, 18(70): 188-196 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Pazoki A, Arshadi S. Effect of 8 Week Consumption Flax Seed Supplementation with Endurance Training on BDNF and IGF-1 in Obese Women. J. Med. Plants 2019; 18 (70) :188-196
URL: http://jmp.ir/article-1-2574-en.html
1- Department of Sport Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran
2- Department of Sport Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran , arshadi.sajjad@yahoo.com
Abstract:   (4050 Views)
Background: Obesity and weight gain can cause health risks for people with metabolic disorders. Endurance activities and some herbal supplements can reduce the risks of metabolic syndrome by affecting hormonal indices and body weight.
Objective: The present study examined the effect of 8 weeks of endurance training and supplementation of flax seed on BDNF and IGF-1 in obese women.
Methods: 48 female obese 30-40 years old were selected and randomly divided into four groups: control (Con), endurance training (ET), supplemented flax seed (Sup) and combination (endurance training + Supplementation of flax seed (ET + Sup)). Endurance training included 8 weeks of increasing activity with an intensity of 30% to 70% of VO2 max. Flax seed supplements were consumed in powdery form at a dose of 6 g per day. T-test and one way ANOVA were used for statistical analysis. The turkey's post hoc test was used at the level of 0.05.
Results: Body weight showed a significant change in exercise, exercise + supplementation groups. The results of significant increase in BDNF showed a significant decrease in IGF-1 in both ET and ET + Sup groups compared to Con and Sup (P≤0.05). But the difference between the ET and ET + Sup groups was not significant.
Conclusion: The findings of this study showed that aerobic training with flaxseed can be more effective in reducing body weight and improving metabolic parameters in obese women. These effects were associated with an increase in BDNF and a decrease in IGF-1 levels.
Full-Text [PDF 796 kb]   (1172 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2018/06/9 | Accepted: 2018/11/21 | Published: 2019/05/26

References
1. Damirchi A, Babaei P and Azali Alamdari K. Effects of aerobic training on metabolic risk factors and BDNF in midlife males. Journal of Sport in Biomotor Sciences 2012; 6 (2): 51-61. [In Persian]
2. Bahadoran Z, Mirmiran P, Tohidi1 M, Mehran M and Azizi F. Evaluation of the Effect of two doses of broccoli sprouts powder on lipid peroxidation and oxidant/antioxidant balance in type 2 diabetic patients. Research in Medicine 2012; 35 (4): 215-220. [In Persian]
3. Changizi Ashtiyani S, Zarei A, Taheri S and Ramazani M. Effect of alcoholic extract of Portulaca Oleracea on serum level of thyroid hormones in hypercholestrolemic Rats. J. Gorgan Univ. Med. Sci. 2015; 17 (2): 52-58. [DOI:10.17795/zjrms-4025]
4. Bahrebar M, Bohaoddini A, Bahrebar A, Taherianfard M, Razavi Motlagh M and Bahrebar A. Study of the Effects of Vitex agnus-castus Leaf Extract on the Serum Concentration of Choleste rol and Triglyceride in Male Rats. Food Technology & Nutrition 2010; 7 (4): 20-32. [In Persian]
5. Jalali F, Hajian K, Baradaran M and Moghaddamnia AA. Effect of Linseed (Seed of Flax) on blood lipid levels. Pajoohandeh J. 2008; 13 (2): 107-13. [In Persian].
6. Machado A.M, de Paula H, Cardoso L.D and Costa N.M.B. Effects of brown and golden flaxseed on the lipid profile, glycemia, inflammatory biomarkers, blood pressure and body composition in overweight adolescents. Nutrition 2015; 31: 90 - 6. [DOI:10.1016/j.nut.2014.05.002]
7. Shirazi A, Golab F, Sanadgol N, Barati M, Mohammad Salehi R, Vahabzadeh G and et al. Evaluation of the neurotrophic factors in animal model of myelin destruction induced by cuprizone in c57bl/6 mice. Shefaye Khatam 2016; 4 (2): 47-54. [In Persian] [DOI:10.18869/acadpub.shefa.4.2.47]
8. Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR and et al. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat. Neurosci. 2003; 6: 736-42. [DOI:10.1038/nn1073]
9. Golden E, Emiliano A, Maudsley S, Windham BG, Carlson OD, Egan JM and et al. Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore LongitudinalStudy of Aging. PloS One 2010; 5: e e10099. [DOI:10.1371/journal.pone.0010099]
10. DeLellis K, Rinaldi S, Kaaks RJ, Kolonel LN, Henderson B and Le Marchand L. Dietary and lifestyle correlates of plasma insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3): the multiethnic cohort. Cancer Epidemiol. Biomarkers Prev. 2004; 13: 1444-51
11. Jones JI and Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr. Rev. 1995; 16 (1): 3-34. [DOI:10.1210/edrv-16-1-3]
12. Manetta J, Brun JF, Maimoun L, Callis A, Préfaut C and Mercier J. Effect of training on the GH/IGF-I axis during exercise in middle-aged men: Relationship to glucose homeostasis. Am. J. Physiol. Endocrinol. Metab. 2002; 283 (5): 929-36. [DOI:10.1152/ajpendo.00539.2001]
13. Pareja-Galeano H, Brioche T, Sanchis-Gomar F, Montal A, Jovaní C, Martínez-Costa C and et al. Impact of exercise training on neuroplasticity related growth factors in adolescents. J. Musculoskelet. Neuronal Interact. 2013; 13 (3): 368-71.
14. Grundy SM, Brewer HB, Cleeman JI, Smith SC and Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related todefinition. Arterioscler. Thromb Vasc. Biol. 2004; 24: e13-8. [DOI:10.1161/01.ATV.0000111245.75752.C6]
15. Raffaelli F, Nanetti L, D'Angelo M, Montecchiani G, Alidori A and Montesi L. Interactions between lipoproteins and platelet membranes in obesity. Obesity 2009; 17: 1375-80. [DOI:10.1038/oby.2008.654]
16. Kong AP, Choi KC, Wong GW, Ko GT, Ho CS, Chan MH and et al. Serum concentrations of insulin like growth factor-I, insulin-like growth factor binding protein-3 and cardiovascular risk factors in adolescents. Ann. Clin. Biochem. 2011; 48 (Pt 3): 263- 9. [DOI:10.1258/acb.2011.010267]
17. Mozayan Kharazi E and Matin Hamoei H.. Effect of 8 weeks of endurance, resistance and parallel training on GH, IGF-1 and IL-15 in young athletes. Central Teh branch Uni. 2014; 21: 46-55 [In Persian]
18. Salehi O R and Hoseini A. The Effects of Endurance Trainings on Serum BDNF and Insulin Levels in Streptozotocin-Induced Diabetic Rats. Shefaye Khatam. 2017; 5 (2): 52-61. [In Persian] [DOI:10.18869/acadpub.shefa.5.2.52]
19. Rafiei S, Bazyar Y and Edalatmanesh MA. Effect of gallic acid and endurance exercise training on bdnf in a model of hippocampal degeneration. Shefaye Khatam. 2016; 4 (1): 1-6. [DOI:10.18869/acadpub.shefa.4.1.1]
20. Eslami R, Sorkhkamanzadeh G, Kazemi A, Gharakhanlou R and Banaifar A. Effect of 6-week endurance training on bdnf expression in motor root of spinal cord in rats with diabetic neuropathy. Mazandaran Med. Sci. Univ. J. 2015; 25 (124): 94-110.
21. Salehi I, Farajnia S, Mohammadi M, Sabouri Ghannad S. The pattern of brain-derived neurotrophic factor gene expression in the hippocampus of diabetic rats. Iranian J. Basic. Med. Sci. 2010; 13 (3): 146-53.
22. Muller M, Tang MX, Schupf N, Manly JJ, Mayeux R and Luchsinger JA. Metabolic syndrome and dementia risk in a multiethnic elderly cohort. Dementi. Geriatr. Cogn. Disord. 2007; 24: 185-92. [DOI:10.1159/000105927]
23. Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras SA, Yannakoulia M and et al. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism 2005; 54 (11): 1472-9. 36. [DOI:10.1016/j.metabol.2005.05.013]
24. Schiffer T, Schulte S, Hollmann W, Bloch W and Struder HK. Effects of strength and endurance training on brain-derived neurotrophic factor and insulin-like growth factor 1 in humans. Metab. Res. Rev. 2009; 41 (3): 250-4. [DOI:10.1055/s-0028-1093322]
25. Corripio R, Gonzalez-Clemente JM, Jacobo PS, Silvia N, Lluis G, Joan V and et al. Plasma brain-derived neurotrophic factor in prepubertal obese children: results from a 2-year lifestyle intervention programme. Clin. Endocrinol. (Oxf) 2012; 77 (5): 715-20. [DOI:10.1111/j.1365-2265.2012.04431.x]
26. Meeusen R. Exercise, nutrition and the brain. Sports Med. 2014; 44 (Suppl 1): S47-56. [DOI:10.1007/s40279-014-0150-5]
27. Huang T, Larsen KT, Ried-Larsen M, Moller NC and Andersen LB. The effects of physical activity and exercise on brain-derived neurotrophic factor in healthy humans: A review. Scand J. Med. Sci. Sports. 2014; 24 (1): 1-10. [DOI:10.1111/sms.12069]
28. Kim YG and Kim HJ. Exercise-induced increase of BDNF decreased TG and glucose in obese Adolescents. J. Exerc. Nutr. Biochem. 2013; 17 (3): 87-93. [DOI:10.5717/jenb.2013.17.3.87]
29. Lee SS, Yoo JH, Kang S, Woo JH, Shin KO, Kim KB, Cho SY, Roh HT and Kim YI. The Effects of 12 Weeks Regular Aerobic Exercise on Brain-derived Neurotrophic Factor and Inflammatory Factors in Juvenile Obesity and Type 2 Diabetes Mellitus. J. Phys. The.r Sci. 2014; 26 (8): 1199-204. [DOI:10.1589/jpts.26.1199]
30. Fallah Mohammadi Z and Nazari H. The effect of 4 weeks plyometric training on serum concentration of brain derived neurotrophic factor of active mal. Sport Physiol. 2013; 20 (5): 29-38.
31. Vosadi E, Ravasi AA, Choobine S, Barzegar H and Borjianfard M. Effect of endurance training and omega-3 supplementation in brain-derived neurotrophic factor (BDNF) in male adult rat hippocampus. R.J.M.S. 2013; 20 (111): 50-7.
32. Hosseini A, Parno A, Karimi A and Hosseini B. The effect of 4 weeks resistance training on plasma levels of brain derived neurotrophic factor of rats. Biol. Sci. Appl. Res. Sport. 2015; 6 (3): 42-51.
33. Babaei P, Damirchi A and Azali Alamdari K. Effects of endurance training and detraining on serum bdnf and memory performance in middle aged males with metabolic syndrome. Iranian J. Endocrinology Met. 2013; 15 (2): 132-42. [In Persian]
34. Ben Ounis O, Elloumi M, Zouhal H, Makni E, Denguezli M, Amri M and et al. Effect of individualized exercise training combined with diet restriction on inflammatory markers and IGF- 1/IGFBP-3 in obese children. Ann. Nutr. Metab. 2010; 56 (4): 260-6. [DOI:10.1159/000275888]
35. Habibian M, Khosravi H and Farzanegi P. The Effects of 8 Weeks of Vitamin C Intake and Regular Aerobic Exercise on Serum Brain-Derived Neurotrophic Factor and Insulin-like Growth Factor-1 Levels in Obese Girls. Iranian Journal of Nutrition Sciences & Food Technol. 2016; 11 (3): 21-30.

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb